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Application of seal oil in preparing medicaments for treating sexual disorder

A technology of seal oil and sexual function, which is applied in the field of pharmaceutical preparations and can solve controversial issues such as safety

Inactive Publication Date: 2008-08-13
山东泰洋树生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a chemical prosthesis, the above-mentioned medicines are only used to induce penile erection once, and have side effects of varying degrees, such as flushing, headache, visual disturbance, hypotension, etc., especially for patients with cardiovascular diseases. The safety is controversial. take care

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Take the raw material seal oil, mix it with 0.2 mol / L sodium ethoxide equal to the volume of seal oil, the sodium ethoxide contains 0.005% 2,6-di-tert-butyl-p-cresol, fill it with nitrogen and stir for 10 minutes at room temperature, add ice Acetic acid, adjust the pH value to 7.1, under reduced pressure, remove ethanol by rotary evaporation, and separate and remove the solid therein to obtain ethyl esterified seal oil.

[0051] The EA250-KD200 scraped-film short-path distillation equipment produced by Germany VTA Company is used to carry out molecular distillation of methylated seal oil, including the following steps:

[0052] a) Degassing: Take the esterified seal oil from the previous step and put it in the raw material tank, send it into the degassing tank by the feed pump, degas it under the conditions of temperature 25°C and system pressure 1mbar, and obtain the product of removing very light components Raw material liquid;

[0053] b) Preheating distillation: ta...

Embodiment 2

[0056] Take raw seal oil and mix it with 0.3mol / L sodium methoxide equal to the volume of seal oil. The sodium methoxide contains 0.003% p-hydroxy-tert-butylanisole. After filling with nitrogen and stirring for 10 minutes at room temperature, adjust the pH value to 7.2. Under reduced pressure, methanol was removed by rotary evaporation, and the solid therein was separated and removed to obtain methylated seal oil.

[0057] Apply the wiped film molecular distillation pilot plant equipment manufactured by German VTA company to molecularly distill the methylated seal oil, including the following steps:

[0058] a) Degassing: Take the esterified seal oil from the previous step and put it in the raw material tank, send it into the degassing tank by the feed pump, degas it under the conditions of temperature 30°C and system pressure 2mbar, and obtain the product of removing very light components Raw material liquid;

[0059] b) Preheating distillation: take the raw material liquid ...

Embodiment 3

[0062] Take the raw material seal oil and mix it with 0.4mol / L potassium methylate equal to the volume of the seal oil. Potassium methylate contains 0.001% p-hydroxy-tert-butylanisole. After filling with nitrogen and stirring for 10 minutes at room temperature, adjust the pH to 7.0. Under reduced pressure, methanol was removed by rotary evaporation, and the solid therein was separated and removed to obtain methylated seal oil.

[0063] Apply the wiped film molecular distillation pilot plant equipment manufactured by German VTA company to molecularly distill the methylated seal oil, including the following steps:

[0064] a) Degassing: Take the esterified seal oil from the previous step and put it in the raw material tank, send it into the degassing tank by the feed pump, and degas it under the conditions of temperature 20°C and system pressure 2mbar to obtain very light components raw material liquid;

[0065] b) Preheating distillation: take the raw material liquid obtained ...

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Abstract

The invention relates to an application of fur seal oil which mainly contains EPA, DHA and DPA during the preparing of the medicine for curing sexual disorder, belonging to the field of medicine preparation. The fur seal oil is a fine product obtained through the esterification of the rough fur seal oil and the molecular distillation, wherein, the weight percentages of three omega-3 polyene unsaturated fatty acid are respectively 6.5 to 9.0 percent EPA, 10.5 to 12.5 percent DHA and 4.0 to 8.0 percent EPA. The active ingredient (fur seal oil) of the invention can increase the weight of the gonad of a large male mouse which is weak in sexual ability, increase the plasma stosterone content, prolong the time of the erection of penis, and increase the mating times of the male mouse with the female mouse. Thereby, the invention can improve the erection of penis and better the symptoms of the diseases related to vasoconstriction.

Description

technical field [0001] The invention relates to the application of seal oil in the preparation of medicines for treating sexual dysfunction, and belongs to the field of pharmaceutical preparations. Background technique [0002] The male sexual function is mainly to make the penis erect through the complex physiological reaction of the vascular system under the regulation of the nervous-endocrine system when there are various sexual stimuli. The erection process of this penis first relies on the expansion of the small arteries of the penis to increase the blood flow of the penis, and the smooth muscle of the cavernous body of the penis relaxes one after another to expand the pores of the cavernous body, which promotes the further increase of blood inflow, which leads to blood filling in the cavernous body of the penis And the penis is hard erect. [0003] Sexual dysfunction can be divided into loss of libido, erectile dysfunction, orgasmic disorder and ejaculation disorder. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/12A61K9/06A61K9/107A61K9/12A61K9/20A61K9/48A61P15/08A61K35/35
Inventor 张义兴张智凯
Owner 山东泰洋树生物工程有限公司
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