212results about How to "High specific activity" patented technology

The invention is directed to core / shell type catalyst particles comprising a Mcore / Mshell structure with Mcore=inner particle core and Mshell=outer particle shell, wherein the medium diameter of the catalyst particle (dcore+shell) is in the range of 20 to 100 nm, 5 preferably in the range of 20 to 50 nm. The thickness of the outer shell (tshell) is about 5 to 20% of the diamet the inner particle core of said catalyst particle, preferably comprising at least 3 atomic layers. The inner particle core (Mcore) of the particles comprises metal or ceramic materials, whereas the material of the outer shell (Mshell) comprises precious metals and / or alloys thereof. The core / shell type catalyst particles are preferably supported on suitable support materials such as carbon black and can be used as electrocatalysts for fuel cells and for other catalytic applications.

The present invention provides a recombinant α-L-iduronidase and biologically active fragments and mutants thereof, methods to produce and purify this enzyme as well as methods to treat certain genetic disorders including—α-L-iduronidase deficiency and mucopolysaccharidosis I (MPS 1).

There is provided an electrode catalyst layer that has excellent durability compared to conventional electrode catalyst layers employing carbon supports, and that can minimize as much as possible the amount of catalyst material used while exhibiting desired output, by allowing adjustment of the amount as necessary. The electrode catalyst dispersion of the disclosure comprises catalyst particles that contain a non-conductive support and a conductive catalyst material covering the surface of non-conductive support, and a dispersing medium selected from among water, organic solvents and combinations thereof. The ink composition of the disclosure comprises catalyst particles containing a non-conductive support and a conductive catalyst material covering the surface of non-conductive support, a dispersing medium selected from among water, organic solvents and combinations thereof, and an ionic conductive polymer, wherein the volume ratio of the catalyst particles and the ionic conductive polymer is 55:45-90:10. There is further provided an electrode catalyst layer.

The invention discloses core / shell type catalyst particles comprising a Mcore / Mshell structure with Mcore=inner particle core and Mshell−outer particle shell, wherein the medium diameter of the catalyst particle (dcore+shell) is ≧20 nm. The thickness of the outer shell (tshell) comprises at least 3 atomic layers. The core / shell type catalyst particles, particularly the particles comprising a Pt-based shell, reveal a high specific activity. The catalyst particles are preferably supported on suitable support materials such as carbon black and are used as electrocatalysts for fuel cells.

The invention belongs to the field of macromolecule preparation, relates to decontaminant-doped dry hydrogel particles and a method for realizing mass concentration of a macromolecular liquid sample and specific activity improvement of a protein liquid sample by utilizing the decontaminant-doped dry hydrogel particles, and overcomes the defects of low efficiency, active function loss and the likein the prior art. The decontaminant-doped dry hydrogel particles are suitable for treatment of various sizes of macromolecular liquid samples. The hydrogel particles sufficiently suspend and are hydrated in a decontaminant solution, unnecessary decontaminant solution is filtered off, and then the particles are dried to obtain the decontaminant-doped dry hydrogel particles. The dry particles with cross-linked network apertures smaller than target macromolecules are enabled to contact with the macromolecular liquid sample proportionally, the hydrogel particles after imbibition are subjected to filtering centrifugation or conical filter membrane drum centrifugation so as to remove surface layer- dehydrated hydrogel particles, and then macromolecular mass concentrated filter liquid or proteinspecific activity improved concentrated filter liquid is obtained.

This invention relates to a process for the preparation of a very high purity von Willebrand factor concentrate from a biological fraction containing von Willebrand factor, including a separation by anion exchange chromatography using a vinyl polymer support of weak base type, the separation comprising the steps of loading of the chromatographic support with the fraction containing von Willebrand factor, previously equilibrated with a suitable buffer, with a predetermined flowrate allowing the retention of the von Willebrand factor, washing of the support with an acidic buffer with a flowrate higher than the flowrate of the step a) until the not-retained proteins and the contaminants are removed, flushing and equilibrating of the chromatographic support with the buffer and using the flowrate of the step a), and elution of the von Willebrand factor by increasing of the ionic strength of the step c). The invention also relates to a von Willebrand factor concentrate for therapeutic use likely to be obtained by implementing the process wherein the rate of Factor VIII:C / FvW:RCo is less than 0.06%.