The invention relates to yak milk powder for reducing hypertension, hyperlipidemia and hyperglycemia and a preparation method of the yak milk powder. The yak milk powder capable of reducing hypertension, hyperlipidemia and hyperglycemia is prepared from the raw materials of whole milk powder, demineralized whey powder, whole milk powder, inulin, concentrated whey protein powder, calcium carbonate, yeast beta-glucan, rhizoma polygonati powder, sea-buckthorn powder, semen cassiae powder, Chinese yam powder, radix polygonati officinalis powder, walnut peptide, wheat oligopeptide, fructus lycii peptide, compound vitamins, compound minerals, and bifidobacterium animalis Bb-12 which are prepared according to a proper weight ratio. During preparation, firstly, milk powder base powder is prepared by adopting a wet process, then the prepared milk powder base powder is subjected to dry mixing with other auxiliary materials and bioactive substances by adopting a dry process, and finally, the yak milk powder capable of reducing hypertension, hyperglycemia and hyperlipidemia is prepared. The yak milk powder has high cholesterol and triglyceride degradation capability, alpha-glucosidase and alpha-amylase inhibition capability, reducing power, hydroxyl free radical scavenging capability and DPPH scavenging rate, so that the yak milk powder has a good function of reducing hypertension, hyperlipidemia and hyperglycemia.