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Acetyl salicyl sulfonone oral cavity disintegration tablet and its preparation method

A technology of orally disintegrating tablets and flavone, which is applied in the field of preparation of the orally disintegrating tablets of flavone, can solve problems such as low dissolution rate, long dissolution time limit, and influence on drug efficacy, and achieve good taste, short time, etc. The effect of disintegration time

Inactive Publication Date: 2007-01-24
COSCI MED TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, due to preparation technology and other reasons, most common oral preparations have problems such as long dissolution time, low dissolution rate, poor absorption and low bioavailability after taking them, which affect the efficacy of the drug and directly affect the The effect of treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] 1. Prescription

[0057] 1. Raw material - acetaloflavone 100.0g;

[0058] 2. Filler - microcrystalline cellulose 140.0g;

[0059] Mannitol 860.0g;

[0060] 3. Disintegrant—cross-linked polyvinylpyrrolidone 120.0g;

[0061] Low-substituted hydroxypropyl cellulose 180.0g;

[0062] 4. Flavoring agent - aspartame 20.0g;

[0063] 5. Lubricant—magnesium stearate 13.0g;

[0064] A total of 10,000 pieces were made

[0065] 2. Preparation method

[0066] The first step is to take 140g of acetaloflavone and microcrystalline cellulose and put it into a stirring granulator to stir evenly, use 5% povidone ethanol as a binder, and use a stirring granulator to make granules, and the granules are dried and passed through a 30-mesh sieve Whole grain;

[0067] The second step is to weigh and mix the prepared granules with mannitol, cross-linked polyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, and aspartame according to the amount, and finall...

Embodiment 2

[0070] 1. Prescription

[0071] 1. Raw material - acetaloflavone 100.0g;

[0072] 2. Filler - microcrystalline cellulose 260.0g;

[0073] Mannitol 1240.0g;

[0074] 3. Disintegrant—cross-linked polyvinylpyrrolidone 200.0g;

[0075] Low-substituted hydroxypropyl cellulose 250.0g;

[0076] 4. Flavoring agent - aspartame 15.0g;

[0077] 5. Lubricant—magnesium stearate 15.0g;

[0078] A total of 20,000 pieces were made

[0079] 2. Preparation method

[0080] The technological process of embodiment 2 is identical with embodiment 1.

Embodiment 3

[0082] 1. Prescription

[0083] 1. Raw material - acetaloflavone 100.0g;

[0084] 2 filler - mannitol 1100.0g;

[0085] Microcrystalline Cellulose 240.0g

[0086] 3. Coating material - Eudragit  E100 20.0g;

[0087] Eudragit  NE-30D 3.0g

[0088] 4. Glidant—micronized silica gel 10.0g;

[0089] 5. Disintegrant—cross-linked polyvinylpyrrolidone 140.0g.

[0090] Low-substituted hydroxypropyl cellulose 160.0g

[0091] 6. Flavoring agent - aspartame 15.0g;

[0092] 7. Lubricant—magnesium stearate 10.0g;

[0093] A total of 20,000 or 10,000 pieces are made

[0094] 2. Preparation method

[0095] The first step is to take Eudragit  Dissolve E100 in ethanol and add Eudragit  Stir NE-30D evenly, and dilute it to 6% with ethanol, and use it as a coating solution for later use.

[0096] The second step is to mix acetaloflavone and micropowder silica gel, put it in a fluidized bed to boil, and then spray the coating liquid at an...

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Abstract

An oral disintegrating tablet of flavone aspirin for treating coronary heart disease, angina pectoris, myocarditis, ischemic heart disease, hyperlipemia, etc is disclosed. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to an orally disintegrating tablet of flavonoids in the field of pharmaceutical preparations, which can be used to treat cardiovascular and cerebrovascular diseases, especially coronary heart disease, angina pectoris, myocarditis complicated by cardiac insufficiency, ischemic heart disease, and hyperlipidemia syndrome and hyperviscosity. The present invention also relates to a preparation method of the orally disintegrating tablet of aceflavone. Background technique [0002] Acetaloflavones are flavonoids extracted from Hippophae rhamnoides L., a plant of the family Echinaceae. Seabuckthorn is the main distribution area of ​​Hippophae rhamnoides in the northeast, north, northwest and southwest of China. . Seabuckthorn fruits and leaves contain flavonoids, and the total content of flavonoids in leaves is higher than that in fruits. The flavonoid compounds that have been identified include: quercetin, isorhamnetin, kaempferol and...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K9/20A61P9/10A61P9/00
Inventor 蒋海松王锦刚
Owner COSCI MED TECH CO LTD
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