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Sodium aescinate toothpaste and preparation method thereof

The technology of aescin sodium and toothpaste is applied in the field of daily chemicals, which can solve the problems that have not yet been discovered, and achieve the effects of avoiding adverse reactions, preventing and treating bleeding, and promoting the dissolution and absorption of hematoma.

Inactive Publication Date: 2015-04-08
FUJIAN MINDONG REJUVENATION PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Through searching the literature and patents, no toothpaste that uses sodium aescinate as a traditional Chinese medicine additive to improve oral gum swelling and bleeding symptoms has been found

Method used

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  • Sodium aescinate toothpaste and preparation method thereof
  • Sodium aescinate toothpaste and preparation method thereof
  • Sodium aescinate toothpaste and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: a kind of sodium aescinate toothpaste, calculated in 100g paste, contains the following components:

[0023]

Embodiment 2

[0024] Embodiment 2. Intermittent two-step paste method

[0025] Weigh the materials according to the amount of medicine marked in the formula;

[0026] Put glycerin and sodium carboxymethyl cellulose into the glue pot, moisten and stir, then add dissolved saccharin sodium, refined water and other raw materials, and continue to stir, so that the prepared glue is in a uniform translucent viscous liquid state, and then stored , let it fully melt and expand before use;

[0027] Put all kinds of solid powder raw materials and prepared glue, essence, etc. into the mixing pot according to the formula and operation requirements, and mix them evenly through mechanical mixing to make a paste with certain viscosity and appropriate thickness;

[0028] After the paste is ground by a grinder, the over-coarse and hard particles can be ground to make the paste fine, uniform and stable. The grinding can be divided into two times. The first grinding is stored after the second grinding, and th...

Embodiment 3

[0030] Embodiment 3. dry method one-step paste method

[0031] The medicinal ingredients in the above formula (aescin sodium), glycerin (humectant), sodium carboxymethylcellulose (thickener), carrageenan (thickener), sodium saccharin (sweetener), Ethyl hydroxybenzoate (antibacterial preservative) and purified water are put into the paste making machine and vacuumized. When the pot reaches a certain vacuum degree (-0.096Mpa), silicon dioxide (friction agent) and sodium lauryl sulfate ( Surfactant), homogeneous stirring, homogenization while degassing, after homogenization is completed, add spices, homogeneous degassing for several minutes, to obtain the product.

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Abstract

The invention discloses sodium aescinate toothpaste and relates to the technical field of daily chemical products. The toothpaste disclosed by the invention comprises the following components in percentage by weight: 0.05%-2% of sodium aescinate, 20-55% of a friction agent, 20-30% of a moisturizing agent, 2-3% of a surfactant, 1-2% of a thickening agent, 0.05-0.25% of a sweetener, 0.05-0.5% of a preservative, 1-2% of essence, other special ingredients and the balance of water, and sodium aescinate toothpaste is prepared from the components by one of an intermittent two-step paste making method, a dry process one-step paste making method and a wet process one-step paste making method. The toothpaste disclosed by the invention has anti-inflammatory, detumescent and anti-exudation effects, and can be used for improving micro-circulation, promoting dissolution and absorption of hematoma, and well preventing and treating bleeding, swelling and halitosis caused by gum swelling and pain; and the toothpaste does not pass through a gastrointestinal tract and blood circulation, so that adverse reactions can be avoided and safety is realized.

Description

technical field [0001] The invention relates to the technical field of daily chemicals, in particular to a sodium aescinate toothpaste and a preparation method thereof. Background technique [0002] Sodium aescinate is the sodium salt of triterpenoid saponin extracted from the dried and mature fruit of the traditional Chinese medicine Suluozi. At present, it is mostly used in clinical practice as total sodium aescinin, which mainly contains 4 components. my country's national standards are named as sodium aescinate A, sodium aescinin B, sodium aescinin C and sodium aescinate D in sequence according to the liquid chromatography peak. Wherein the chemical structural formulas of sodium aescinate A and sodium aescinate B are as follows: [0003] [0004] Sodium Aescinate A:R1:-CH 3 R2:-H; Aescin Sodium B: R1:-H R2:-CH 3 [0005] Studies have found that sodium aescinate can reduce vascular permeability, have obvious inhibitory effect on lysosomal activity in serum, stabi...

Claims

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Application Information

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IPC IPC(8): A61K8/63A61K8/73A61Q11/00A61P1/02
Inventor 吴晓华孟书舫游奶寿
Owner FUJIAN MINDONG REJUVENATION PHARMA
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