184results about How to "Improve obesity" patented technology

The present invention provides a compound represented by general formula (I): or pharmaceutically acceptable salts thereof, wherein W is O, S(O)m, CH2 and the like; R1 is halogen, lower alkyl, halo-lower alkyl, CN and the like; R3 is hydrogen and the like; R4 is hydrogen, halogen, alkyl, halo-lower alkyl, substituted alkyl, aryl, aralkyl, alkoxy, substituted alkoxy, alkanoyl, aroyl, —CONR7(R8), —S(O)mR9, —SO2NR7(R8) and the like; R5 is hydrogen, halogen, alkyl, substituted alkyl and the like; A is —N(R6)CO-A1-COR10 and the like; pharmaceutical compositions containing them and their uses, which have a high affinity to human thyroid hormone receptors, in particular human thyroid hormone receptor β.

This invention relates to a nutritional formulation comprising an n3 long-chain polyunsaturated fatty acid (LC-PUFA), a prebiotic fibre and a probiotic bacterial strain which ingredients act together in a synergistic fashion to promote catch-up growth in young mammals whose growth has been retarded because the young mammal has been subjected to physical or mental stress.

The invention provides a new function of a compound-pyrocincholic acid 3beta-O-beta-D-quinovopyranosyl-28-O-beta-D-glucopyranoside (PAQG), extracted from metadina trichotoma, in adjustment and control of lipid metabolism in 3T3-L1 cells, and application of the compound in preparation of medicines, food and health care products which are used for relieving obesity and obesity-related metabolic diseases. The PAQG inhibits the differentiation of the 3T3-L1 preadipocytes by activating adenosine monophosphate-activated protein kinase (AMPK), and down-regulates the expression of differentiation-related transcription factors and proteins (PPAR gamma, C / EBP beta, C / EBP alpha and FABP4) and the release of adiponectin. Furthermore, the PAQG inhibits the fat accumulation in the 3T3-L1 mature adipocytes by inhibiting fatty acid synthesis and promoting lipid oxidation. The PAQG relieves the obesity from both fat cell number and fat content under the premise of safe and effective dosage of administration, thus being used for the preparation of medicines, health care products and functional food which are used for preventing and treating the obesity and the obesity-related metabolic diseases.

The invention relates to a special clinical nutritional formula for simple obesity of a child. The special clinical nutritional formula comprises the following components in parts by weight: protein, fat, carbohydrate, water-soluble dietary fiber, macroelement, trace element, fat-soluble vitamin, water-soluble vitamin, dietary essence, medicinal and edible component, natural plant compound and new resource food. The invention also relates to a preparation method of the clinical nutrition formula. The preparation method comprises the following steps of: preparing all the components into powder in advance, adopting alcohol-extracting and water-extracting concentration for the medicinal and edible component, spraying and drying into powder, or preparing the vitamins and the fat into powder by microencapsulation treatment; or carrying out emulsification and homogenization on all the components by a wet process, spraying and drying into powder. The special clinical nutritional formula provides comprehensive and full nutritional support for the simple obesity of the child so as to improve the body condition of the child patient with the simple obesity and play a role in improving the spleen-stomach capacity of the child, reducing the body weight and enhancing the constitution.

The present invention relates to a novel exenatide analogue, which is an exenatide analogue in which the first to fifteenth amino acids from the C-terminal of the amino acid sequence of exenatide are deleted and a fatty acid is conjugated. The present invention provides a short length exenatide exhibiting almost the same level of anti-diabetic effects compared with that of conventional exenatide and liraglutide, which is an anti-diabetic drug, and capable of reducing the preparation cost of exenatide.

The invention relates to a special nutrition pot for a Gobi desert, a preparation method and an application thereof. The special nutrition pot for the Gobi desert is prepared from the following raw materials in percentages by weight: 55-65% of sludge and agricultural waste fermentation nutrient matrix, 25-30% of bentonite, 5-10% of attapulgite, 3.5-4% of biochar, 0.7-1.2% of a biodegradable flocculant and 0.3-0.5% of a physical light mixture. On one hand, the environmental protection problem of harmless resource utilization of production and life sludge wastes and agricultural wastes is solved; and on the other hand, organic matters in the sludge wastes and agricultural wastes can be effectively utilized, the finally produced special nutrition pot for the Gobi desert has the effects of environmental biodegradablity, high-oxygen humus, heat retention property and low temperature resistance, moisture adsorption, water storage and retention, drought avoidance, root protection, slow release of nutrients, land fertilization and soil improvement, and is suitable form massive industrial seedling of tree seedlings; use of a lot of plastic containers is reduced; the roots are not damaged in transplantation; and the special nutrition pot is especially suitable for popularization in alpine regions, water-deficient areas and serious soil desertification areas.

The invention discloses a composition having efficacy of reducing weight. Through guidance under a traditional Chinese medicine theory, a formula consisting of medicinal and edible traditional Chinesemedicines, high-function fruits and vegetables and natural ingredients is adopted, a medicinal and edible traditional Chinese medicine compound recipe is used for wholly and systematically conditioning bodies and improving obesity constitutions, the high-function fruits and vegetables and the natural ingredients can quickly supplement fat metabolism accelerating factors, satiety factors and intestinal tract prebiotics for organisms, the medicinal and edible traditional Chinese medicines, the high-function fruits and vegetables and the natural ingredients are in organic collocation for whollyconditioning the organisms and treating both manifestation and root causes of diseases, the composition is safe, free from addiction and high in speed of taking effects, achieves the purposes of elevating clear Qi to lower turbid Qi, eliminating phlegm, humidity and blood stasis, removing fat, invigorating pulse and enabling internal organs to be smooth, and achieves the efficacy of reducing weight. The composition consists of natural food ingredients, is free from dependence, free from toxic and side effects and high in safety. Besides, the composition has good mouth feel, anorexia cannot becaused, the mouth feel of foods can be adjusted, the composition can be made into foods of beverages, biscuits, pastries, sweets and the like, the efficacy of reducing weight can be realized, and thecomposition is convenient to carry and eat.

Relating to the field of health, the invention relates to application of konjac flour to treatment and improvement of obesity. The invention consists of the following aspects: konjac flour intervenedanti-obesity effect; the influence of konjac flour intervention on inflammation; the regulating effect of konjac flour intervention on intestinal microorganisms; the influence of konjac flour intervention on colonic intestinal barrier function; the influence of konjac flour intervention on energy metabolism; and the correlation of konjac flour to intestinal microorganisms and obesity. The invention has the beneficial effects that: konjac flour not only can improve obesity-related indicators, but also can increase the diversity of intestinal microorganisms and improve the microbial community structure, promote the formation of beneficial bacteria and inhibit the growth of obesity-promoting bacteria.

The invention discloses an immunity-enhancing health nutritional composition, as well as a preparation method and application thereof. The immunity-enhancing health nutritional composition comprises the following raw materials by weight: 20 to 40 parts of sprouted highland barley flour, 5 to 15 parts of oat meal, 10 to 30 parts of milk powder, 1 to 5 parts of yak bone meal, 5 to 15 parts of duck wheat, 0.1 to 1 part of ginseng powder, 2 to 8 parts of fructo-oligosaccharide, 5 to 15 parts of yam powder, 1 to 10 parts of golden silk jujube powder, 0.1 to 1 parts of haematococcus pluvialis, and 0.1 to 1 part of fructus momordicae powder. The immunity-enhancing health nutritional composition can have an immunity-enhancing efficacy according to the requirements of modern consumers, and has the advantages that the raw materials are natural; no side effect is caused; the suitability for the middle-aged and elderly as well as crowds of which the immunities are required to be enhanced is very high; the taste is good. Therefore, the immunity-enhancing health nutritional composition achieves popularity.

The invention discloses a probiotics composition with a fat reducing function and a preparation method and application thereof. The probiotics composition is prepared from the following components in percentage by mass: 50 to 60 percent of dry probiotics powder, 5 to 10 percent of honeysuckle extract powder, 5 to 10 percent of sweet wormwood extract powder, 10 to 15 percent of astragalus membranaceus extract powder, 10 to 15 percent of radix puerariae extract powder, and 10 to 15 percent of radix scutellariae extreact powder. Beneficial bacteria and traditional Chinese medicines are two types of internationally recognized probiotics, and the working mechanisms are interlinked; in a specific use process, the beneficial bacteria and the traditional Chinese medicines can perfectly supplement each other to exert the advantages together. According to the probiotics composition with the fat reducing function, the beneficial bacteria and the traditional Chinese medicines are perfectly combined; due to the bacteria increasing effect of the traditional Chinese medicines, propagation of the probiotics is promoted, and the microecological balance in intestines can be adjusted. Such probiotics as bifidobacterium, lactobacillus plantarum and lactobacillus acidophilus can produce nutritional substances such as conjugated linoleic acid which can affect fat metabolism, so that the effect of reducing the fat can be achieved.