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Heart beneficial keton dispersion tablet and its preparation method

A technology for dispersible tablets and Yixinone, which is applied in the field of pharmaceutical compositions containing Yixinone, can solve the problems of affecting the full absorption and bioavailability of the drug, inconvenient packaging, transportation and storage, and slow disintegration and dissolution speed. , to meet the needs of clinical medication, the drug dissolution rate is fast, the disintegration rate is fast

Inactive Publication Date: 2008-07-16
INST OF PHARMACY SHANDONG PROV ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Disintegration and dissolution are slow, affecting the full absorption and bioavailability of the drug
Although liquid preparations absorb quickly, they are inconvenient to use, have poor stability, and are inconvenient to package, transport, and store

Method used

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  • Heart beneficial keton dispersion tablet and its preparation method
  • Heart beneficial keton dispersion tablet and its preparation method
  • Heart beneficial keton dispersion tablet and its preparation method

Examples

Experimental program
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Embodiment Construction

[0042] The present invention will be further described below in the form of embodiments, and the implementation details of the present invention will be given, but it is not intended to limit the protection scope of the present invention.

[0043] First micronize Yixindone to less than 300 mesh, and pass lactose, microcrystalline cellulose, sodium carboxymethyl starch, and magnesium stearate through a 100-mesh sieve;

[0044] Weigh 3.1 g of polyvinylpyrrolidone and 1.4 g of sodium lauryl sulfate and dissolve them in 70% ethanol to prepare a mixed solution for later use. It contains 5% polyvinylpyrrolidone and 1% sodium lauryl sulfate.

[0045] Weigh 32.0 grams of micronized Yixinone, first mix it with 3.0 grams of sodium carboxymethyl starch in an equal amount, then add 31 grams of microcrystalline cellulose and mix thoroughly, then add 129 grams of lactose to mix, sieve, Add the above mixed solution to make a soft material. Granulate with a 30-mesh sieve, dry at 40°C, and t...

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Abstract

A dispersing tablet of Yixintong is prepared from the micropowdered Yixintong, lactose, microcrystalline cellulose, polyvinyl pyrrolidone, sodium laurylsulfate and carboxymethyl starch sodium through mixing, pulverizing, adding magnesium stearate and residual carboxymethyl starch sodium, stirring and die pressing.

Description

Technical field: [0001] The invention relates to a pharmaceutical composition containing Yixindone, and relates to an improved technology for oral preparations of Yixindone. Background technique: [0002] The following definitions apply throughout the specification and claims: [0003] Yixinketone: It is the general name of the total flavonoids of hawthorn extracted from hawthorn leaves, which has been recorded in the 2000 edition of the Chinese Pharmacopoeia, page 563. [0004] Added sodium carboxymethyl starch: refers to the sodium carboxymethyl starch added when preparing Yixindone disintegrating particles, which is included in each disintegrating particle. [0005] Added sodium carboxymethyl starch: refers to the prepared Yixindone disintegrating particles. When preparing Yixindone dispersible tablets, carboxymethyl starch sodium is added again, which is outside of each Yixindone disintegrating particles , distributed between each disintegrating particle. [0006] Yix...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/734A61K9/20A61P9/00
Inventor 丁杏苞王晓静杜成林孙敏跃唐文昭
Owner INST OF PHARMACY SHANDONG PROV ACAD OF MEDICAL SCI
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