321results about How to "Same effect" patented technology

The invention provides methods, systems and reagents for regulating pH-sensitive protein interaction by incorporating non-natural amino acids into the protein (e.g. an antibody, or its functional fragment, derivative, etc.). The invention also relates to specific uses in regulating pH-sensitive binding of antibodies to tumor site, by conferring enhanced tumor-specificity/selectivity. In that embodiment, the non-natural amino acids preferably have desirable side-chain pKa's, such that at below physiological pH (e.g. about pH 6.3-6.5) the non-natural amino acid confer enhanced binding to tumor antigens in acidic environments. Such non-natural amino acids can be incorporated by any suitable means, such as by utilizing a modified aminoacyl-tRNA synthetase to charge the nonstandard amino acid to a modified tRNA, which forms strict Watson-Crick base-pairing with a codon that normally forms wobble base-pairing with natural tRNAs (e.g. the degenerate codon orthogonal system.

A method for producing a chewing gum with a controlled release active agent, as well as the chewing gum so produced, is obtained by physically modifying the release properties of the active agent, such as a nutraceutical or nutritional supplement, by coating and drying. The active agent is coated by encapsulation, partially coated by agglomeration, entrapped by absorption, or treated by multiple steps of encapsulation, agglomeration, and absorption. The coated active agent is preferably then co-dried and particle sized to produce a release-modified active agent for use in chewing gum. The active agent may also be used in a coating on a chewing gum product, as part of a rolling compound applied to the chewing gum product, or as a part of the liquid in a liquid-center chewing gum product.

A computerized system for preventing host intrusions on a communication device. The device is wirelessly connected to a wireless communication network. The system includes a computer readable management software module configured to analyze malicious payloads. The management software module includes an asset manager module configured to assign updates to the communication device, a device database module configured to describe the communication device characteristics and a build database module configured to automate software builds of the communication device core operating system. The management software module also includes a component builder module configured to run a plurality of instruction sets to establish a build environment for the communication device according to the communication device characteristics, a configuration manager module configured to build the instruction sets and an operating system product module configured by the build database module as part of a build process triggered by the asset manager module.

Game machines automatically change the difficulty level of the game operation in the middle of the game based on an evaluation made on a player's game operation. A game machine determines, at least in terms of timing and type, whether the player's inputted button operation matches with the button operation designated by the game. If there is a match, the game machine determines it as an operation success. If not, the game machine determines it as an operation error. Based on the degree of operation success or operation error, the game machine dynamically changes the difficulty level of the game operation in the middle of the game.

A video output device which converts image data into a YUV system video signal composed of a brightness signal Y and a chrominance signal UV and outputs the video signal obtained by the conversion through a predetermined interface is disclosed. The video output device includes: a mantissa part converting unit which, with respect to first image data composed of pixel data in which a pixel value is expressed by a floating point format in which a mantissa part has N bits (N is a natural number of 2 or more), a cardinal number is X (X is a natural number of 2 or more) and an exponential part has M bits (M is a natural number of 2 or more), converts mantissa part data of the pixel data configuring the first image data into the YUV system video signal; a multiplexing unit which multiplexes exponential part data of the pixel data configuring the first image data to the chrominance signal UV of the YUV system video signal; and a video signal output unit which outputs the YUV system video signal including the brightness signal Y and the chrominance signal UV obtained by multiplexing the exponential part data.

An image processing apparatus is an apparatus for determining a gaze from a motion picture of a face taken by a monocular camera, and is configured to define a 3D structure of a center of a pupil on the facial picture by a static parameter and a dynamic parameter, and to determine the gaze by estimating the static parameter and the dynamic parameter. Another image processing apparatus is an apparatus for determining a motion of a 3D object from a motion picture thereof taken by a monocular camera, and is configured to define a 3D structure of the 3D object on the picture by a rigid parameter and a non-rigid parameter, and to determine the motion of the 3D object by estimating the rigid parameter and the non-rigid parameter.

A studded membrane is proposed for the protection of buildings with a drainage and slip surface formed on the reverse side thereof. This ensures that water is drained

• • between the studded membrane and the exterior surface of the building,
  • between the studded membrane and the seal,
  • between the studded membrane and the insulation.

A medium discharging device includes a discharging unit which discharges a medium; and a medium receiving tray which receives the medium discharged by the discharging unit, and is switched between an extended state and an accommodated state, in which the medium receiving tray is provided with a base tray, a main extendeding unit that is accommodated or extended, and at least one sub-extendeding unit that is accommodated or extended, and in which the base tray forms an accommodating space for accommodating at least the one sub-extendeding unit, and is provided with a first protrusion portion protruding toward the accommodating space.

A magnetic encoder for use in a vehicle axle for generating pulse code by magnetic force. A magnetic ring is attached with an adhesive to a reinforcing ring fixed on the vehicle axle and then S and N poles are alternately magnetized thereon in a circumferential manner. Further the edge of the reinforcing ring is folded to fix the magnetic ring by caulking into the reinforcing ring.

A dynamic or aerodynamic fin comprising at least two parallel arranged fin sections. At least one fin section comprises a rotational axis for installing the fin section by a rotation shaft. An end stop is provided for stopping the rotational movement of the fin section to define an extreme position. In the extreme position the fin sections provide a substantially cambered shape to the fin. The dynamic fin is improved in that it comprises a pair of coupling elements. A first fin section is coupled to a second adjacent fin section by a pair of a first and second coupling elements. The first coupling element is complementary to the second coupling element. The first coupling element is part of, preferably integral, with the first fin section and the second coupling element is part of, preferably integral, with the second fin section.