35results about How to "Good tumor growth" patented technology

The invention discloses microencapsulated human pancreatic carcinoma cells, and a preparation method and application thereof. The preparation method comprises the following steps of: adding suspension with human pancreatic carcinoma cells into Matrigel-containing sodium alginate solution; spraying into a calcium chloride solution in high voltage electrostatic environment to obtain microspheres; and performing ion exchange reaction on the microspheres and a sodium citrate solution, and thus obtaining the microencapsulated human pancreatic carcinoma cells. The obtained microencapsulated human pancreatic carcinoma cells have uniform size and the diameter of about 420mm. Cells in microcapsules are well proliferated, and grow in a three-dimensional way. The microencapsulated human pancreatic carcinoma cells are applied to subcutaneous tumor and in-situ tumor animal models, and have the advantages of high modeling success rate and quick tumor growth compared with the traditional tumor cell suspension injection method.

The present inventors used a model of intrasplenically induced liver metastasis to determine whether or not NF-κB activation in the liver is involved in the onset of metastatic tumors. When IKKβ was deleted from both liver cells and hematopoietically-derived cells, the onset of tumors was reduced remarkably. Tumor cells activated neighboring bone marrow cells (Kupffer cells) and produced mitogens such as interleukin (IL)-6, and this promoted angiogenesis and growth of tumors. The mitogen production depended on NF-κB in hematopoietically-derived Kupffer cells. Furthermore, treatment with an anti-IL-6 receptor antibody decreased the degree of metastatic tumor development. That is, the present inventors showed that tumor metastasis depends on inflammation, and proinflammatory intervention that targets Kupffer cells is useful for chemical prevention of metastatic tumors. Furthermore, it was shown that inhibition of the IKKβ / NF-κB signal transduction pathway, in particular IL-6 inhibition, can be utilized for anti-metastasis agents.

The present invention relates to novel nucleic acids encoding novel amino acid fragments of polypeptides, called abrogens. The present invention also relates to novel, potent in vitro and in vivo inhibitors of endothelial cell proliferation, and compositions of them and their use. The present invention further provides methods for modulating angiogenesis and / or inhibiting unwanted angiogenesis. Polypeptides according to the present invention are useful for developing cell growth-modulating compositions and methods and for treating and / or preventing cancer, tumor growth, or other angiogenic dependent or angiogenesis associated diseases.

The current invention provides monocytic cells transfected with chimeric antigen receptor (CAR) to selectively home to tumors and upon homing differentiate into dendritic cells capable of activating immunity which is inhibitory to said tumor. In one embodiment of the invention, monocytic cells are transfected with a construct encoding an antigen binding domain, a transcellular or structural domain, and an intracellular signaling domain. In one specific aspect of the invention, the antigen binding domain interacts with sufficient affinity to a tumor antigen, capable of triggering said intracellular domain to induce an activation signal to induce monocyte differentiation into DC.

The invention relates to multifunctional microbubbles integrating ultrasonic imaging and chemotherapy, and relates to a preparation method of the multifunctional microbubbles and application of the multifunctional microbbles to tumor diagnosis and treatment. The structure diagram integrating ultrasonic imaging and chemotherapy is shown in the figures, the membrane components of the microbubbles comprise Janus drug conjugates used for chemotherapy and conventional phosphatides, the proportions of the Janus drug conjugates and the conventional phosphatides can be regulated according to needs, and therefore the drug loading capacity is greatly improved. Under an ultrasonic effect, the purpose that designated targeted blasting is converted to nano particles at a tumor site can be achieved through the multifunctional microbubbles, so that the enrichment and uptake of drugs at the tumor site are greatly improved, and the effect of suppressing tumor growth through chemotherapy is greatly improved.

The present invention relates generally to structural studies of the insulin binding site of the insulin receptor (IR) and the insulin-like growth factor 1 receptor (IGF-1R). More particularly, the present invention relates to the crystal structure of the low affinity insulin binding site of the IR ectodomain comprising the C-terminal region of the IRα-chain, as well as the corresponding region of IGF-1R, and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the function of IR and / or IGF-1R.

This invention provides a method for treating cancer in mammals through cellular-organelle-crystallization-induced-death (herein defined as “Cocid”), a method for treating cancer using cellular organelle and / or cytoskeleton crystallizing agents (e.g. tetrazolium salts and their derivatives), pharmaceutical compositions containing a therapeutically effective amount of organelle and / or cytoskeleton crystallizing agents, and compositions containing organelle and / or cytoskeleton crystallizing agents in combination with a pharmaceutically acceptable carrier, diluent or excipient. The crystallizing agents with or without a pharmaceutically acceptable carrier, diluent or excipient, are used in combination with surgery and / or non-surgical anti-tumor treatments.

The invention relates to a supercritical extract of pigeon pea leaves and the new application of the main component of the extract ---pigeon pea stilbene acid (containing pigeon pea stilbene acids I-VI) in antitumor aspect. After different excipients are added to the pigeon pea stilbene acid, the pigeon pea stilbene acid can be processed into any pharmaceutical dosage form. The supercritical extract of pigeon pea leaves and pigeon pea stilbene acid (containing pigeon pea stilbene acid I-VI) has the characteristics of light toxic and side effect, accurate curative effect, safety, reliability, and the like. Pigeon peas have the advantages of abundant resources, convenient collection, simple extraction process and convenience for industrial production.

The present invention relates generally to structural studies of the insulin binding site of the insulin receptor (IR) and the insulin-like growth factor 1 receptor (IGF-1R). More particularly, the present invention relates to the crystal structure of the low affinity insulin binding site of the IR ectodomain comprising the C-terminal region of the IR α-chain, as well as the corresponding region of IGF-1R, and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the function of IR and / or IGF-1R.

Disclosed is a method for delivering a gene into target cells, wherein immune cells are used as a vector for virus packaging and transportation to complete the delivery of biomacromolecules among cells, and thus change original characteristics of the target cells or generate new characteristics in the target cells. The gene delivery system, on one hand, can kill target cells such as tumor cells by utilizing the specificity of immune cells; and on the other hand, can modify genes of cells in a lesion by gene delivery to target cells, to directly kill the target cells.

The present invention relates to novel markers for alternatively activated macrophages. More specifically, the present invention relates to the use of galactose-type C-type lectins as surface markers that allows rapid identification and sorting of the alternative macrophages. Such identifications can be useful in diseases where there is an imbalance between proinflammatory and anti-inflammatory immune reactions.

The invention relates to a traditional Chinese medicine preparation for treating leukemia and relieving side effects of chemotherapy. The traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight: 200 parts of cistanche, 200 parts of Chinese Starjasmine Stem, 100 parts of cordate houttuynia, 50 parts of manyleaf paris rhizome, 15 parts of Oldenlandia diffusa, 15 parts of Sculellaria barbata and 5 parts of ginseng. The traditional Chinese medicine preparation disclosed by the invention is simple and convenient to prepare, is wide in drug source and low in cost and has a wide application prospect.