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120results about How to "Improve inflammatory response" patented technology

Processes for removing cells and cell debris from tissue and tissue constructs used in transplantation and tissue reconstruction

Methods for decellularizing mammalian tissue for use in transplantation and tissue engineering. The invention includes methods for simultaneous application of an ionic detergent and a nonionic detergent for a long time period, which may exceed five days. One method utilizes SDS as the ionic detergent and Triton-X 100 as the nonionic detergent. A long rinse step follows, which may also exceed five days in length. This long duration, simultaneous extraction with two detergents produced tissue showing stress-strain curves and DSC data similar to that of fresh, unprocessed tissue. The processed tissue is largely devoid of cells, has the underlying structure essentially intact, and also shows a significantly improved inflammatory response relative to fresh tissue, even without glutaraldehyde fixation. Significantly reduced in situ calcification has also been demonstrated relative to glutaraldehyde fixed tissue. Applicants believe the ionic and non-ionic detergents may act synergistically to bind protein to the ionic detergent and may remove an ionic detergent-protein complex from the tissue using the non-ionic detergent. The present methods find one exemplary use in decellularizing porcine heart valve leaflet and wall tissue for use in transplantation.
Owner:UEDA YUICHIRO +1

Composition comprising a carrier and a purified mycobacterial lipid cell-wall component and its use in the treatment and diagnosis of disease

A composition including a purified lipid cell-wall component or analog or derivative thereof and a suitable pharmaceutical carrier, medium, excipient or adjuvant is described. The composition is useful in prophylactic and therapeutic methods of treating a microbial infection in a subject, typically a mycobacterial infection such as tuberculosis, and immune disorders, inflammatory conditions and allergies in a subject, typically autoimmune diseases. It is also useful in diagnostic methods. The purified lipid cell-wall component is typically a purified mycolic acid or a mixture of purified mycolic acids from a bacterium which produces mycolic acids. The bacterium is from Mycobacterium, Corynebacterium, Nicardia or Rhodococcus.
Owner:ADCOCK INGRAM LTD

Magnesium alloy support coated with acylated chitosan and polyester blend medicine coating

InactiveCN102488932AControlled bioabsorption and degradation propertiesHigh specific strengthStentsCoatingsPolyesterThrombus
The invention provides a magnesium alloy support coated with an acylated chitosan and polyester blend medicine coating. The support comprises a magnesium alloy bare support, the magnesium alloy bare support comprises at least two annular units formed by cylindrical rods in a sine 'peak-valley' shape, the annular units are connected on the axial direction through a link round rod to form a net structure, a blend medicine eluting type coating composed of acylated chitosan, polyester and medicine is coated on the surface of the magnesium alloy bare support. According to the invention, biological medical chitosan and polyester blend material are taken as a support surface coating to improve the biological compatibility, and the coating carries a medicine with restenosis resistance function, thereby the release speed of the medicine can be controlled, and the treatment purpose can be achieved. The magnesium alloy support coated with the acylated chitosan and polyester blend medicine coating possesses good collateral passing ability and flexibility, good radial supporting performance, and is capable of keeping perfusion smoothness of blood flow, effectively delaying the degradation time of the magnesium alloy support, controlling the release of the medicines, and reducing the incidence rate of acute and subacute thrombus after the support is implanted.
Owner:HARBIN ENG UNIV

Recyclable heart stent

The invention provides a recyclable heart stent. The recyclable heart stent comprises a transmission assembly, an elastic mesh bag and a heating device, the transmission assembly comprises a catheterand a gasbag, the gasbag is fixedly arranged at one end of the catheter, the gasbag is sleeved with the elastic mesh bag, and the elastic mesh bag is made of a plurality of elastic tubes connected toeach other; the elastic tubes are filled with liquid metals, the heating device is used to heat the liquid metals in the elastic tubes, and in the recyclable heart stent, the elastic mesh bag confinesthe liquid metal to form a stent body; at the time of implantation, the structure of the elastic mesh bag is changed by inflating the gasbag, and the liquid metals are solidified so that the stent body maintains a specific shape structure; and at the time of recycling, the liquid metals are melt, the structure of the stent body is reduced by the inflating and the deflating of the gasbag and the elasticity of the elastic mesh bag, and then the stent body is brought out of the human bodies through the catheter. In addition, the liquid metals have the advantages of good bio-compatibility, anti-thrombus and anti-corrosion, and the liquid metals have no damage to the blood vessel wall so that the stimulation of blood vessels to cause the inflammatory reaction is avoided.
Owner:YUNAN JINGCHUANG LIQUID METAL THERMAL CONTROL TECH RES & DEV CO LTD

Acne-removing essence for external use for treating facial acne and preparation method and applications thereof

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to acne-removing essence for external use for treating facial acne and a preparation method andapplications thereof. The essence includes: 10-30 parts by weight of milk-vetch roots, 10-30 parts by weight of baical skullcap roots, 10-30 parts by weight of golden thread, 10-30 parts by weight ofamur cork-tree, 10-30 parts by weight of rhubarb roots, 10-30 parts by weight of Chinese angelica, 10-30 parts by weight of garden burnet root, 10-30 parts by weight of rehmannia root, 10-30 parts byweight of dahurian angelica roots, 10-30 parts by weight of blackend swallowwort roots, 10-30 parts by weight of common bletilla rubber, 10-30 parts by weight of frankincense, 10-30 parts by weight of myrrh, 3-8 parts by weight of borneol, 800-1000 parts by weight of sesame oil and 200-500 parts by weight of vaseline. The above components are heated and mixed in batches to prepare the acne-removing essence. The comparison of 4 patients with acne before using the acne-removing essence and after using the acne-removing essence indicates that the acne-removing essence of the invention can effectively inhibit facial inflammatory reaction, has the effect of reducing the number of inflammatory papules, reducing cystic nodules and removing phlegm cysts, and the total effective rate of acne treatment with the acne-removing essence for external use in 4 acne patients reaches 100%.
Owner:唐和斌

Application of polypeptide in preparation of drugs for treatment and/or prevention of rheumatoid arthritis

The invention discloses an application of a polypeptide or polypeptide derivatives capable of specific combination of TRB3 in preparation of drugs for treatment and / or prevention of rheumatoid arthritis; the polypeptide has the amino acid sequence being any one of sequences shown in SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:3; the polypeptide derivatives are chimeric peptides formed by connecting the polypeptide with cell membrane cell-penetrating peptides. The polypeptide or the polypeptide derivatives can be specifically combined with the TRB3 so as to block the interaction between the TRB3 and P62 proteins; and the peptide fragment derivatives Pep2-A1, Pep2-A2 and Pep2-A3 can treat or prevent various symptoms caused by rheumatoid arthritis.
Owner:胡卓伟

Application of konjac flour to treatment and improvement of obesity

Relating to the field of health, the invention relates to application of konjac flour to treatment and improvement of obesity. The invention consists of the following aspects: konjac flour intervenedanti-obesity effect; the influence of konjac flour intervention on inflammation; the regulating effect of konjac flour intervention on intestinal microorganisms; the influence of konjac flour intervention on colonic intestinal barrier function; the influence of konjac flour intervention on energy metabolism; and the correlation of konjac flour to intestinal microorganisms and obesity. The invention has the beneficial effects that: konjac flour not only can improve obesity-related indicators, but also can increase the diversity of intestinal microorganisms and improve the microbial community structure, promote the formation of beneficial bacteria and inhibit the growth of obesity-promoting bacteria.
Owner:KUNMING UNIV OF SCI & TECH

Oral skin regeneration promoting oil for treating oral cavity burn and scald and preparation method and application thereof

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to an oral skin regeneration promoting oil for treating oral cavity burn and scald and a preparation method and application thereof. The oral skin regeneration promoting oil is prepared from, by weight, 10-30 parts of scutellaria baicalensis, 10-30 parts of coptis chinensis, 10-30 parts of amurcork tree bark, 10-30 parts of Chinese rhubarb, 10-30 parts of astragali radix, 10-30 parts of angelica sinensis, 10-30 parts of garden burnet, 10-30 parts of rehmannia glutinosa, 10-30 parts of angelica dahurica,10-30 parts of blackend swallowwort root, 10-30 parts of bletilla striata, 10-30 parts of frankincense, 10-30 parts of myrrh, 3-8 parts of borneol and 1000-1500 parts of edible vegetableoil, wherein the skin regeneration promoting oil is prepared by heating and mixing the materials in batches. Staining results show that the inflammatory cell infiltration of wound tissues of oral cavity burn and scald site of a rat group using the skin regeneration promoting oil is obviously reduced, the tissue structure is relatively complete, the skin regeneration promoting oil has the effectsof treating oral cavity burn and scald caused by boiling water, acid and alkali. The oral toxicity experiment of the skin regeneration promoting oil show that there is no significant difference in body weight, liver and kidney function of rats compared with a blank group, and no obvious influence is produced.
Owner:深圳市本源生物科技有限公司
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