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Plant extract, and preparation method and application thereof

A technology of plant extracts and medicines, applied in the direction of food ingredients, applications, and plant raw materials containing natural extracts, can solve the problems of side effects and limited types, and achieve the effects of lowering blood lipids, improving inflammatory reactions, and having no toxic side effects

Inactive Publication Date: 2017-06-06
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing types of drugs with the above effects are limited, and some of them have side effects, so it is necessary to further expand the optional types of drugs

Method used

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  • Plant extract, and preparation method and application thereof
  • Plant extract, and preparation method and application thereof
  • Plant extract, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Such as figure 1 As shown, using 0.5kg cloth dregs leaves and 0.5kg guava leaves as raw materials, the active extract parts are obtained after extraction, separation and purification. The extraction solvent is 70% ethanol, the ratio of solid to liquid is 1:20, and heated to reflux at 90°C; the crude extract is concentrated under reduced pressure until the alcohol is light, centrifuged at 3000r / min for 20min at room temperature, and the supernatant is added with 4 times the volume of purified water and then used in 1000g Macroporous resin adsorbed overnight; then eluted with 10%, 70%, 100% methanol solution, collected 70% methanol eluted part, concentrated under reduced pressure and separated by LH-20 Sephadex column, the eluent was 90% % methanol aqueous solution, tracked by polyamide thin-layer chromatography, combined flavonoid fractions, concentrated under reduced pressure and purified by ODS column chromatography, methanol aqueous solution gradient elution, 254nm an...

Embodiment 2

[0036] Such as figure 1 As shown, 0.5kg of cloth dregs leaves and 1.0kg of guava leaves were used as raw materials to obtain active extract parts after extraction, separation and purification. The extraction solvent is 50% ethanol, the ratio of solid to liquid is 1:20, and heated to reflux at 90°C; the crude extract is concentrated under reduced pressure until the alcohol is light, then filtered under reduced pressure, and the supernatant is added with 4 times the volume of purified water and then washed with 1500g macroporous Resin adsorption overnight; then eluted with 10%, 70%, 100% methanol solution, collected 70% methanol eluted part, concentrated under reduced pressure and separated by LH-20 Sephadex column, eluent was 90% methanol Aqueous solution, polyamide thin-layer chromatography tracking, combined flavonoid fractions, concentrated under reduced pressure, purified by ODS column chromatography, gradient elution with methanol aqueous solution, 254nm and 280nm waveleng...

Embodiment 3

[0039] Such as figure 1 As shown, 1.0kg of cloth dregs leaves and 0.5kg of guava leaves were used as raw materials to obtain active extract parts after extraction, separation and purification. The extraction solvent is 60% ethanol, the ratio of solid to liquid is 1:20, and it is heated and refluxed at 90°C; the crude extract is concentrated under reduced pressure until the alcohol is light, then filtered under reduced pressure, and the supernatant is added with 4 times the volume of purified water and then used with 1500g macroporous Resin adsorption overnight; then eluted with 10%, 70%, 100% methanol solution, collected 70% methanol eluted part, concentrated under reduced pressure and separated by LH-20 Sephadex column, eluent was 90% methanol Aqueous solution, polyamide thin-layer chromatography tracking, combined flavonoid fractions, concentrated under reduced pressure, purified by ODS column chromatography, methanol aqueous solution gradient elution, 280nm and 340nm wavele...

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Abstract

The invention provides a plant extract, and a preparation method and application thereof. The plant extract is obtained by extracting paniculate microcos leaves and guava leaves. The plant extract contains more than 60 percent by weight of flavone active substances. The plant extract can eliminate DPPH free radicals in vitro, can remarkably reduce the blood fat of mice fed with high-fat feed, can effectively improve mouse ear swelling inflammation caused by xylene and can protect rat acute myocardial damage caused by isoproterenol. The plant extract derives from pharmacological plants or medicinal and edible plants, is safe and reliable, does not have toxic or side effects, and can serve as novel anti-oxidation, anti-inflammation and fat-reducing medicines or health-care food.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine and natural medicine, and more specifically relates to a plant extract and its preparation method and application. Background technique [0002] Cardiovascular disease is one of the major diseases affecting human health, and oxidative stress and inflammatory response account for a considerable proportion of its pathogenesis. [0003] According to the accepted injury theory, when cholesterol, fat, cell waste and plasma low-density lipoprotein (LDL) accumulated in the blood vessel injury area: on the one hand, LDL is oxidized and modified to become ox-LDL; on the other hand, endothelial Cells turn to macrophages for phagocytosis. After phagocytosis, macrophages transform into foam cells and accumulate to form plaques. At this time, smooth muscle cells proliferate and migrate to cover the plaque and form a fibrous cap, which narrows the arterial channel and reduces the oxygen content of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/61A61P9/10A61P3/06A61P3/10A61P9/14A23L33/105
CPCA23V2002/00A61K36/185A61K36/61A61K2236/333A61K2236/55A61K2300/00A23V2200/30A23V2200/3262A23V2200/326A23V2200/328A23V2250/21
Inventor 李坤平陈艳芬袁旭江
Owner GUANGDONG PHARMA UNIV
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