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Photosensitizer having dual photodynamic therapy effects and preparation method thereof

A technology of photodynamic therapy and photosensitizer, which is applied in the field of photosensitizer and its preparation, can solve the problems of excessive oxygen consumption, poor photostability, poor water solubility, etc., and achieve the effect of easy-to-obtain raw materials, mild synthesis conditions and good photostability

Active Publication Date: 2017-04-26
合肥欧申福德生物科技有限责任公司
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Problems solved by technology

However, the currently used photosensitizers generally have disadvantages such as poor water solubility, poor photostability, high energy excitation, and excessive oxygen consumption.

Method used

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  • Photosensitizer having dual photodynamic therapy effects and preparation method thereof
  • Photosensitizer having dual photodynamic therapy effects and preparation method thereof
  • Photosensitizer having dual photodynamic therapy effects and preparation method thereof

Examples

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Embodiment Construction

[0037] The preparation method of the photosensitizer with double photodynamic therapy effect in this embodiment is as follows:

[0038] 1. Add 100mL of a mixed solution of ethylene glycol monomethyl ether and water (V / V=3:1), 0.71g of IrCl to a 250mL round bottom flask in sequence 3 ·3H 2 O (2.0mmol) and 0.68g (4.4mmol) phenylpyridine were heated to 120°C for reflux reaction for 24h. After the reaction was completed and cooled to room temperature, a yellow solid precipitated, filtered with suction, and the filter residue was washed with 30mL water and 30mL ethanol for two times respectively. times, a yellow powder (BP) was obtained after vacuum drying 4 Ir 2 Cl 2 .

[0039] 2. Add 0.21g (0.2mmol) (BP) to the 150mL Shrek bottle successively 4 Ir 2 Cl 2 , 0.17g (0.5mmol) ETP and a mixed solution of 50mL dichloromethane and methanol (V / V=1:1), reflux reaction at 60°C for 24h under the protection of nitrogen, cool to room temperature after the reaction, add 0.31g of NH 4 ...

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Abstract

The invention discloses a photosensitizer having dual photodynamic therapy effects and a preparation method thereof, wherein the photosensitizer having the dual photodynamic therapy effects has the structural formula described in the specification. With cheap and easy-to-obtain 2-phenylpyridine, iridium trichloride and ethyl benzoate terpyridine as raw materials, and through mild reaction conditions, a target product-iridium complex is simply and efficiently synthesized. Research results indicate that the iridium complex has two-photon excited fluorescence emission in a near infrared region and can be used as a photosensitizer for photodynamic therapy. Confocal development is used for tracking the photodynamic therapy process, the photosensitizer iridium complex can be obviously observed to migrate from cell nucleuses to mitochondria under illumination, and secondary damage of the cells is caused. Animal experiments also prove that the iridium complex has quite good inhibitory effects on tumor growth under a near infrared irradiation condition and has low toxicity to animal bodies in dark environments.

Description

technical field [0001] The invention relates to a photosensitizer and a preparation method thereof, in particular to a photosensitizer with dual photodynamic therapy effects and a preparation method thereof. Background technique [0002] In recent decades, photodynamic therapy has attracted more and more attention. So far, photodynamic therapy has been successfully applied in the treatment of many diseases, such as: lung cancer, bladder cancer, ophthalmic cancer and urinary system tumors. Photodynamic therapy is a new technology that uses photodynamic response to treat tumors. The basis of photodynamic therapy is the photodynamic effect, which is a photosensitization reaction accompanied by biological effects involving oxygen molecules. Under the condition of light, the photosensitizer absorbs photons and transitions from the ground state to the excited state, and the molecules in the excited state transfer energy to the triplet oxygen during the falling process, convertin...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61P35/00
CPCA61K41/0057
Inventor 田肖和祝英忠张明珠吴杰颖田玉鹏周虹屏杨家祥李胜利
Owner 合肥欧申福德生物科技有限责任公司
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