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Compound medicine for treating chronic liver disease and preparation method thereof

A chronic liver disease and compound technology, which is applied in the field of compound medicine for the treatment of chronic liver disease and its preparation, can solve the problems of large toxic side effects and unsatisfactory effects

Active Publication Date: 2021-03-09
XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effect of clinically applied drugs is still not ideal, and its toxic and side effects are relatively large

Method used

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  • Compound medicine for treating chronic liver disease and preparation method thereof
  • Compound medicine for treating chronic liver disease and preparation method thereof
  • Compound medicine for treating chronic liver disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (Based on the preparation of 1000ml, the oral liquid is prepared and listed in the form of a table)

[0023]

[0024] Mix the screened Tianshan viola, water lily, chicory, chrysanthemum, rose, senna, and aberle, grind to 60 mesh, extract 4 times with 4 times the amount of water, and the temperature is the boiling point of the solvent , each extraction time is 1 hour, precipitated with ethanol, the alcohol precipitation concentration is 40%, filtered, recovered solvent, concentrated, fully mixed with auxiliary materials, sterilized, and canned to make oral liquid.

Embodiment 2

[0026] (Based on the preparation of 1000ml, prepare the mixture and list it in the form of a table)

[0027]

[0028]Mix the screened Tianshan viola, water lily, chicory, chrysanthemum, rose, senna, and aberle, grind to 10 mesh, extract once with 20 times the amount of water, and the temperature is the boiling point of the solvent , the extraction time is 3 hours, precipitated with ethanol, the alcohol precipitation concentration is 80%, filtered, the solvent is recovered, concentrated, fully mixed with auxiliary materials, sterilized, and canned to make a mixture.

Embodiment 3

[0030] (Based on the preparation of 1000ml, the granules are prepared and listed in the form of a table)

[0031]

[0032] Mix the screened Tianshan viola, water lily, chicory, chrysanthemum, rose, senna, and aberle, grind to 24 mesh, extract twice with 10 times the amount of 95% ethanol, and the temperature is 30°C, each extraction time is 1.5 hours, filter, recover the solvent, concentrate, fully mix with excipients, granulate, granulate, and make granules.

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Abstract

The invention relates to a compound medicine for treating a chronic liver disease and a preparing method thereof. The compound medicine is prepared by adding auxiliary materials to seven medicine materials including viola tianschanica maxim., water lily flowers, witloof seeds, humifuse euphorbia herb, roses, folium sennae and cassia fistula to be sufficiently and evenly mixed and conducting solvent extracting, impurity removing, concentrating and drying to prepare mixtures, oral liquid, granules, tablets, capsules or dropping pills. It is shown through an animal experiment result that the medicine can reduce the ALT level and AST level in liver injury model rat serum, reduce liver injury pathological symptoms, and reduce the foot swelling degree of an inflammatory left rear foot. The compound medicine has a certain protection effect on a rat liver injury model. According to the Uygur medical theory, on the basis of long-term famous doctor clinical practice, in combination with modern research, by means of a reasonable extracting method, effective components of the compound medicine are dissolved out, the medicine effect is enhanced, the bioavailability is improved, and convenienceis provided for a patient.

Description

technical field [0001] The invention relates to a compound medicine for treating chronic liver disease and a preparation method thereof, belonging to the technical field of ethnic medicines. Background technique [0002] Chronic liver diseases include chronic hepatitis (mostly chronic viral hepatitis B), post-hepatitis cirrhosis, etc. Clinically, liver inflammation and liver cell necrosis and acute hepatitis (B or C) persist and persist for more than half a year Can become chronic liver disease, is a kind of common disease and frequently-occurring disease. If the chronic liver disease continues to develop, it will often increase the degree of liver damage, which will cause inflammation and necrosis of liver cells, and the pathological process of secondary fibrosis. Liver fibrosis is an intermediate stage in the development of liver cirrhosis and even primary liver cancer. link. According to statistics, there are about 120 million patients with chronic liver disease in my c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K36/86A61P1/16A61P31/14A61P31/20
CPCA61K36/28A61K36/47A61K36/482A61K36/62A61K36/738A61K36/86A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 阿吉艾克拜尔·艾萨艾尼瓦尔·塔力甫祖里皮亚·塔来提
Owner XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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