The present invention belongs to the field of food-derived peptides and discloses a collagen peptide, a production method, a production device and an application thereof. The production method of thecollagen peptide comprises steps of coarse collagen solution heating, cooling, high-efficiency compound enzyme preparation enzymatic hydrolyzing, membrane filtering, concentrating, ultra-high pressurehomogenizing, and ultra-high temperature instantaneous sterilizing and drying. The high-efficiency compound enzyme preparation enzymatic hydrolyzing uses a compound enzyme preparation comprising compound protease, alkaline protease, neutral protease, flavor protease, animal proteolytic enzyme and an enzyme activator, and the enzyme activator is dithiothreitol and / or beta-mercaptoethanol. The provided method does not need to adjust pH value of the enzymatic hydrolyzing, does not need to control enzymatic hydrolyzing temperatures, is short in enzymatic hydrolyzing time and small in enzyme addition amount, and enables the enzymatic hydrolyzed product to be low and concentrated in molecular weight. The prepared collagen peptide powder is free of fishy smell, extremely excellent in water resolubility and also not liable to absorb moisture and agglomerate during storage process, and can be used in solid beverages, effervescent tablets, chewable tablets, health-care foods and feature-beautifying and skin-protecting products.