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Application of donkey-hide gelatin to preparing drugs or health-care products for treating premature ovarian failure

A technology for ovarian function and health care products, which is applied in the directions of drug combination, function of food ingredients, medical preparations containing active ingredients, etc., to achieve the effect of treating premature ovarian failure

Inactive Publication Date: 2016-06-22
SHAN DONG DONG E E JIAO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether donkey-hide gelatin has a preventive effect on premature ovarian failure has not been reported at home and abroad.

Method used

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  • Application of donkey-hide gelatin to preparing drugs or health-care products for treating premature ovarian failure
  • Application of donkey-hide gelatin to preparing drugs or health-care products for treating premature ovarian failure
  • Application of donkey-hide gelatin to preparing drugs or health-care products for treating premature ovarian failure

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0047] Experimental Example 1 Study on the Effect of Ejiao on Premature Ovarian Failure

[0048] 1. Experimental method

[0049] 1.1 Experimental animal feeding and modeling grouping

[0050] 1.1.1 Experimental animal feeding:

[0051] Animal quarantine: Quarantine for 5 days after receiving animals;

[0052] Breeding environment and conditions: SD rats were reared in SPF animal room of Shanghai Institute of Family Planning Science (China Fertility Regulatory Drug Toxicology Testing Center); hours, 12 hours in darkness; quarantined for 5 days before the start of the animal experiment, and adaptively raised until the age and weight of the animals reached the experimental requirements. After general behavior observation, rats that met the requirements were selected as experimental animals; they were raised in 400×350×200mm3 plastic cages , 3 rats of the same sex were raised in each cage; free access to water and food.

[0053] Feed, bedding and drinking water: Feed is breedi...

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Abstract

The invention discloses application of donkey-hide gelatin to preparing drugs or health-care products for treating premature ovarian failure and belongs to the field of new drug application of donkey-hide gelatin. On the basis that a premature ovarian failure animal model is established through cyclophosphamide, influences of donkey-hide gelatin on the weight, the weight increase, the food intake amount, the estrous cycle, the ovary organ coefficient, the sex hormone level, histopathology and follicle counting and the like of premature ovarian failure animals are observed, according to the experiment result, it is found that donkey-hide gelatin has a certain effect on weight restoration of female mice after modeling of cyclophosphamide and has the tendency to increase the ovary and uterus weight and the organ coefficient of male mice, donkey-hide gelatin has a certain forward regulating effect on follicular development, it is shown that donkey-hide gelatin has the effects of increasing the ovary coefficient and enhancing the functions of the ovary, premature ovarian failure can be inhibited, and therefore donkey-hide gelatin can be applied to preparing drugs or health-care products for treating premature ovarian failure.

Description

technical field [0001] The invention relates to new medical uses of donkey-hide gelatin, in particular to the use of donkey-hide gelatin in the preparation of medicines or health care products for treating premature ovarian failure, and belongs to the field of new medical uses of donkey-hide gelatin. Background technique [0002] Premature ovarian failure (POF) refers to ovarian failure and amenorrhea due to depletion of ovarian follicles or iatrogenic damage in women before the age of 40, and is mainly characterized by low estrogen levels and high gonadotropins. According to statistics, the incidence of this disease is between 1% and 3%. The function of ovarian synthetic sex hormones is low or cannot be synthesized, which reduces the negative feedback effect on the pituitary gland, the ovarian reserve follicles are extremely reduced or exhausted, and the ovary develops into atrophic changes. pregnant. In amenorrhea population, its incidence rate is 4%-10%. The natural pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/36A61P15/08A23L33/10
CPCA23V2002/00A61K35/36A23V2200/30A23V2250/204
Inventor 孙祖越周祥山周莉顾建军史兆松
Owner SHAN DONG DONG E E JIAO
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