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Medicament use of myricetin

A new use, medical technology, applied in the field of medicine, can solve problems such as wider application

Inactive Publication Date: 2008-09-03
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Myricetin, as a rare natural active substance, widely exists in a variety of Chinese herbal medicine plants, but it has been developed and sold in the form of crude extracts, which prevents it from being widely used in pharmaceuticals, food additives and other fields , which is also the inadequacy of the current development process of plant natural products in our country

Method used

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  • Medicament use of myricetin
  • Medicament use of myricetin
  • Medicament use of myricetin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: tablet:

[0019] Myricetin 10g

[0020] Powdered sugar 19.5

[0021] Magnesium stearate 0.5g

[0022] 50% ethanol appropriate amount

[0023] Grind myricetin and powdered sugar into fine powder, sieve (100 mesh), mix well, make wet granules with 50% ethanol (20 mesh sieve), dry, granulate (16 mesh sieve), add magnesium stearate , mixed evenly, pressed into 100 tablets, film-coated, and ready to serve.

Embodiment 2

[0024] Embodiment 2: capsules:

[0025] Myricetin 100g

[0026] Starch 20g

[0027] 50% ethanol appropriate amount

[0028] Pulverize myricetin, add starch, mix well, make wet granules with 50% ethanol (20 mesh sieve), dry, granulate (16 mesh sieve), fill in empty capsules, and obtain

Embodiment 3

[0029] Embodiment 3: Granules:

[0030] Myricetin 100g

[0031] 300g powdered sugar

[0032] Dextrin 150g

[0033] Ethanol 5ml

[0034] Pulverize myricetin, powdered sugar and dextrin into fine powder, sieve (100 mesh), mix well, make wet granules with ethanol (20 mesh sieve), dry, sizing (16 mesh sieve) to obtain granules.

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Abstract

The invention discloses a new medical use of myricetin, belonging to the technology field of medicines. Through acetic acid writhing test, formaldehyde-induced pain test, glacial acetic acid-induced capillary permeability test, dimethybenzene-induced mouse ear swelling test, egg white and carrageenin-induced paw edema test, test of leukocytoplania of pleurisy caused by carboxymethyl cellulose, granuloma (chronic) inflammation test, and screening of adjuvant arthritis animal models with primary and secondary inflammations, the myricetin is found to have high antiphlogistic and analgesic activity and can prevent and treat adjuvant arthritis, the antiphlogistic activity of myricetin is equivalent to that of aspirin but no gastrointestinal toxicity, and the anti-rheumatoid arthritis activity of myricetin is equivalent to that of Tripterygium wilfordii, and the myricetin has liver protecting effect and is an ideal drug for preventing and treating acute and chronic inflammations and rheumatoid arthritis. The myricetin can be prepared into various preparations with pharmaceutically-acceptable carrier for relieving inflammations, reliving pain and treating rheumatoid arthritis.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a new medical application of myricetin, in particular to the preparation of myricetin for the prevention and treatment of acute and chronic inflammation, rheumatoid arthritis, treatment of hepatitis, liver protection and health care, and analgesic medicines in the application. Background technique [0002] Inflammation is a common clinical symptom of many diseases, and it is a complex pathological process caused by tissue damage caused by the stimulation of various inflammatory substances. Its main manifestations are local redness, swelling, heat, and pain. Pathological examination can find a large number of inflammatory cell infiltration and tissue necrosis in the inflammatory site. Inflammation is an important protective response of the body to the invasion of inflammatory factors, but at the same time, the inflammatory response has different degrees of damage to the body. Many ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P29/00A61P1/16A61P19/02
Inventor 王淑君佟岩
Owner SHENYANG PHARMA UNIVERSITY
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