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Preparation methods of formulated composition for treating vaginitis and externally used preparation thereof

A composition and technology for vaginitis, applied in the field of preparation of formula compositions and external preparations, can solve the problems of long cycle, emphasis on drug efficacy, lack of technical theoretical guidance and the like

Inactive Publication Date: 2012-04-11
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, compared with Western medicine, traditional Chinese medicine lacks technical theoretical guidance for medication, and emphasizes the efficacy of drugs. Traditional Chinese medicine is slow to take effect. It needs to rely on the experience of medical staff to repeatedly select drug formulas and medication methods to treat inflammation, which is costly, inefficient, and long-term. , delay the patient's condition

Method used

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  • Preparation methods of formulated composition for treating vaginitis and externally used preparation thereof
  • Preparation methods of formulated composition for treating vaginitis and externally used preparation thereof
  • Preparation methods of formulated composition for treating vaginitis and externally used preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] This example processes three formula compositions that have analgesic, anti-inflammatory, insecticidal and antipruritic effects, and can be used for trichomonal vaginitis and fungal vaginitis.

[0051] The processing method of the formula composition of analgesia described in this example, anti-inflammation, insecticidal antipruritic effect comprises the following steps:

[0052] a) Preparation of angelica extract: take 3 kg of angelica medicinal material, add ethanol equivalent to 12 times the weight of the medicinal material, that is, 36L, ethanol concentration of 75%, soak for 8 hours, carry out percolation extraction, control the flow rate to 2mL / min, and concentrate the extract Angelica sinensis extract was obtained, the concentration ratio of the angelica sinensis extract was 6, and the concentration temperature of the extract was 50° C.; 2.15 kg of the angelica sinensis extract was obtained after spray drying, and the content of ferulic acid in the angelica sinens...

Embodiment 2

[0059] This example prepares a vaginal suppository of formula composition for treating vaginitis.

[0060] Preparation steps of a vaginal suppository of a formula composition for treating vaginitis described in this example: Weigh 50 parts of the pre-mixed formula composition, totaling 500 g, add an appropriate amount of water to fully stir and disperse to prepare the active ingredient suspension. 50 parts of mixed base (polyethylene glycol 4000: polyethylene glycol 6000 (4: 2)), 500 g in total, melted at 65 ° C, added the above suspension into the molten mixed base, poured into the mold, cooled, and eliminated overflow part, made 200 purplish red suppositories.

Embodiment 3

[0062] This example processes an external lotion of a formula composition for treating vaginitis.

[0063] The preparation steps of an external lotion of a formula composition for the treatment of vaginitis described in this example: take 1 part of the formula composition mixed in advance, 10g in total, 0.5 part of borneol, 5g in total, add in 99 parts of bitter wine, total Volume 100ml, 100Hz ultrasonic wave for 30 minutes, ultrafiltration membrane filtration, bottled to obtain a lotion for external use with good appearance and color.

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Abstract

The invention provides preparation methods of a formulated composition and an externally used preparation thereof with the effects on alleviating pain, diminishing inflammation, destroying parasites and relieving itching for treating trichomonal vaginitis and colpomycosis. The formulated composition and externally used preparation thereof comprise the following components in contents: 20-95% of angelica sinensis extract, 1-10% of gromwell extract and 3-30% of sophora alopecuroide extract. Shown by a mouse hot plate method, a torsion pain experiment, a mouse ear swelling method caused by xylene, a rat toe swelling experiment and an anti-mildew experiment, both the composition and the externally used preparation have notable analgesic, antiphlogistic and antibacterial actions. The formulated composition and the externally used preparation provided by the invention adopt traditional Chinese medicinal materials as raw materials, have no toxic and side effects and can be used for a long term; especially, the preparation methods of externally used suppository, lotion and effervescing agent provided by the invention have simple processes and are favorable for industrialized production; the externally used preparation not only plays a local therapeutic action, but also can play a systemic therapeutic action; and shown by clinical tests, the formulated composition and the externally used preparation provided by the invention have the efficacies of alleviating pain, diminishing inflammation, destroying parasites and relieving itching, and can be used for effectively treating vaginitis.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a formulation composition for treating vaginitis and a preparation method for external preparations, wherein the external preparations include suppositories, lotions and effervescent suppositories. Background technique [0002] Gynecological inflammation is one of the common diseases of women, mainly including vaginitis, cervicitis, adnexitis and pelvic inflammatory disease, which belongs to the category of "leukorrhagia" in theory in traditional Chinese medicine. Gynecological inflammation tends to recur easily, persist for a long time, and even lead to the occurrence of other malignant diseases, seriously damaging women's health. Therefore, great attention should be paid to gynecological inflammation, and it is necessary to take scientific treatment measures. The effect of traditional treatment of gynecological diseases is unsatisfactory. Western medicine sterilize...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/489A61K9/02A61P15/02
Inventor 胡芳弟苟于强杨雪梅
Owner LANZHOU UNIVERSITY
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