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Phenolic extract of stevia rebaudiana and application of phenolic extract in anti-inflammatory products

A steviol phenol and extract technology, which is applied to steviol phenol extract and its application in anti-inflammatory products, can solve problems such as environmental pollution and resource waste, achieve broad development and application prospects, and reduce NO content. , the effect of easy industrialization

Active Publication Date: 2016-12-21
CHENGUANG BIOTECH GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Stevia phenols exist as impurities in the production process of steviol glycosides, which need to be removed in the subsequent process, which not only causes waste of resources, but also causes great pollution to the environment

Method used

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  • Phenolic extract of stevia rebaudiana and application of phenolic extract in anti-inflammatory products
  • Phenolic extract of stevia rebaudiana and application of phenolic extract in anti-inflammatory products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] This example provides an in vitro anti-inflammatory effect experiment of stevia phenolic extracts.

[0027] 1.1 Experimental materials

[0028] 1.1.1 Reagents and instruments

[0029] Stevia phenolic extract; lipopolysaccharide (LPS), Sigma Company of the United States; chlorogenic acid, Chengdu Master Biotechnology Co., Ltd.; NO, CCK-8 kit, Biyuntian Biotechnology Research Institute; mouse feed (carbohydrate 64% compound, 21% protein, 4% fat, 5% fiber), Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.; other reagents are domestic analytical grade; SIGMA3K15 desktop centrifuge, Beijing Wuzhou East Science and Technology Development Co., Ltd.; HH -4 digital constant temperature water bath, Ronghua Instrument Manufacturing Co., Ltd., Jintan City, Jiangsu Province; Axiovert 200 inverted microscope, Zeiss, Germany; Galaxy S CO 2 Incubator, RS Biotech, UK.

[0030] 1.1.2 Animals

[0031] SPF grade Balb / c male mice (6-8 weeks old), Beijing Weitong Lihua Expe...

Embodiment 2

[0041] This example provides an experiment on the anti-inflammatory effect of stevia phenolic extracts in vivo.

[0042] 2.1 Experimental materials

[0043] 2.1.1 Reagents and instruments

[0044] Stevia phenolic extract; carrageenan, Shanghai Jianglai Biotechnology Co., Ltd.; dexamethasone, MYM Biotechnology Co., Ltd.; NO, CCK-8 kit, Biyuntian Biotechnology Research Institute; mouse feed (carbohydrate Compound 64%, protein 21%, fat 4%, fiber 5%), Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.; other reagents are domestic analytical grade; HH-4 digital constant temperature water bath, Jintan City, Jiangsu Province Ronghua Instrument Manufacturing Co., Ltd.; Axiovert 200 inverted microscope, Zeiss, Germany.

[0045] 2.1.2 Animals

[0046] SPF grade ICR male mice (18-22g), Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., license number: SCXK (Beijing) 2012-0001. During the experiment, the animals were kept at a temperature of 21±2°C, a relative...

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Abstract

The invention discloses a phenolic extract of stevia rebaudiana and application of the phenolic extract in anti-inflammatory products, and belongs to the technical field of plant extracts. Main components of the phenolic extract of stevia rebaudiana disclosed by the invention are chlorogenic acid and flavonoid compounds. The phenolic extract of stevia rebaudiana can significantly inhibit xylene-induced ear swelling and carrageenin-induced paw swelling, inhibit LPS-induced macrophage NO release, can decrease the content of inflammatory factor NO in serum, and has good anti-inflammatory activity; the phenolic extract of stevia rebaudiana provided by the invention has advantages of rich source of raw materials, easy industrialization, no toxic or side effect and the like, and has broad development and application prospects as anti-inflammatory products.

Description

technical field [0001] The invention belongs to the technical field of plant extracts, and relates to a stevia phenolic extract and its application in anti-inflammatory products. Background technique [0002] Stevia rebaudiana (Stevia rebaudiana) is a perennial herb of the Asteraceae family, native to Paraguay and Brazil in South America. It is one of the known sugar plants with high sweetness and has become the third natural sugar after sucrose and beet sugar. source. At present, China is the world's largest producer and supplier of steviol glycosides, accounting for more than 80% of the global total. In addition to steviol glycosides, Stevia contains flavonoids, chlorogenic acid and other components, and these components have important biological activities, such as antibacterial, lowering blood pressure, lowering blood lipids, etc. It has been used as sweet tea and herbal tea in its birthplace. More than one hundred years of history. [0003] Steviol glycosides are mos...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61P29/00A23L33/105
CPCA23V2002/00A61K36/28A61K2236/331A61K2236/39A61K2236/53A61K2236/55A23V2200/30A23V2250/028A23V2250/2116A23V2250/2132A23V2300/10A23V2300/14A23V2300/34A23V2300/50
Inventor 徐美利赵磊杨香瑜安晓东李乾丽连运河王成涛
Owner CHENGUANG BIOTECH GRP CO LTD
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