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Rapidly-dispersible tablet and preparation method thereof

A tablet and dispersing technology, applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, and pill delivery, etc., can solve the problems of only swallowing, long duration of drug effect, slow dissolution rate, etc. To achieve the effect of convenient storage and carrying, accurate dosage and stable quality

Inactive Publication Date: 2018-03-23
北京素维生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional tablets contain disintegrants, which can be quickly dispersed. However, most of the existing disintegrants are poorly soluble in water. Taking it, a large amount of insoluble disintegrants are suspended in water, increasing the turbidity of the liquid and bringing bad user experience
However, the commonly used tablets without disintegrants have a slow dissolution rate, which not only achieves the drug effect for a long time, but also is not easy to dissolve in water, which is only conducive to swallowing, not conducive to children, the elderly or comatose patients who have difficulty swallowing.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] 1. Prescription

[0035] Lycopene 600g; L-carnitine 5g; Sorbitol 500g; Stearic acid 10g; Micronized poloxamer 10g; Cyclamate 30g; Hydroxypropyl cellulose 18g; Hydroxypropyl methylcellulose 7.2 grams of elemental, 1 gram of vinylpyrrolidone, 1.8 grams of glycerin, 1 gram of Tween, 0.6 grams of titanium dioxide, and 0.5 grams of pigment.

[0036] 2. Preparation method

[0037] Pass lycopene, L-carnitine, sorbitol, and cyclamate through an 80-mesh sieve, weigh the sieved raw materials according to the formula, put them into a closed fluidized bed, and perform fluidization to mix the powder evenly. Start the spraying device, spray into the hydroxypropyl cellulose aqueous solution (concentration is 15%), and the droplets condense on the powder until the required particle size is 20 mesh and stop spraying. Finally, the granules are dried. Then the granule is mixed with stearic acid and micronized poloxamer, and the tablet weight of the tablet press is adjusted to be 1.5 gr...

Embodiment 2

[0039] 1. Prescription

[0040] 8 grams of lutein; 400 grams of vitamin E; 600 grams of sorbitol; 15 grams of stearic acid; 45.5 grams of sucrose.

[0041] 2. Preparation method

[0042] Weigh lutein, vitamin E, sorbitol, and stearic acid according to the formula and mix them evenly. Put the mixture in a tablet machine, adjust the tablet weight to 1.5 grams, and press it directly. After making tablets, wrap sugar-coated .

Embodiment 3

[0044] 1. Prescription

[0045] 1 gram of melatonin; 700 grams of mannitol; 20 grams of stearic acid; 11.5 grams of povidone.

[0046] 2. Preparation method

[0047] Melatonin and mannitol are passed through 80 mesh sieves, and the raw materials weighed are put into a wet granulator container and mixed uniformly by weighing the raw materials after the sieving according to the formula, and sprayed into the povidone aqueous solution (the concentration of the povidone aqueous solution is 10%), while the material is vigorously stirred and chopped into particles by a cutting knife. The granules are sent to a granulator to crush oversized agglomerates, passed through a 20-mesh sieve, and then sent to a fluidized bed for drying to obtain granules. Then the granules are mixed with stearic acid, and the tablet weight of the tablet press is adjusted to be 0.8 g, and the tablet is directly compressed to make a tablet.

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PUM

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Abstract

The invention relates to a rapidly-dispersible tablet and a preparation method thereof, in particular to a rapidly-dispersible tablet composition containing no disintegrating agent and a preparation process thereof, which belong to the field of drugs and healthcare products. The invention discloses a rapidly-dispersible tablet. The rapidly-dispersible tablet is prepared from 0.5 to 900 parts by weight of active components, 200 to 900 parts by weight of excipient and 5 to 30 parts by weight of lubricating agents, wherein the active component is a water-insoluble active component. The rapidly-dispersible tablet has the advantages that the rapidly-dispersible tablet composition containing insoluble active component is prepared into the tablet rather than a liquid dosage form, so that a complex process for preparing the insoluble active component into the liquid preparation is not needed, the layering phenomenon of the product liquid during a long-term storage period can also be avoided, and the rapidly-dispersible tablet has accurate dose and stable quality, is convenient to store and carry, can be swallowed and can also be administered after being dissolved.

Description

technical field [0001] The invention relates to a rapidly dispersible tablet and a preparation method thereof, in particular to a tablet composition containing no disintegrating agent, rapidly dispersible, and water-insoluble active ingredients and a preparation process thereof, belonging to the field of medicines and health care products . Background technique [0002] In the current field of medical and health care products, there are many types of dosage forms, each of which has its own advantages and disadvantages. Compared with other dosage forms, solid dosage forms have many advantages and are widely used. The dosage of the solid dosage form is accurate, and the difference in the content of the drug is small; the solid dosage form is a dry solid, and some drugs that are prone to oxidative deterioration and deliquescence can be protected by coating, so light, air, moisture, etc. have little influence on it, and the quality Stable; mechanized production of solid dosage...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/10A61K47/26A61K47/36A61K47/38A61K47/12A61K47/20A23L33/00A23P10/28A23P10/25A61K31/205A61K31/355A61K31/4045A61K31/01A61K31/047
CPCA23L33/00A23P10/25A23P10/28A61K9/2013A61K9/2018A61K9/2031A61K9/2054A61K9/2059A61K9/2095A61K31/01A61K31/047A61K31/205A61K31/355A61K31/4045A61K2300/00
Inventor 许伯慧韩闪闪佘佐彦
Owner 北京素维生物科技有限公司
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