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Compound sodium aescinate cataplasm

A technology of compound aescin and sodium aescinate, which is applied in the directions of pharmaceutical formula, flake delivery, organic active ingredients, etc., can solve the problems that there is no compound escinate sodium cataplasm, and improve the therapeutic effect and load The effect of large dose and small side effects

Inactive Publication Date: 2011-05-11
CHONGQING PHARMA RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far there is no compound aescin sodium cataplasm and related reports

Method used

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  • Compound sodium aescinate cataplasm
  • Compound sodium aescinate cataplasm
  • Compound sodium aescinate cataplasm

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Compound sodium aescinate cataplasm, main ingredient content (0.5%)

[0052] prescription:

[0053]

[0054] Preparation:

[0055] a. Dissolve methylparaben and vitamin C in azone, then disperse aluminum glyoxate and EDTA through a 200-mesh sieve in azone, then add the mixture of ground titanium dioxide, talcum powder and glycerin, get the oily phase;

[0056] b. Physically mix NP700, sodium carboxymethylcellulose, and polyvinylpyrrolidone, and disperse them into the oil phase of step a;

[0057] c. tartaric acid is dissolved in 240 grams of water and becomes a solution for subsequent use;

[0058] d. Dissolve gelatin in water at 1:10, swell for 15 minutes at 40°C, dissolve the main ingredients (sodium aescinate and diethylamine salicylate) with the remaining water, and then put the gelatin and the main ingredients at 30°C Add to the oil phase of step b under the condition, then add the solution of step c in 6 times, and stir for 30 minutes to obtain the paste; ...

Embodiment 2

[0061] Preparation of compound sodium aescinate cataplasm, main ingredient content (1%)

[0062] prescription:

[0063]

[0064] Preparation:

[0065] a. Dissolve methylparaben in azone and propylene glycol, then disperse aluminum glyoxate and EDTA-2Na through a 200 mesh sieve, then add the mixture of ground titanium dioxide, zinc oxide and glycerin to obtain oil phase;

[0066] b. Physically mix sodium polyacrylate, sodium carboxymethyl cellulose, and gum tragacanth, and disperse them in the oil phase of step a;

[0067] c. tartaric acid is dissolved in 240 grams of water and becomes a solution for subsequent use;

[0068] d. Dissolve the main ingredients (sodium aescinate and diethylamine salicylate) with the remaining water, then add to the oil phase of step b, then add the solution of step c in 6 times, and stir for 30 minutes to obtain a paste body;

[0069] e. Spread the paste in step d on the non-woven fabric, cover with release paper, cut into 120 pieces, and p...

Embodiment 3

[0071] Preparation of compound sodium aescinate cataplasm, main ingredient content (4%)

[0072] prescription

[0073]

[0074]

[0075] Preparation:

[0076] a. Mix azone and propylene glycol, then disperse aluminum hydroxide and EDTA-2Na passing through a 200-mesh sieve, and then add the mixture of ground kaolin and glycerin to obtain an oil phase;

[0077] b. Physically mix sodium polyacrylate, sodium carboxymethyl cellulose, and gum tragacanth, and disperse them in the oil phase of step a;

[0078] c. citric acid is dissolved in 240 grams of water and becomes a solution for subsequent use;

[0079] d. Dissolve the main ingredients (sodium aescinate and diethylamine salicylate) and sodium bisulfite with the remaining water, then add to the oil phase of step b, then add the solution of step c in 6 times, and stir for 30 Minutes to get the paste;

[0080] e. Spread the paste in step d on the non-woven fabric, cover with release paper, cut into 120 pieces, and pack t...

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Abstract

The invention relates to a compound sodium aescinate cataplasm, which comprises an outer lining layer, a medicament tank and a protective layer, wherein the medicament tank layer comprises sodium aescinate, diethylamine salicylate, a framework material, a tackifier, a humectants, a penetration enhancer, a cross-linking agent, a cross-linking regulator, a pH value regulator, A preservative, a spice, a filler, water, antioxygen and the like. The compound sodium aescinate cataplasm can carry a large amount of medicament, has high moisturizing performance and breathability, is convenient to use, can improve treatment effect and is free from side effects such as sensitization.

Description

technical field [0001] The present invention relates to the field of pharmaceutical preparations, in particular to a compound sodium aescinate cataplasm and a preparation method thereof. The cataplasm comprises aescin or its sodium salt and diethylamine salicylate, a cataplasm base, Wherein, the weight ratio of sodium aescinate to diethylamine salicylate is 1:1-10. The cataplasm is used for the treatment of contusions, sprains, crush injuries and hematomas, painful spinal diseases (intervertebral disc injuries, stiff neck, low back pain, sciatica) and tenosynovitis. Background technique [0002] Compound sodium aescinate is a compound composed of sodium aescinate and diethylamine salicylate. At present, the compound sodium aescinate gel has been listed in the domestic market, mainly used for the treatment of contusions, sprains, crush injuries and hematomas, painful spinal diseases (intervertebral disc injury, neck stiffness, lumbago, sciatica) and tenosynovitis, etc. Supe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K31/60A61K9/70A61P21/00A61P19/08
Inventor 丁彦吉张涛邓杰樊斌
Owner CHONGQING PHARMA RES INST
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