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Application of globeflower flavonoids in preparation of medicine for treating itch dermatoses

A technology of pruritic skin disease and nasturtium, applied in the field of medicine, to achieve the effect of broadening the scope of application, increasing market value, and controlling quality

Inactive Publication Date: 2015-02-04
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report about the anti-itching biological activity of the total flavonoids of Trollica chinensis

Method used

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  • Application of globeflower flavonoids in preparation of medicine for treating itch dermatoses
  • Application of globeflower flavonoids in preparation of medicine for treating itch dermatoses
  • Application of globeflower flavonoids in preparation of medicine for treating itch dermatoses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1, preparation and content determination of total flavonoids of Trollius chinensis

[0013] The preparation method of the total flavonoids of Trollius chinensis, the specific steps are as follows: Weigh 2 kg of Trollius chinensis medicinal material, add water equivalent to 10 times the weight of the medicinal material and decoct twice for 1 hour each time, filter the decoction and combine the filtrate, centrifuge , take the supernatant and go over the macroporous adsorption resin D101 column (weak polarity, Tianjin Haiguang Chemical Co., Ltd.), then wash it with 0.2% hydrochloric acid solution until the effluent is colorless, then wash it with distilled water until the effluent The solution was neutral, and then eluted with ethanol solution with a volume fraction of 50%. The ethanol eluate was collected, concentrated under reduced pressure, and dried to obtain total flavonoids of Trollica chinensis. Utilize this method to obtain the amount of total flavonoids...

Embodiment 2

[0020] Embodiment 2, the pharmacological effect of total flavonoids of Trollius chinensis

[0021] 1. The emulsifiable paste made from total flavonoids of Trollius vulgaris in Example 1 detects the influence of total flavonoids of Trollius vulgaris on chronic eczema model

[0022] Get 50 Kunming male mice whose body weight is about 20g, and divide them into 5 groups at random, 10 in each group, respectively the control group, the model group, the Ai Luo Song group, the high total flavonoids of Trollius chinensis (drug content 2%, w / w), medium (drug content 1%, w / w), low dose group (drug content 0.5%, w / w). On the day before the experiment, the hair was removed on the abdomen, with an area of ​​about 3×3cm 2 . Except for the control group, the rest of the groups were evenly coated with 1% 2,4-dinitrofluorobenzene (DNFB) on the abdominal hair removal area, 100 μL / body was sensitized, and the next day was strengthened once, and the first sensitization On the 7th day, 12th day...

Embodiment 3

[0055] Embodiment 3, the acute toxicity of total flavonoids of Trollius chinensis

[0056] Get 40 mice with a body weight of 20 ± 2g, half male and half male, each mouse is given total flavonoids of Trollica chinensis (equivalent to crude drug 20g / kg) at a dose of 1.0g / kg (body weight), and administered by oral gavage every day 3 times, continuous administration for 7 days, observe whether the mice have acute toxicity.

[0057] The results showed that when the total flavonoids of nasturtium lotus was orally administered to mice (10 mg / kg in mice), which was equivalent to 100 times the dose of human medicine, no mice died and LD was not detected. 50 . The above results show that the total flavonoids of Trollius chinensis has good safety, which is equivalent to 100 times the dosage of human medicine, and no death of mice has been seen.

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Abstract

The invention discloses an application of globeflower flavonoids in preparation of a medicine for treating itch dermatoses. The application range of globeflower flavonoids is expanded; a novel medicine is provided for treatment of itch dermatoses; from a pharmacology experiment, the globeflower flavonoids have good prevention and treatment effects on a mice chronic eczema model, have an obvious inhibiting effect on mice delayed-type allergic reaction caused by 2,4-dinitrofluorobenzene, have obvious anti-inflammatory effect in ear swelling in mice caused by xylene, and have a significant inhibiting effect on capillary permeability increase in mice caused by glacial acetic acid; and the globeflower flavonoids can have relatively good counteraction on guinea pig pruritus caused by histamine phosphate, are low in toxicity and safe to use, and have a relatively good application prospect.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of total flavonoids of nasturtium in the preparation of medicines for treating pruritus skin diseases. Background technique [0002] Pruritic dermatosis refers to a group of dermatoses characterized by pruritus, including eczema, psoriasis, papular urticaria, insect bite dermatitis, and pityriasis erythra. In recent years, the incidence of pruritic skin diseases has been on the rise, which is related to climate change, the application of a large number of chemicals in daily life, mental stress, accelerated pace of life, and changes in dietary structure. , pruritus and the lingering course of the disease affect the quality of life of patients and bring great distress to patients. At present, the external drugs used to treat pruritus skin diseases are mainly glucocorticoids and a small amount of Chinese patent medicine preparations. The initial effect of glucoco...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61P17/04A61P17/06A61P17/00
CPCA61K36/71A61K2236/331A61K2236/51A61K2236/55
Inventor 陈盛孙凤军王显凤廖伟冯伟邱学文
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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