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Double-drug-loaded nanofiber hydrogel composite cartilage repair system and preparation method thereof

A technology for repairing nanofibers and cartilage, which can be used in pharmaceutical formulations, fiber treatment, cellulose/protein conjugated artificial filaments, etc. It can solve the problems of acidic degradation products, slow degradation rate, and easy to cause inflammation of surrounding tissues. Improve cartilage repair effect, simple preparation method, and favorable adhesion effect

Active Publication Date: 2022-01-18
湖北华旭达药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Polylactic acid is a green polymer material with sufficient sources of raw materials, pollution-free and biodegradable. At the same time, polylactic acid also has good mechanical and physical properties and is easy to be processed into films, but the degradation rate is slow, and The degradation products are acidic, which can easily cause inflammation of the surrounding tissue, and generally need to be compounded with other materials

Method used

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  • Double-drug-loaded nanofiber hydrogel composite cartilage repair system and preparation method thereof
  • Double-drug-loaded nanofiber hydrogel composite cartilage repair system and preparation method thereof
  • Double-drug-loaded nanofiber hydrogel composite cartilage repair system and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A double drug-loaded nanofiber hydrogel composite cartilage repair system, the preparation method is as follows:

[0042] 1) Preparation of drug-loaded coaxial nanofibers

[0043] Dissolve 1 g of polylactic acid and 0.001 mg of kartogenin powder in 15 mL of dichloromethane as the core spinning solution. Dissolve 0.5g of silk fibroin in 16g of hexafluoroisopropanol as the shell spinning solution. Put the core layer solution and the shell layer solution in 5mL disposable syringes respectively. After connecting the coaxial experimental device, set the core layer solution to be pushed out at a speed of 0.15mm / min, and the shell layer spinning solution to be pushed out at a speed of 0.15mm / min. , the voltage between the coaxial needle tube and the receiving plate is 11KV, the receiving distance is 6cm, the ambient temperature is 25°C, and the relative humidity is 30%. Coaxial electrospinning is carried out to obtain drug-loaded coaxial nanofibers, which are recorded as poly...

Embodiment 2

[0053] A double drug-loaded nanofiber hydrogel composite cartilage repair system, the preparation method is as follows:

[0054] 1) Preparation of drug-loaded coaxial drug-loaded nanofibers

[0055] Dissolve 1 g of polylactic acid and 0.01 mg of kartogenin powder in 15 mL of dichloromethane as the core spinning solution. 1g of silk fibroin was dissolved in 32g of hexafluoroisopropanol as the shell spinning solution. Put the core layer solution and the shell layer solution in 5mL disposable syringes respectively. After connecting the coaxial experimental device, set the core layer solution to be pushed out at a speed of 0.1mm / min, and the shell layer spinning solution to be pushed out at a speed of 0.2mm / min. , the voltage between the coaxial needle tube and the receiving plate is 11KV, the receiving distance is 8cm, the ambient temperature is 25°C, and the relative humidity is 30%. Coaxial electrospinning is carried out to obtain drug-loaded coaxial nanofibers.

[0056] 2) P...

Embodiment 3

[0061] This example is basically the same as Example 1, except that the amount of oxidized hydroxyethyl cellulose in step 2) is 0.3 g.

[0062] 1) Preparation of drug-loaded coaxial drug-loaded nanofibers

[0063] Dissolve 1 g of polylactic acid and 0.0005 mg of kartogenin powder in 15 mL of dichloromethane as the core spinning solution. Dissolve 0.3g of silk fibroin in 16g of hexafluoroisopropanol as the shell spinning solution. Put the core layer solution and the shell layer solution in 5mL disposable syringes respectively. After connecting the coaxial experimental device, set the core layer solution to be pushed out at a speed of 0.1mm / min, and the shell layer spinning solution to be pushed out at a speed of 0.2mm / min. , the voltage between the coaxial needle tube and the receiving plate is 11KV, the receiving distance is 8cm, the ambient temperature is 25°C, and the relative humidity is 30%. Coaxial electrospinning is carried out to obtain drug-loaded coaxial nanofibers, ...

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Abstract

The invention discloses a double-drug-loaded nanofiber hydrogel composite cartilage repair system. Kartogenin-loaded coaxial nanofibers are used as a skeleton, and gaps of the skeleton are filled with sodium aescinate-loaded composite hydrogel, so that an elastic cylinder is finally formed, wherein the coaxial nanofibers consist of a core layer and a shell layer, the core layer is polylactic acid, the kartogenin is uniformly dispersed in the polylactic acid, and the shell layer is silk fibroin; the composite hydrogel consists of sodium aescinate, chitosan and oxidized hydroxyethyl cellulose, and the sodium aescinate is uniformly dispersed in the chitosan. The double-drug-loaded nanofiber hydrogel composite cartilage repair system has excellent biocompatibility and mechanical properties, a coaxial fiber membrane can provide correct guidance for cartilage regeneration, and meanwhile, double-drug-loaded gradient release can promote cartilage repair in different stages, so that the quality of cartilage repair is guaranteed.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a cartilage repair system, in particular to a double drug-loaded nanofiber hydrogel composite cartilage repair system, and also relates to a preparation method thereof. Background technique [0002] In clinical orthopedic treatment, there are a large number of cases of cartilage defects caused by various reasons such as arthritis and sports injuries. The treatment methods are usually to clean up the defect, inject anti-inflammatory drugs to relieve the pain of the patient, and perform reconstruction with autologous bone transplantation. Due to the special structure of cartilage tissue, once a cartilage defect occurs in the human body, it is difficult to recover through the body's self-healing ability, so there is no good method for repairing articular cartilage defects. [0003] With the development of materials engineering, some new biomimetic tissue repair materi...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/18A61L27/22A61L27/20A61L27/50A61L27/52A61L27/54D01F8/14D01F8/02D04H1/728D01D5/00D01D5/34
CPCA61L27/18A61L27/227A61L27/20A61L27/50A61L27/52A61L27/54D01F8/14D01F8/02D04H1/728D01D5/003D01D5/34A61L2400/12A61L2430/06A61L2300/41A61L2300/602A61L2300/412A61L2300/216C08L67/04C08L89/00C08L5/08C08L1/284
Inventor 许沛虎岳云卿徐海星黄志军李科比文景徐静怡任姝仪李洋毅许敏祝宸玥李赟慧王子怡
Owner 湖北华旭达药业有限公司
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