332 results about "Personalized treatment" patented technology

The present invention relates to genetic profiles and markers of cancers and provides systems and methods for screening drugs that are effective for specific patients and types of cancers. In particular, the present invention provides personalized treatment customized to an individual's cancer.

A patient treatment method is provided. In one embodiment, the method includes inputting physiological data of a patient into a computer model that is configured to simulate a physiological activity of the patient. The method may also include operating the computer model for each of a plurality of potential treatment options to generate a plurality of personalized modeled results based at least in part on simulated effects of each potential treatment option on the physiological activity. Additionally, the method may include selecting an optimal treatment option from the plurality of potential treatment options based at least in part on the plurality of personalized modeled results, developing a personalized treatment plan comprising the optimal treatment option, and treating the patient based at least in part on the personalized treatment plan. Other methods, systems, and computer-readable media are also disclosed.

The invention provides a similarity analysis method and system for patients suffering from cardio-cerebral vascular diseases. The method comprises the following steps of 1 problem definition, wherein problem definition for the patients suffering from the cardio-cerebral vascular diseases is conduced; 2 data collection, wherein health care data of the patients suffering from the cardio-cerebral vascular diseases is collected; 3 data preprocessing, wherein data integration, data cleaning, missing value processing, feature deleting and abnormal point removing are included; 4 feature engineering, wherein feature construction, feature selection and feature processing are included; 5 patient clustering modeling; 6 diagnosis and treatment scheme recommendation. Accordingly, an effective similarity analysis model for the patients suffering from the cardio-cerebral vascular diseases is built, a clinician can obtain the similar populations of a give patient through the patient features and then recommends a personalized treatment plan to achieve the purpose of accurate medical treatment, population grouping based on similarity analysis can be well conducted on the patients suffering from the cardio-cerebral vascular diseases in the Chinese population, and pointed personalized rehabilitation therapy is conducted on different risk populations as early as possible.

Systems and methods for treatment for addiction to a substance according to a predetermined action plan that includes a message control center for sending information to a messaging-accessible device associated with a user, an analyzer for analyzing an indicia of use of said substance, and a personalized treatment engine to receive an output from the analyzer and to direct the message control center based, at least in part, on the output from the analyzer and the predetermined action plan for the user.

The invention discloses a cloud computation based early oncotherapy efficacy evaluation system and method. The system comprises a multimodal imaging acquisition device in the oncotherapy process, a voxel-based multimodal image registration and fusion cloud computation device, a voxel-based early evaluation cloud computation device for efficacies in the oncotherapy process, and a posttreatment cloud computation evaluation device. The system and method provides more accurate, reliable and real-time information abundant in information amount to doctors, and accurate bases are provided for establishing patient-orientated personalized treatment programs. By establishment of a molecular image guided early oncotherapy efficacy evaluation cloud system with high-speed processing capacity, a posttreatment historical data reference platform is provided for medical staff, and a platform used for providing bases to timely adjustment, fast tracking or implementation of treatment schemes on the basis of real-time data in the current treatment course can be provided.

Embodiment of the present invention disclose a method of managing treatment comprising capturing images of an organ, analyzing the captured images, determining at least one of susceptibility to at least one of a medical and non-medical condition and presence of the at least one of medical and non-medical condition, upon determination of the presence of at least one of medical and non-medical condition, measuring the level of severity of the at least one of medical and non-medical condition, categorizing the at least one of medical and non-medical condition based on the measured level of severity, recommending one or more of at least one of preventive, palliative, curative and cosmetic cum aesthetic, and at least one of new and enhanced personalized treatments based on the measured level of severity of the at least one of medical and non-medical condition, implementing the one or more of at least one of preventive, palliative, curative and cosmetic cum aesthetic, new and enhanced personalized treatments, tracking efficacy of the implemented one or more of at least one of preventive, palliative, curative and cosmetic cum aesthetic, new and enhanced personalized treatments and optimizing the one or more of at least one of preventive, palliative, curative and cosmetic cum aesthetic, new and enhanced personalized treatments based on the efficacies thereof.

The invention belongs to the technical field of medicine, and specifically relates to a primary tumor cell culture medium, culture method and application. The primary tumor cell culture method provided by the invention comprises the steps as follows: preparing a primary cell culture medium which comprises the following components: hydrocortisone, EGF, Insulin, a ROCK inhibitor, but not contains cholera toxin, and is an improvement of the existing primary cell culture medium; culturing tumor tissue epithelial cells on laid-out trophoblast cells by using the primary cell culture medium, and enabling the tumor tissue epithelial cells to proliferate rapidly under the combined action of growth factors secreted by the trophoblast cells and nutrient factors contained in the culture medium; and digesting and sub-culturing the tumor tissue epithelial cells when the tumor tissue epithelial cells grow to a cell density of about 80% to 90%. A convenient primary cell culture method is used to obtain immortalized cells possessing the biological characteristics of a patient's own tumor, and the problem of immortalization of the primary culture of tumor cells is solved, thereby realizing personalized treatment for the patient.

The invention provides a screen unlocking method and a data access control method. The data access control method comprises the following steps: collecting signature characteristics input by a user in advance, structuring signature essential information corresponding to a collection environment and storing the information; and when screening unlocking or access of limited sensitive data or application is required, collecting a current signature characteristic input by the user, extracting stored signature essential information correspondingly to a current collection environment according to the collection environment, comparing the current input signature characteristic with the extracted signature essential information to perform screen unlocking or allow the sensitive data or the application to be accessed if the comparison is identical, and otherwise, not performing screen unlocking or refusing accessing the sensitive data or the application. According to the invention, screen unlocking is realized, and personalized treatment on control of the data access is achieved, and the safety is improved.

The invention discloses a pharmaceutical activity prediction and selection method based on genetic expressions and drug targets. The method comprises following steps: 1) obtaining target genes corresponding to drugs to be detected according to information in drug target database; obtaining genetic expression data of disease tissues of patients and corresponding compression data and obtaining important genetic lists of morbidity processes of patients by evaluating importance of genes through a systems biology method; 2) searching for whether the target genes obtained in the step 1) target the important gene lists during mobility of the patients or not through statistical analysis of in order to predict pharmaceutical activity of patients and select drugs suited to patients. The method is easily used with high efficiency and broad application scope. The prediction method can be used for selecting drugs suitable for individual patients such that a personalized treatment schme can be provided for patients.

Personalized skin-specific topical formulations containing conditioned medium obtained from cultures of fibroblasts has been developed. Unlike other topical formulations, these formulations are specific for the recipient-skin type specific, and conditioned medium is obtained from a subject with desired skin characteristics. For example, since African American skin is known to wrinkle less and later than Caucasian skin, conditioned medium may be obtained from African American skin for application to pale skin. In another embodiment, the fibroblasts are obtained from young skin for administration to older skin. In still another embodiment, the fibroblasts are obtained from skin that does not suffer from acne or discoloration, for application to skin that is prone to acne or discoloration. Examples of skin donor selection criteria include delayed wrinkling, small pores, resistance to sunburn, resistance to acne, uniform coloration or lack of blotching or age spots and good moisture retention.

The invention discloses a liver cancer gene detection kit, which comprises 97 target probes matching with the exon regions of 94 liver cancer associated genes and 3 promoter regions of TERT gene. The invention also discloses application of the kit in diagnosis of liver cancer, and a method for detection of liver cancer associated genes with the kit. The liver cancer gene detection kit provided by the invention can be used for clinical diagnosis and classification of liver cancer, makes liver cancer diagnosis rapider and more accurate, and provides a new way for personalized treatment of liver cancer.

The present invention discloses a near-infrared signal-controlled transcranial magnetic stimulation device, comprising a positioning cap, a fNIRS signal acquisition system arranged on the positioning cap, a TMS system and an analysis control device which is connected to the TMS system and the fNIRS signal acquisition system. The near-infrared signal-controlled transcranial magnetic stimulation device utilizes the near infrared signal of the subject to set personalized transcranial magnetic stimulation parameters, avoiding over stimulation or under stimulation. The near-infrared signal-controlled transcranial magnetic stimulation device is simple and easy to operate, is easy to adjust transcranial magnetic stimulation parameters according to the real-time near-infrared signal in transcranial magnetic stimulation to meet the demand of personalized treatment, enhances the stimulation effect of transcranial magnetic stimulation and expands the application scope of near-infrared signal detection, so as to provide a new method and practical tool for neuroscience research, testing and treatment.

A visual distortion test is disclosed using a sequence of binary interactions with a mobile device, in which segments of the grid having no distortions are eliminated, and the segments with distortions are divided into smaller segments for further analysis. The test can quantify the visual distortion using a decreased number of steps, compared to sequential analysis of all the segments of the grid. The binary interaction or input to the mobile device is also easier for patients than graphic interactions with a conventional Amsler Grid. Early detection of changes in the visual distortion can enable the healthcare provider to individualize treatment, helping to prevent vision loss while minimizing visits to the office, discomfort, and expense.

The invention relates to a method for analyzing the correlation between CT imaging genomics characteristics and gene expression in lung cancer. The method includes: using a semi-automatic segmentationmethod to extract CT imaging genomics characteristics of a segmented tumor were; performing clustering analysis on the basis of preprocessed gene data, and taking a first principal component as a representative of a gene clustering result with a similar expression profile; and finally, using a gene chip saliency analysis algorithm to find the correlation between CT imaging genomics characteristics and gene expression in lung cancer, and verifying and analyzing the result. The invention provides a novel scheme for exploring the relationship between the image characteristics and the gene data,and attempts to find an imaging substitute of the gene, interprets the image characteristics from the gene level, and assists the personalized treatment of the tumor well.

The invention discloses an ICU ward horizontal-type bilateral cerebral palsy lower limb rehabilitation robot with the functions of communication and autonomous navigation movement. The robot structurally comprises a lower limb rehabilitation exoskeleton, a human body sign data collection module, a data processing module, a human-computer interaction module, a motion control module and an autonomous navigation moving chassis, and evaluation and coordinated rehabilitation training on all joints of the two lower limbs can be achieved; the data collection module collects motion and physiological data of the joints of the lower limbs and sends the data to the data processing module, the data processing module gives out a rehabilitation evaluation result of a patient and related motion data anduploads the result and the data to a cloud platform, and the cloud platform generates a personalized treatment scheme through clustering analysis; the human-computer interaction module sends an instruction to the motion control module to control the lower limb exoskeleton and guide the patient in rehabilitation training; the autonomous navigation moving chassis adopts Mecanum wheel design, indoorand outdoor navigation is achieved through the combination of GPS, vision and laser navigation, obstacle avoidance is achieved through ultrasonic detection, and the autonomous moving capability of therobot is improved.

The invention provides a java-based web development middleware. The java-based web development middleware comprises an action module and a data access module, wherein the action module is in charge of receiving http request data, sending the data to an appointed logic treatment unit for processing, generating webpage data in required format for treatment results of corresponding logic treatment units, and displaying the webpage data in a browser; the data access module is in charge of receiving and executing an operation request on a database, achieving automatic mapping of the database and a javabean object by utilizing an MQL (MetaQuotes Language) script language, and converting the complex operation on the database into the operation on the javabean object; in the logic treatment process, the need of personalized treatment is met in a way of inserting an interceptor; and in the webpage generation process, a template mode and a non-template mode are provided at the same time, and in the template mode, a webpage generation format is defined by a template based on an XML (Extensive Markup Language) marking mode. By utilizing the development middleware, the web development process is flexible and quick, the complex database operation is simplified, the web development cycle can be shortened, and the development efficiency is improved.

Described herein are gene signatures providing prognostic, diagnostic, treatment and molecular subtype classifications of ovarian cancers through generation of ovarian cancer disease signatures (OCDSs) that account for molecular heterogeneity present in gynecological cancers. An ovarian cancer fixed signature (OCFS) is described which relates to the core programming of disease development, in addition to an ovarian cancer stem cell (OCSC) signature. Development various disease signature, suggests personalized treatment strategies focused on molecular subtypes of gynecological cancers, such as triage tests for patients.

A therapy table / chair device having integrated therewith a head rest support and body supports and wherein the head rest support provides face exposure to a sensory generating housing through an opening in the head rest support. The sensory generating housing has at least one or a combination of facial applied therapies including lumino therapy, audio therapy, aroma therapy, ozone, steam and oxygen injectors with or without scented essences. The body supports are part of a massage table and are provided with at least one or a combination of vibration, magnetic field and heat therapy. A controller controls all of these therapies and an interface permits the selective operation thereof. The therapy table / chair is also integratable in a personalized therapeutic treatment home spa which is interfaced with a commercially operated spa offering therapeutic services to the household spa. Communication between the commercially operated spa and the household spa is effected through an internet link and computers.

The invention provides a design method of a personalized 3D printing calcaneal plate based on topological optimization. The design method comprises the steps that firstly, three-dimensional reconstruction of a calcaneal model is conducted; then, a calcaneal outer side curved surface contour is extracted and constructed, construction of a calcaneal curved surface plate prototype and configuration of screws are conducted, and finite element analysis and topological optimization redesigning of a calcaneal prototype plate are conducted; and finally, 3D printing forming is conducted. According to the design method, based on the personalized treatment principle, limitation of traditional design and manufacturing technologies is broken through, the calcaneal height and reposition flatness of thearticular surface are effectively recovered, anatomic form matching and maximization of the fixation rigidity are achieved through combination of 3D printing and personalized manufacturing, and accordingly, the effect of calcaneal fracture plate internal fixation treatment is improved. According to the calcaneal plate designed through the design method, the problems of personalized anatomical compatibility difficult to achieve in a traditional calcaneus internal fixation plate, insufficient fixation stability and complications of related soft tissue of implantation materials are solved, shaping is easy, incisures are lower, biomechanical stability is better, and the risk of post-operation skin flap necrosis is lower.

Disclosed is a personalized diagnostic and treatment solution for cardiovascular disease. The invention comprises an extended CVD risk assessment panel, combining tests for traditional and new important risk markers, and methods for devising a personalized treatment plan for a patient via the use of a CVD diagnosis and treatment protocol algorithm. The new important risk markers include HDL subpopulation profile by two-dimensional gel-electrophoresis, plasma sterols, direct measurement of sdLDL-C, determination of CRP molecular forms, glycated albumin as a percentile of total albumin, and other specialized testing pertaining to apolipoprotein E and Factor V Leiden genotyping, NT-proBNP and adiponectin. This solution provides a more complete risk assessment of an individual than merely measuring traditional CVD risk markers, and enables the healthcare practitioner to optimize therapy for patients with or without established CVD. This solution presents the advantages of greater accuracy, savings in time and cost over existing testing and treatment methods.

It is described a drug delivery system (100) that is adapted to infuse at least one drug in a profile related to the status of a patient. The system comprises sensors (110), dedicated electronics (140) and software to monitor the patient's activity and maintain control over the drug-release profile. A control unit (120) of the system (100) is adapted to temporarily set at least one component (110, 120, 150) of the system (100) in an idle mode (265). This will result in particular in a reduction of power required by the system (100). The described system (100) enables a personalized treatment of patients by monitoring their individual activity status and coupling this information to a drug delivery following appropriate delivery profiles. The system (100) may be provided with a memory in order to store a time dependence of activity data. This time dependence may be used by physicians to monitor, support and adapt their therapy for the patients. The system (100) may be realized as a closed-loop system for monitoring and treatment of various diseases such as hemophilia A and Parkinson.

A tumor molecular typing prediction system comprises a gene expression data extraction module, a missing value preprocessor, an important gene extraction module and a US-ELM (Extreme Learning Machine) molecular typing module, wherein the gene expression data extraction module is used for obtaining tumor gene expression data; the missing value preprocessor is used for filling the obtained tumor gene expression data with missing values; the important gene extraction module is used for extracting important tumor genes determining survival time from the tumor gene expression data; the US-ELM molecular typing module is used for performing tumor molecular typing prediction on the important tumor genes by adopting US-ELM. The tumor molecular typing prediction system overcomes the defects of slow speed, poor generalization performance and low classification accuracy of conventional tumor molecular typing techniques, realizes tumor molecular typing prediction which is rapid and high in classification accuracy, and can perform unsupervised machine learning on multiple types of tumors. By the application of the system in tumor molecular typing prediction, biological behaviors of the tumors can be better judged, and the direct purpose of the system is to provide the reference base for formulation of personalized treatment programs instead of obtaining a diagnosis result.

The invention discloses a neonatal jaundice blue light therapy incubator and a monitoring management system thereof. The neonatal jaundice blue light therapy incubator comprises a neonatal jaundice blue light therapy incubator body, a mobile terminal in communication connection with the neonatal jaundice blue light therapy incubator body, and a remote server in communication connection with the mobile terminal. The neonatal jaundice blue light therapy incubator solves the problem of individual-based jaundice treatment, so that the treatment process is more scientific and more effective, and the side effects generated from treatment are reduced. Remote control over the neonatal jaundice blue light therapy incubator is achieved, a medical worker can conveniently use the incubator, and the treatment risk is reduced. Standard management of jaundice treatment is achieved, a treatment scheme is completely recorded and uploaded to a far-end server, and contrastive analysis of the treatment effect and tracing are convenient. The effect that one management system manages multiple jaundice therapy incubators is achieved, and the work efficiency of medical workers is greatly improved.

Methods and apparatuses for sensory electrical stimulation of the peripheral nervous system to improve human motor function and performance are described. Methods and devices may be used to enhance physical performance of athletes, professionals, and gamers or improve motor function (hand, finger and limb movement) in patients rehabilitating from neurological deficits and impairments caused by stroke, traumatic brain injury and other neurologic or non-neurologic conditions. These apparatuses and methods may be used for physical training and mental training (to improve memory and functional performance including motor coordination, limb-eye coordination, occupational and recreational skills) through periodic or sustained sensory electrical stimulation. Treatment plans may be based on biomarkers and may be used alone or in combination with other apparatuses. Learning and feedback techniques individualize treatment parameters depending on the subject's neurologic and motor function in diseased patients and healthy users.

The present invention relates to organoids derived from a single cell, such as a prostate cancer cell, and methods and compositions relating to the production and use thereof, including cell culture medium for producing organoids and methods of personalized treatment for prostate cancer. The invention further provides a humanized mouse comprising a prostate organoid derived from a patient's prostate cell.

The invention relates to the technical field of detection of rare cells, in particular to a microfluid control system for separating, focusing and sorting of rare cells and application. A microfluid control chip device comprising a separating unit, a focusing unit, a sorting unit and a flow resistance matching unit serves as the core of the system. The system is characterized in that the system can integrate operation like separation, focusing, single-cell analysis and sorting on the rare cells in body fluid such as blood in a continuous mode on one chip for completion, and therefore, the system can be widely applied to separation and sorting of the rare cells in the body fluid, and disease diagnosis, drug screening, individual-based treatment and other fields based on the rare cells.

The invention provides a method for detecting pathogenic genes of other system diseases causing cardiovascular symptoms, and provides application of a reagent for detecting pathogenic and / or susceptible genes of other systemic diseases causing cardiovascular symptoms in preparing products for diagnosing other systemic diseases causing the cardiovascular symptoms. The reagent can detect at most 263diseases related genes simultaneously, and a reference can be provided for genetic diagnosis and personalized treatment of sick individuals so as to study causes of other systemic diseases causing the cardiovascular symptoms and to assess risk factors for early intervention and early treatment.

A system for individualized treatment of a tissue condition with acoustic pressure shocks includes personalized determination and automatic adjustment of a shock wave treatment regimen or shock wave dosage to be administered for personalized treatment based on factors such as a patient's comorbidities, state of the tissue condition, individual physical characteristics and lifestyle parameters.

The invention discloses an 18F labeled quinazoline class EGFR (Epidermal Growth Factor Receptor) positron tracer agent and a preparation method and application thereof and belongs to the field of chemical synthesis. The 18F labeled quinazoline class EGFR positron tracer agent has a chemical structure as shown in a formula II. The synthesized 18F labeled micro-molecular EGFR class positron tracer agent has the clinic values of diagnosis and therapeutic effect monitoring and particularly plays an important role in promoting personalized treatment. Besides, the invention further provides a one-step method, namely a method for fully-automatically synthesizing the 18F labeled quinazoline class EGFR positron tracer agent. The method has the characteristics of multiple purposes, high yield, high efficiency, short synthesis time, low cost and the like and can meet the requirements of large-scale production. The formula II is shown below.

The invention discloses a liver cancer marker lncRNA ENST00000620463.1 and application thereof. The invention provides a tumor marker which is LncRNA; the tumor marker is named as ENST00000620463.1; the ENST00000620463.1 is RNA expressed as a sequence 1 in a sequence table; DNA corresponding to ENST00000620463.1 is DNA expressed as a sequence 2 in the sequence table. The invention firstly discovers that the ENST00000620463.1 in the liver cancer is greatly increased; an experiment proves that shRNA interference silencing ENST00000620463.1 is capable of effectively inhibiting proliferation, migration and invasion of the liver cancer cells; a novel method is provided for the individualized treatment of the liver cancer.