39 results about "Oral gavage" patented technology

Methods, compositions and devices are provided by the present invention for reducing activity of a natriuretic peptide receptor and other signals. Therapeutic treatments are provided by use of polynucleotides encoding a natriuretic peptide or by regulating the expression of natriuretic peptide receptor, such as NPRA and NPRC, or combinations of these therapies. Routes used for delivering polynucleotides encoding a natriuretic peptide, or, for example, siRNA that down regulates natriuretic peptide receptor include subcutaneous injection, oral gavage, transdermal and intranasal delivery routes. Compositions can include chitosan, chitosan derivatives, and chitosan derivative and a lipid. Transdermal delivery can use a transdermal cream. Intranasal delivery can use a dropper or an aspirator for delivery of a mist. Oral gavage delivers equivalent to oral delivery. Delivery permits cell and tissue specific targeting of gene therapies resulting in expression of a natriuretic peptide or down regulation of natriuretic peptide receptor. A variety of cancers, asthma and viral diseases can be treated therapeutically using the methods and compositions of the present invention.

The invention discloses a sodium aescinate micro-emulsion injection. The formula of the sodium aescinate micro-emulsion injection comprises sodium aescinate, an oil phase, a surfactant and a cosurfactant. Compared with the oral gavage, the sodium aescinate micro-emulsion injection for intravenous injection provided by the invention has the advantages that the bioavailability is high, the concentration of the injection in the liver can be increased obviously, the concentration of the injection in the kidney can be reduced, meanwhile, the irritation on the wall of the blood vessel is alleviated, and the generation times of phlebophlogosis can be reduced, so that the curative effect is improved, and the toxic and side effect is lowered.

A nutritional composition for gastrostomy-tube patients who are at an increased development risk of aspiration pneumonia and require careful risk management, which can be more safely consumed by gastrostomy-tube patients while suppressing the development of aspiration pneumonia, is administered to those patients who require risk management for aspiration pneumonia, and contains a protein source, a carbohydrate source, and a lipid source, the protein source including only amino acids.

The invention discloses recombinant lactococcus lactis based on the fbsA gene of Streptococcus agalactiae. The recombinant lactococcus lactis comprises the fbsA gene of Streptococcus agalactiae or segments of the fbsA gene, the fbsA gene or the segments of the fbsA gene preferably has (or have) a sequence shown in SEQ ID No. 1, the deposit number of the recombinant lactococcus lactis is CCTCC M 2020140, and expression of recombinant FbsA protein with a theoretical molecular weight of 34.6 kDa can be induced under the culture condition that niusin exists. The invention also provides a vaccine for the Streptococcus agalactiae disease of Oreochromis sp., and the vaccine is prepared from the recombinant lactococcus lactis, and is capable of producing protective antibodies in Oreochromis sp. after Oreochromis sp. is fed with the vaccine in an immune mode of oral gavage, so that Oreochromis sp. is assisted to resist infection of Streptococcus agalactiae effectively.

Compositions for oral administration to a young poultry bird, such as a chicken, that comprise cecal material from adult poultry birds and saline are disclosed. The compositions can be used to increase body weight gain in a poultry bird by administering them to a young bird by oral gavage. The compositions may also be used to increase feeding efficiency in a poultry bird. Further disclosed are compositions for application to poultry litter, for example, chicken litter, that are prepared using the cecal material from adult poultry bird. The compositions may be used to prevent or reduce colonization of the chicken gut by pathogenic bacteria. Also disclosed are method of selecting for bacterial strains with probiotic potential.

The invention discloses a bacterial ghost preparation method of an independent lysis gene E. According to the preparation method, a bacterium suspension solution is added with four chemical substances including NaOH, Triton X-100, Na2EDTA and H2O2 to prepare the bacterial ghost in order to satisfy the requirements of complete release of bacterium content and completeness of a bacterium ghost. The method is simple and rapid to operate; except lysis holes, the cell shape and surface structure of the prepared bacterial ghost are not obviously changed. The bacterial ghost prepared by the method disclosed by the invention can enter a specific cell in a targeted manner, is free of toxicity to the cell and can be used as a novel transferring carrier for a drug. The bacterial ghost prepared by the method disclosed by the invention can also be used for immunizing a BALB / c mouse by intraperitoneal injection or oral gavage, also has quite good protection efficiency to homologous counteracting toxic substances and can be used as a novel vaccine.

The invention relates to the industries of functional food and medicine, in particular to a glucosamine chondroitin sulfate salt as well as a preparation method and application thereof. The structuralformula of the glucosamine chondroitin sulfate salt is shown as a formula (1), and the value range of the average polymerization degree n is 5-1000. The glucosamine chondroitin sulfate salt is obtained by performing ion exchange on glucosamine hydrochloride or sulfate or phosphate and chondroitin sulfate sodium, or dialyzing with a mixed solution, or directly precipitating with the mixed solution, , the molecular weights of chondroitin sulfates are all polysaccharides which are obtained through natural extraction, fermentation preparation or degradation, or a synthesis method and accord withthe chondroitin sulfate structures. The chondroitin sulfate and glucosamine are organically combined together, the glucosamine chondroitin sulfate salt is different from an existing compound product of the chondroitin sulfate and the glucosamine, the glucosamine chondroitin sulfate salt does not contain micromolecular inorganic salts or is very low in content of the micromolecular inorganic salts,and the prepared glucosamine chondroitin sulfate salt has a good treatment effect on osteoarthritis model rats in an oral gavage mode; the micromolecular inorganic salts be used for but not limited to joint treatment or auxiliary health care. The glucosamine chondroitin sulfate salt can be widely applied to the fields of functional foods and medicines.

We report for the first time that pterostilbene, a natural analog of resveratrol, shows anxiolytic-like action by downregulating phosphorylated levels of ERKs in the hippocampus of mice. Mice administered pterostilbene (1-10 mg / kg BW) by oral gavage were subjected to the Elevated-plus maze (EPM) test. Pterostilbene manifested anxiolytic activity at 1 and 2 mg / kg doses, demonstrated by an increase in percent permanence time and number of entries in open arms, critical determinants correlated with anxiety. This anxiolytic activity of pterostilbene was comparable to that of diazepam at 1 and 2 mg / kg in the EPM. The percent traveled distance and the percent permanence time in the enclosed arms were decreased with the 1 and 2 mg / kg doses. The 5 and 10 mg / kg doses did not show any anxiolytic effect. Locomotor activity was unaffected in all doses. Western blot analysis corroborated the observed behaviors in the EPM, revealing a decrease in both ERK1 and ERK2 phosphorylation in hippocampal homogenates from mice treated with 1 and 2 mg / kg doses; the 5 and 10 mg / kg doses showed no significant effect on the phosphorylation of ERKs. Pterostilbene was detected in serum and brain tissue following a single oral administration, demonstrating that the compound can cross the blood-brain barrier to reach the brain regions, including hippocampus, and thereby exert its anxiolytic effect. Resveratrol, the parent molecule of pterostilbene, did not have any anxiolytic effect.

The invention belongs to the technical field of medical instruments, and discloses a hydrops drainage device for the cardiovascular medicine department, which comprises a suction bottle and a bottle rack, the suction bottle is clamped on the bottle rack through a lantern ring, the suction bottle is connected with a suction pipe, a negative pressure pipe and a first flow guide pipe in a sealed mode, the suction pipe is sleeved with a guide pipe, the negative pressure pipe is connected with a negative pressure suction pump. the inner side of the suction bottle is connected with a collecting plate, the lower end of the first flow guide pipe is sleeved with a flow guide pipe adjuster and an arch-shaped buffer pipe, the arch-shaped buffer pipe is connected with a liquid flowmeter, a liquid outlet pipe of the liquid flowmeter is connected with a second flow guide pipe, the second flow guide pipe is connected with a liquid three-way valve, two liquid outlets of the liquid three-way valve are respectively in pipe connection with a first liquid outlet pipe and a second liquid outlet pipe, the first liquid outlet pipe is connected with a first hydrops bottle, and the second liquid outlet pipe is connected with a second hydrops bottle. The hydrops drainage device solves the problems that in the drainage process of an existing hydrops drainage device, a hydrops bottle cannot be replaced, and the hydrops amount detection precision is low, and is suitable for hydrops drainage in the cardiovascular medicine department.

We report for the first time that pterostilbene, a natural analog of resveratrol, shows anxiolytic-like action by downregulating phosphorylated levels of ERKs in the hippocampus of mice. Mice administered pterostilbene (1-10 mg / kg BW) by oral gavage were subjected to the Elevated-plus maze (EPM) test. Pterostilbene manifested anxiolytic activity at 1 and 2 mg / kg doses, demonstrated by an increase in percent permanence time and number of entries in open arms, critical determinants correlated with anxiety. This anxiolytic activity of pterostilbene was comparable to that of diazepam at 1 and 2 mg / kg in the EPM. The percent traveled distance and the percent permanence time in the enclosed arms were decreased with the 1 and 2 mg / kg doses. The 5 and 10 mg / kg doses did not show any anxiolytic effect. Locomotor activity was unaffected in all doses. Western blot analysis corroborated the observed behaviors in the EPM, revealing a decrease in both ERK1 and ERK2 phosphorylation in hippocampal homogenates from mice treated with 1 and 2 mg / kg doses; the 5 and 10 mg / kg doses showed no significant effect on the phosphorylation of ERKs. Pterostilbene was detected in serum and brain tissue following a single oral administration, demonstrating that the compound can cross the blood-brain barrier to reach the brain regions, including hippocampus, and thereby exert its anxiolytic effect. Resveratrol, the parent molecule of pterostilbene, did not have any anxiolytic effect.

The invention discloses a test method of developmental toxicity of silkworms by environmental estrogen. The method includes following steps: firstly, injecting a test sample containing a series of concentrations to 5-age silkworm larvae through 2-hour starvation treatment by employing oral gavage; after 20 minutes, performing anatomy on the silkworms through gavage, and taking tissues and organs;determining the developmental toxicity of the silkworms by the test sample through comparison of toxic endpoints of an infected group and a control group, wherein the toxic endpoints comprise a glutathione reductase activity coefficient and an anti-superoxide anion free radical activity of midguts of the silkworms; and researching the influence of the environmental estrogen 4-nonylphenol on the development of the midguts of the silkworms in a larva stage to determine a dose-effect relation between the environmental estrogen and the developmental toxicity of the silkworms in the larva stage. Byemploying the technical scheme, multiple biological effect endpoints can be generated for the environmental estrogen nonylphenol, potential risks of the silkworms exposed in an estrogen environmentalconcentration level are evaluated, and the method is a relatively fast, simple and sensitive detection method.

The invention discloses an application of inonotus obliquus or an inonotus obliquus extract in preparation of a medicine for resisting ventricular remodeling. Two clinically related ventricular remodeling disease models, namely isoprenaline (ISO) subcutaneous injection induced mouse ventricular remodeling and aortic arch constriction (TAC) induced mouse ventricular remodeling, are adopted. The experiments prove that oral gavage of inonotus obliquus can obviously inhibit occurrence and development of ISO subcutaneous injection and TAC operation induced mouse ventricular remodeling, and it is clear that effective active monomer components in inonotus obliquus triterpenes comprise lanosterol, inonotus obliquus alcohol, 3 beta-hydroxyl lanostane-8, 24-diene-21-aldehyde and 3 beta-hydroxyl lanostane-8, 24-diene-21-acid. The product can be used for preventing and treating ventricular remodeling of patients.

The invention relates to application of demethylwedelolactone-7-sulphate in preparation of an anti-pulmonary fibrosis medicine. The compound demethylwedelolactone-7-sulphate is obtained from a traditional Chinese medicinal material eclipta for the first time, and the structure is determined by virtue of NMR (nuclear magnetic resonance) and other spectrum data; In-vivo and in-vitro pharmacological experiment results prove that the demethylwedelolactone-7-sulphate can be used for remarkably inhibiting proliferation of TGF (transforming growth factor)-beta1 induced human embryonic lung fibroblast and HYP (hydroxyproline) content thereof, and inflammation and fibrosis degree of the lung tissue in a bleomycin induced mouse pulmonary fibrosis model can be improved in the oral gavage dosing range of 5-30mg / kg, the MDA (methylene dioxyamphetamine) content reflecting the lung injury degree in the lung tissue can be influenced, the HYP content reflecting lung tissue collagen deposition can be reduced, and the cytokine TGF-beta1 content causing pulmonary fibrosis can be reduced, so that the pharmacological action of the pulmonary fibrosis degree can be improved. The demethylwedelolactone-7-sulphate has novel application in medicines for treating or improving pulmonary fibrosis diseases.

The invention belongs to the technical field of medical instruments, and discloses a drainage device for nursing in the ICU. The drainage device comprises a base, wherein universal wheels are connected to the lower side of the base; a drainage pump, a handrail, a second guide pipe and a hydrops bottle are connected to the upper side of the base; a damper spring is connected to the second guide pipe; a placement plate is connected to the damper spring; the placement plate is connected with a drainage frame; the drainage frame is connected with a suction bottle; a negative pressure pipe and a limiting pipe are a penetrated in the suction bottle in a sealing way; the limiting pipe is provided with a placement groove and an inflation branch pipe; a limiting air bag is connected in the placement groove; the limiting pipe is connected with a drainage pipe; a liquid outlet is arranged on the lower end of the suction bottle; two sides of the liquid outlet are respectively connected with a first guide pipe; the first guide pipe is connected with a flow limiting spring; the flow limiting spring is connected with a flow limiting plate; and the liquid outlet is in pipe connection with a flow guide pipe. The problems in the prior art that the drainage device is too high in drainage speed and a drainage pipe is likely to fall off are solved, and the drainage device disclosed by the invention is suitable for the ICU to carry out drainage.

Disclosed are an oxygen humidifying liquid bag and an oxygen humidifying device. The oxygen humidifying liquid bag comprises a bag body and a mouth tube component; the mouth tube component is connected to the bag body in a sealed mode; the mouth tube component is provided with an internal channel communicating with an inner cavity of the humidifying liquid bag; an inner cavity of the humidifying liquid bag is used for containing humidifying liquid; the internal channel of the mouth tube component is provided with a humidifying liquid outlet; the humidifying liquid bag further comprises a slender humidifying liquid conveying channel extending to the lower portion of the humidifying liquid bag body; the upper portion of the humidifying liquid conveying channel communicates with the internal channel of the mouth tube component; the humidifying liquid conveying channel is provided with at least one lower opening; the lower opening of the humidifying liquid conveying channel communicates with the inner cavity of the humidifying liquid bag; the oxygen humidifying device comprises a container with an oxygen inlet structure and an oxygen outlet structure; a part or all of an inner cavity of the container can be used for humidifying oxygen; the oxygen humidifying device further comprises a humidifying liquid pump and an oxygen humidifying liquid bag connecting structure; humidifying liquid is sucked into the humidifying liquid pump through the humidifying liquid outlet via the connecting structure; and the humidifying liquid enters the inner cavity of the container through a pump outlet structure of the humidifying liquid pump.

The invention discloses a medical liquid container filling system. The system a filling nozzle, a medical liquid line, a valve, a filling port tube clamp, a sensor and a control unit, wherein the medical liquid line leads to the filling nozzle, and the valve is arranged along the medical liquid line; the filling port tube clamp is used for grasping a filling port tube of a medical liquid container, wherein 1) the clamp is movable to move the filling port tube onto the filling nozzle to form an overlapping portion, or 2) the filling nozzle is movable to move the filling nozzle into the fillingport tube to form an overlapping portion; the sensor is positioned and arranged to detect the overlapping portion between the filling port tube and the filling nozzle; and the control unit is configured to receive an output of the sensor and to determine from the output whether the overlapping portion exists or not between the filling port tube and the filling nozzle, and the control unit is further configured to reject opening the valve if the overlapping portion does not exist.

The invention discloses a sodium aescinate micro-emulsion injection. The formula of the sodium aescinate micro-emulsion injection comprises sodium aescinate, an oil phase, a surfactant and a cosurfactant. Compared with the oral gavage, the sodium aescinate micro-emulsion injection for intravenous injection provided by the invention has the advantages that the bioavailability is high, the concentration of the injection in the liver can be increased obviously, the concentration of the injection in the kidney can be reduced, meanwhile, the irritation on the wall of the blood vessel is alleviated, and the generation times of phlebophlogosis can be reduced, so that the curative effect is improved, and the toxic and side effect is lowered.

The invention relates to the technical field of medical instruments, and discloses a dual-purpose nursing device for the obstetrics and gynecology department and the birth canal for thoroughly scraping dirt on the inner wall of a birth canal. The device comprises a handheld component, a spiral thread is arranged on the upper end surface of a rotary disc; a metal ball is arranged at the right end of a sliding rod; a metal sheet corresponding to the metal ball is arranged in a sliding cylinder; semicircular lining plates are respectively connected to the outer side ends of the sliding rod and the sliding cylinder; a spiral groove is formed in sponge; the outer side of a transverse plate is connected with a ball; the lower end of a second spring is connected with an elastic ball; cleaning liquid in the cleaning liquid tank is separated from a liquid through groove through the elastic ball on the left side and enters the left part of the ball through a liquid inlet pipe; a first liquid receiving tube enters the upper part of the spiral groove and cleans the inner wall of the vagina by the sponge; and similarly, waste liquid is pumped out of a recovery liquid tank from top to bottom through a liquid pump arranged in the recovery liquid tank. The structure solves the problems that an existing cleaning and nursing device for the obstetrics and gynecology department is low in cleaningefficiency and liquid is prone to leaking.

The invention discloses an ophthalmic nursing liquid medicine dripping device and a mounting and using method thereof, and relates to the technical field of ophthalmic nursing. An eyelid pressing silica gel plate is extruded and clamped into a fixed clamping plate; a propelling and dripping assembly is slidably mounted on a handheld rod, the upper side of a sliding body is fixedly connected with an extended fixed pipe, and a dripping pipe head is communicated with an upstream connector pipe; a liquid guide fixing assembly is fixedly mounted at the other side end of the handheld rod, the liquid guide fixing assembly comprises a fixed mounting piece fixedly connected with the handheld rod in a matched mode, a downstream liquid conveying opening pipe is arranged on the bottom side of the fixed mounting piece, and one end of the fixed mounting piece is connected with an end mounting cover body; the end mounting cover body comprises an end mounting groove and an injection port positioned at the bottom of the end mounting groove, the injection port is communicated with the downstream liquid conveying opening pipe, and the end mounting cover body is in threaded connection with a bag-shaped tail bottle; and the handheld rod is provided with a strip-shaped through slot. Eyedrops can be correctly dropped, and the intense foreign body sensation of an eyedrops bottle or a dropping device to the eyes when the eyedrops are dropped is also reduced.

The present invention relates to the technical field of pharmaceuticals and specifically describes an application of a 5-hydroxytryptamine receptor 1A in preparing a drug for portal hypertension. The present invention achieved a significant decrease in portal venous pressure in model rats with cirrhotic portal hypertension by means of an HTR1A inhibitor WAY100635 administered at 1 mg / kg / day by intraperitoneal injection or alverine administered at 15 mg / kg / day by oral gavage. A 5-hydroxytryptamine receptor 1A antagonist can be used to prepare an experimental drug for the treatment of cirrhotic portal hypertension. Furthermore, the 5-hydroxytryptamine receptor 1A antagonist can also be used to prepare drugs for symptoms of portal hypertension syndrome, such as esophageal and fundal varices, rupture and bleeding, ascites, or hepatic encephalopathy. The present invention provides a novel treatment means to treat the manifestations of portal hypertension syndrome, such as esophageal and fundal varices, rupture and bleeding, ascites, or hepatic encephalopathy.

The invention relates to a strain of Bacillus amyloliquefaciens and its application in preventing diarrhea of ​​weaned piglets. The present invention provides a Bacillus amyloliquefaciens strain BA40, which can inhibit common porcine enteropathogens Escherichia coli K88, Salmonella typhimurium and Staphylococcus aureus, and has acid resistance, bile salt resistance and pancreatin resistance Ability. After the bacillus amyloliquefaciens is activated, its number of live bacteria reaches 10 8 -10 9 CFU / mL, oral gavage of 6-day-old suckling piglets, continuous gavage of 1 mL until weaning on 24 days. The Bacillus amyloliquefaciens provided by the invention can increase the weaning weight gain of piglets and the diversity of intestinal flora, reduce diarrhea in weaned piglets, reduce the rate of diarrhea, reduce inflammatory factors, promote nutrient absorption, and improve the body's antioxidant capacity ability and disease resistance, providing a new way for nutritional regulation in non-antibiotic farming.

The invention discloses an artificial respiration device for nursing in the department of cardiology. The device comprises a tooth socket. The detection device comprises an air inlet thread, an air outlet thread port, a converging port, a pipe groove, a rectangular groove and a rotary column. An arc-shaped rod is connected with the middle of the upper end of the detection device. The upper end ofthe arc-shaped rod is connected with an airbag ball. The other end of an air inlet pipe is connected with an air blowing cover. The lower side of the detection device is connected with a liquid discharge pipe. An illuminating lamp and a light sensor are arranged in the detection device respectively. Feathers are connected with the inside detection device. Exhaled air is exhausted from an air outlet pipe through the pipe groove. The feathers in the rectangular groove rotate around the rotary column through an arc-shaped pipe. The light sensor can receive strong illumination of the illuminatinglamp. A valve in an oxygen pipe is opened, and oxygen is supplied to a patient in a matched mode when the patient inhales. The structure solves the problem that an existing oxygen supply device supplies oxygen all the time and cannot supply oxygen in cooperation with the respiratory rate of the patient.

The invention relates to the technical field of medical instruments, and discloses a dual-purpose nursing device for the obstetrics and gynecology department and the birth canal for thoroughly scraping dirt on the inner wall of a birth canal. The device comprises a handheld component, a spiral thread is arranged on the upper end surface of a rotary disc; a metal ball is arranged at the right end of a sliding rod; a metal sheet corresponding to the metal ball is arranged in a sliding cylinder; semicircular lining plates are respectively connected to the outer side ends of the sliding rod and the sliding cylinder; a spiral groove is formed in sponge; the outer side of a transverse plate is connected with a ball; the lower end of a second spring is connected with an elastic ball; cleaning liquid in the cleaning liquid tank is separated from a liquid through groove through the elastic ball on the left side and enters the left part of the ball through a liquid inlet pipe; a first liquid receiving tube enters the upper part of the spiral groove and cleans the inner wall of the vagina by the sponge; and similarly, waste liquid is pumped out of a recovery liquid tank from top to bottom through a liquid pump arranged in the recovery liquid tank. The structure solves the problems that an existing cleaning and nursing device for the obstetrics and gynecology department is low in cleaningefficiency and liquid is prone to leaking.

The invention relates to the technical field of animal experiment equipment, in particular to an animal alcohol addiction experiment device which comprises a regulation and control part used for regulating and controlling alcohol flow and a plurality of distillation boxes used for carrying out alcohol addiction experiments. The oxygen flow divider and the distillation box are respectively communicated and connected through an air pipeline and an alcohol pipeline, flow meters are arranged on the air pipeline and the alcohol pipeline, and suction filtration bottles for storing alcohol are arranged on the alcohol pipeline and between the flow meters and the distillation box; a gas collecting piece is arranged on the distillation box in a penetrating manner. The invention provides a novel device for an animal alcohol addiction experiment, and overcomes the technical defects of an oral gavage method.

The invention relates to a preparation method and application of an usnea nicotinamide compound, belonging to the technical field of medicinal chemistry. The structure of the compound is shown in formula (I):, formula (I); its preparation method is to use usnezone and nicotinic acid as substrates, in an organic solvent medium, with N,N'-diisopropyl carbon Diimide is a dehydrating agent and 4-dimethylaminopyridine is a catalyst, and the compound with significant anticancer activity is prepared by acylation reaction at room temperature. The raw material of the synthesis method is easy to obtain, the steps are simple and fast, and the product is easy to purify. The acute toxicity of Usnea Niacinamide by oral gavage in mice was classified as non-toxic, and the experimental dose had no obvious toxicity on animal survival, weight gain, organ development, liver and kidney tissue, blood biochemical and blood routine indicators. The compound of the invention has significant anti-tumor effect, can be used for preparing anti-tumor chemotherapeutic drugs and auxiliary anti-tumor health products, and has good application prospect.

The invention belongs to the field of separation pick-up devices, and specifically discloses an intelligent bionic separation pick-up device, a manufacturing method and a separation pick-up method, which are integrally formed of a shape memory alloy material, including a main body of an orifice tube, a water circulation channel, a pair of upper jaws of an orifice tube and A plurality of tongue-shaped bristles, the main body of the mouth tube is a round tube with thick ends and a thin middle, the water circulation channel is a ring-shaped channel in the inner wall of the main body of the mouth tube, a pair of upper jaws of the mouth tube are located at one end of the main body of the mouth tube, and are symmetrically distributed, Multiple tongue-like setae are located on both sides of the inner wall of the main body of the mouth tube; when the temperature is lower than the complete austenitization temperature of the shape memory alloy, the upper jaw of the mouth tube is opened, and the tongue-like setae are all facing one side; when the temperature is higher than the complete austenitization temperature of the shape memory alloy At the martensitizing temperature, the upper jaw of the mouth tube is closed, the main body of the mouth tube is twisted, and the tongue-like bristles are stretched and turned to the other side; through the deformation and cooperation of various parts at different temperatures, separation and picking are realized. The structure is simple, intelligent, and has good performance. operability and practicality.