The invention relates to a compound sodium aescinate cataplasm, which comprises an outer lining layer, a medicament tank and a protective layer, wherein the medicament tank layer comprises sodium aescinate, diethylamine salicylate, a framework material, a tackifier, a humectants, a penetration enhancer, a cross-linking agent, a cross-linking regulator, a pH value regulator, A preservative, a spice, a filler, water, antioxygen and the like. The compound sodium aescinate cataplasm can carry a large amount of medicament, has high moisturizing performance and breathability, is convenient to use, can improve treatment effect and is free from side effects such as sensitization.