The invention provides an
optically active 2-hydroxyltetrahydrothienopyridine derivative shown by formula I, or a pharmaceutically acceptable salt, solvate, polycrystal,
enantiomer or
racemization mixture thereof, wherein in the formula I, R1 is F, Cl, Br or I; m is 0 or 1; n is an integer from 1 to 6; R2 or R3 is independently
hydrogen, C1-C6
alkyl or optionally substituted C1-6
alkyl; R4 or R5 is independently
hydrogen, C1-C10
alkyl, C1-C10 alkenyl, C1-10 alkoxy, C1-10
aryl,
halogen, acylamino, sulfmidyl, acyloxy or C(O)R', and R' is
hydrogen, C1-C10 alkyl, C1-C10 alkenyl, C1-10 alkoxy, C1-10
aryl,
halogen, acylamino, sulfmidyl or acyloxy. The compound has obvious
platelet agglomeration resistance action, and the
bioavailability of the compound is obviously higher than that of
clopidogrel. The invention further provides a preparation method of the compound, a pharmaceutical composition containing the compound, and a pharmaceutical use of the compound and the pharmaceutical composition.