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A kind of preparation method of compound triamcinolone acetonide acetate solution

A triamcinolone acetonide acetate solution technology, applied in the field of medicine, can solve problems affecting the effectiveness of the solution, skin irritation, and aggravate the pressure of environmental governance, and achieve the effects of no pollution in the preparation process, simple preparation process, and low production cost

Active Publication Date: 2016-05-11
广东恒诚制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this technique can solve the problem of poor stability of compound triamcinolone acetonide solution, it still has the following disadvantages: (1) the use of inorganic bases and / or antioxidants will undoubtedly increase production costs, although the relative amount is very small, but for large-scale In terms of industrial production, it should not be underestimated; (2) The active ingredients in the compound triamcinolone acetonide solution itself are slightly irritating to the skin, and the use of antioxidants such as vitamin C will aggravate the irritation, thereby affecting the safety of the solution (3) The use of inorganic bases will reduce the activity of salicylic acid and affect the effectiveness of the solution; (4) The prepared inorganic bases and / or antioxidants used in the process, such as NaOH, Na 2 CO 3 , NaHCO 3 , vitamin C, and glycine are all obtained from industrial production. The production process of these substances will more or less produce pollutants, which will increase the pressure on environmental governance. This cannot be ignored when the environmental pollution problem is so severe today.

Method used

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  • A kind of preparation method of compound triamcinolone acetonide acetate solution
  • A kind of preparation method of compound triamcinolone acetonide acetate solution
  • A kind of preparation method of compound triamcinolone acetonide acetate solution

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] a. Dissolve 0.5g of sodium chloride in 10mL of water, and the resulting solution is used for later use;

[0030] b. adding the aqueous sodium chloride solution obtained in step a to 50L propylene glycol, and stirring evenly;

[0031] c. 100g of triamcinolone acetonide acetate is added to the propylene glycol solution obtained in step b, and stirred evenly;

[0032] d. Add 2000g of salicylic acid to 40L of ethanol, and the resulting solution is ready for use;

[0033] e. Mix the triamcinolone acetonide acetate solution obtained in step c with the salicylic acid solution obtained in step d, add 2 L of laurocapram,

[0034] Stir well, add ethanol to 100L, and filter.

Embodiment 2

[0036] a. Dissolve 1g of sodium chloride in 10mL of water, and the resulting solution is used for later use;

[0037] b. adding the aqueous sodium chloride solution obtained in step a to 50L propylene glycol, and stirring evenly;

[0038] c. 100g of triamcinolone acetonide acetate is added to the propylene glycol solution obtained in step b, and stirred evenly;

[0039] d. Add 2000g of salicylic acid to 40L of ethanol, and the resulting solution is ready for use;

[0040] e. Mix the triamcinolone acetonide acetate solution obtained in step c with the salicylic acid solution obtained in step d, add 2 L of laurocapram, stir evenly, add ethanol to dilute to 100 L, and filter.

Embodiment 3

[0042] a. Dissolve 1g of sodium chloride in 5mL of water, and the resulting solution is used for later use;

[0043] b. adding the aqueous sodium chloride solution obtained in step a to 50L propylene glycol, and stirring evenly;

[0044] c. 100g of triamcinolone acetonide acetate is added to the propylene glycol solution obtained in step b, and stirred evenly;

[0045] d. Add 2000g of salicylic acid to 40L of ethanol, and the resulting solution is ready for use;

[0046] e. Mix the triamcinolone acetonide acetate solution obtained in step c with the salicylic acid solution obtained in step d, add 2 L of laurocapram, stir evenly, add ethanol to dilute to 100 L, and filter.

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Abstract

The invention discloses a compound triamcinolone acetonide acetate solution preparation method. According to the method, a solution product with excellent stability is obtained by adding appropriate amount of a sodium chloride aqueous solution; in addition, with adoption of the method, the production cost is low, the safety and effectiveness of the product are not affected, the environmental pollution pressure is not worsened, and industrial production and application are suitable.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a preparation method of an external solution, in particular to a preparation method of a compound triamcinolone acetonide acetate solution. Background technique [0002] Compound triamcinolone acetonide acetate solution is a preparation for topical skin application. Its active ingredients are triamcinolone acetonide acetate and salicylic acid. It is mainly used to treat skin allergies, eczema, neurodermatitis, etc. At present, the excipients used in this preparation on the market are laurocapram, propylene glycol and ethanol, but the obtained preparation is unstable, and the content of triamcinolone acetonide acetate often decreases significantly during the storage process, which does not meet the requirements of pharmaceutical standards. [0003] In order to solve the unstable problem of compound triamcinolone acetonide solution, Chinese patent CN101190228 discloses a production p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/60A61K47/02A61K9/08A61P17/00A61P37/08A61P25/00A61K31/58
Inventor 陈越汤小燕张志涛符正南陈雨邓枚
Owner 广东恒诚制药股份有限公司
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