The invention relates to the bedding field, and especially relates to a warp knitted spacer fabric mattress and a making method thereof. The mattress comprises an adjustable mattress inner liner and a stereo mattress sleeve, the mattress sleeve is obtained by sewing an upper surface layer, a lower surface layer and a side wall, and at least the upper surface layer and the side wall are warp knitted spacer fabrics; and the mattress inner liner is adjustable and comprises at least two independent inner liner bodies with different supporting strengths arranged in the mattress sleeve, each of the inner liner bodies has a multilayer structure, and at least the top layer is a wrap knitted spacer fabric, so the inner liner bodies and all the layers for forming the inner liner bodies can be reasonably combined and arranged according to ergonomic requirements to adapt to requirements of parameters of the supporting of different positions of a human body, different heights, different body weights and the like. The application of the warp knitted spacer fabric to the mattress sleeve in the invention makes the mattress sleeve have the advantages of elasticity, permeability, ergonomic conforming, bacterial growing inhibition and the like of the warp knitted spacer fabric and simultaneously have the characteristics of dismounting and mounting convenience and cleaning convenience of the mattress sleeve.