62results about How to "Good for persistence" patented technology

The invention provides a drug-oligomer conjugate having the following general formula:wherein D is a therapeutic drug moiety; H and H' are each a hydrophilic moiety, independently selected from the group consisting of straight or branched PEG polymers having from 2 to 130 PEG subunits, and sugars; L is a lipophilic moiety selected from the group consisting of alkyl groups having 2-26 carbon atoms, cholesterol, adamantane and fatty acids; o is a number from 1 to the maximum number of covalent bonding sites on H; m+n+p together have a value of at least one and not exceeding the total number of covalent bonding sites on D for the -H', -L and -H-L substituents; the H-L bond(s) are hydrolyzable and the D-L' bond(s), when present, are hydrolyzable; the conjugate being further characterized by one of the following: (i) m is 0 and p is at least 1; (ii) n is 0 and p is at least 1; (iii) m and n are each 0 and p is at least 1; (iv) p is 0 and m and n are each at least 1. The therapeutic drug moiety is preferably a therapeutic protein or peptide, preferably insulin or a functional equivalent thereof.

The invention relates to a medical waste management weight verification method. The method performs weight management on medical wastes from a generation point to a final disposal point through relay nodes at various levels, weighs the medical wastes at the generation point, pastes a waste information Label, uploads initial weight information to a cloud management platform, reweighs the medical wastes during in-warehouse and out-warehouse processes at the relay points and the disposal points, and enables the cloud management platform match and verify the weight and the initial weight of the medical wastes. The method controls the entire life cycle of the medical wastes from generation to disposal, performs weight control and repeated verification in the whole process of production, storage, transportation and disposal so as to prevent leaks, enhance the safety of a closed-loop system, and eliminates opportunities for criminals to take advantage.

Disclosed herein is a method for preparing a liquid chemical for forming a water-repellent protective film, the liquid chemical being for forming the water-repellent protective film at the time of cleaning a wafer having at its surface an uneven pattern and containing silicon element at least at a part of the uneven pattern at least on surfaces of recessed portions of the uneven pattern, the liquid chemical containing a nonaqueous organic solvent, a silylation agent, and an acid or a base. The method includes (i) adjusting a water content of the nonaqueous organic solvent to 200 mass ppm or less by dehydration; and (ii) mixing the nonaqueous organic solvent, the silylation agent, and the acid or the base after the adjusting step.

The present invention provides resin beads that are capable of realizing a water repellent and oil repellent effect, and further, that are also capable of providing cosmetic materials excellent in persistence of makeup when added and used in cosmetic materials etc. because the resin beads themselves contain silicone in a fixed state, and the present invention also provides a process for producing the resin beads. Resin beads being resin particles (a copolymer) obtained by subjecting a monomer mixture containing a plurality of monomers each having a copolymerizable functional group to suspension polymerization in a state where at least a non-polymerizable silicone is present, the resin particles containing the silicon in a fixed state, and a process for producing the resin beads.

The present invention provides resin beads that are capable of imparting stable water repellency and oil absorbency at a high level to products, and realizing good spreadability and excellent persistence of makeup without giving sticky feeling when added to, for example, cosmetic materials, the process for producing the resin beads, and various kinds of products using the resin beads and having excellent properties. Resin beads being resin particles obtained by subjecting a monomer mixture containing a plurality of monomers each having a copolymerizable functional group to suspension polymerization in a state where at least a non-polymerizable silicone compound is present, the resin particles each having a roughened surface, and a process for producing the resin beads, and various kinds of products each using the resin beads and each having excellent properties.

Provided are a Gemini-type alkyl-polyoxyalkylene-modified silicone suitable for use in preparing a silicone emulsion; a production method of thereof; and a defoaming agent composition containing such Gemini-type alkyl-polyoxyalkylene-modified silicone.The Gemini-type alkyl-polyoxyalkylene-modified silicone is expressed by the following general formula (A):wherein each of R1, R2, R3, R4, R5 and R6 represents an alkyl group or the like; n represents an integer of 0 to 300; and (B) represents a group expressed by the following general formula (1) or general formula (2):wherein each of R7 and X represents a hydrocarbon group; R8 represents a hydrogen atom, a hydrocarbon group, a formyl group or an acyl group; and a and b represent numbers satisfying 2≦a≦200 and 0≦b≦200, provided that a+b=2 to 200.

An antifogging article having a high antifogging property and being excellent in persistence of the antifogging property is provided. The antifogging article having a substrate and a water absorbing layer on a surface of at least a part of the substrate, wherein the water absorbing layer comprises a cured epoxy resin as a main body, obtained by reacting a polyepoxide and a curing agent, and a surfactant having an HLB within a range of 6 to 18, the HLB being calculated by a Griffin method.

[Problem] To provide a method for preparing a protective film-forming liquid chemical, in a method for producing a wafer having at its surface an uneven pattern and containing silicon element at least at a part of the uneven pattern. The liquid chemical forms a water-repellent protective film on the uneven pattern of the wafer and improves a cleaning step which tends to induce a pattern collapse, and particularly provides a good persistence (pot life) of the improving effect.[Solution] A method for preparing a liquid chemical for forming a water-repellent protective film, the liquid chemical being for forming a water-repellent protective film at the time of cleaning the wafer at least on surfaces of recessed portions of the uneven pattern, the liquid chemical containing a nonaqueous organic solvent, a silylation agent, and an acid or base. The method for preparing a liquid chemical for forming a water-repellent protective film is characterized by including:a dehydrating step for adjusting a water content of the nonaqueous organic solvent to 200 mass ppm or less; anda mixing step for mixing the nonaqueous organic solvent, the silylation agent, and the acid or base after the dehydrating step.

An object of the present invention is to provide a method of fixing an antibacterial agent, by which method it is possible to impart articles of a wide range of materials with excellent antibacterial property and good persistence of antibacterial activity. Specifically, the method of fixing an antibacterial agent, comprises the steps of:subjecting a surface of an article to a surface treatment of providing the surface with oxygen-containing functional groups; and thensubjecting the article to a treatment using an antibacterial agent composition including a silicon-containing compound (a) represented by general formula (1) below.wherein R1 represents a hydrocarbon group having 6 or more carbon atoms, R2 and R3 represent lower hydrocarbon groups, respectively, which hydrocarbon groups may be the same or different from each other, R4 represents a divalent lower hydrocarbon group, R5, R6 and R7 represent lower alkyl groups or lower alkoxy groups, respectively, which may be the same or different from each other, and X represents a halogen ion or an organic carbonyloxy ion, or alternatively, first treating the article by using the antibacterial agent composition; and then subjecting the article to a 1-10 GHz microwave irradiation treatment in a state where the antibacterial agent composition remains on the surface of the article.

The present invention relates to the use, as active ingredient, of a 1-N-(halo-3-pyridylmethyl)-N-methylamino-1-alkylamino-2-nitroethylene derivative for preparing a veterinary pharmaceutical composition for topical use in the treatment of external parasites, in particular fleas, in domestic animals, in particular in dogs and cats, intended to be applied at least every 2 weeks.

Provided is a dentifrice composition containing erythritol, which is excellent in storage stability and the persistence of a cool feeling and gives a higher refreshing feeling. The dentifrice composition comprises: (A) 15 to 50 weight % of erythritol having a particle size of less than 355 μm; (B) 10 to 40 weight % of water; and (C) 0.6 to 3 weight % of a binder.

Embodiments of the disclosure include methods and compositions for producing NKT cells effective for immunotherapy and also methods and compositions for providing an effective amount of NKT cells to an individual in need of immunotherapy. In specific embodiments, the NKT cells are CD62L+ and have been exposed to one or more costimulatory agents to maintain CD62L expression. The NKT cells may be modified to incorporate a chimeric antigen receptor, in some cases.

A method of over-seeding dormant warm season grasses, including over-seeding the warm season grass with Turf Type Festulolium (American Ryegrass) such that the American Ryegrass will provide a green cover during the winter months but will die out when the temperatures increase to the point which allow the warm-season grass to regrow. A method maintain green coverage of turf year-round including planting a warm season grass, and over-seeding the warm season grass with American Ryegrass. The method where the American Ryegrass is selected from the group consisting of breeder's codes: APMT001, APMT002, APMT003, APMT004, APMT005, APMT006, APMT007, APMT008, APMT009, APMT010, and APMT011.

The present invention relates to a filler composition for tissue reinforcement, including hyaluronic acid and alkylene diamine crosslinked hydrogel. The filler composition exhibits the positive physical properties required for tissue reinforcement, such as biocompatibility and swelling ability, as well as useful effects in that the same can remain in vivo for a long time.

Disclosed is a pest repellent that has excellent heat resistance and solvent resistance, that can be kneaded into a resin molded article or a synthetic fiber, and that has excellent durability and persistence for which a pest repellent effect is sustained for a long period even when it is used for a long period or washed. A durable pest repellent that has both high heat resistance and persistence has been accomplished by supporting on a specific layered silicate a pest repellent chemical containing as an essential component at least one selected from N,N-diethyl-m-toluamide, 1-piperidinecarboxylic acid-2-(2-hydroxyethyl)-1-methylpropyl ester, and N,N-diethyl-m-toluamide and 1-piperidinecarboxylic acid-2-(2-hydroxyethyl)-1-methylpropyl ester.

A dip-forming composition of the present invention comprises a dip-forming latex containing a copolymer obtained by copolymerizing 100 parts by weight of a monomer mixture containing 70 to 85 parts by weight of a conjugated diene monomer, 10 to 28 parts by weight of an aromatic vinyl monomer, 2 to 5 parts by weight of an ethylenically unsaturated acid monomer and 0 to 18 parts by weight of other monomer copolymerizable with these monomers, said copolymer having a toluene insoluble content of 30% by weight or more and a toluene swelling degree of 70 times or less; and a vulcanizing agent, a vulcanization accelerator and zinc oxide which are blended in said latex in amounts of 0.5 to 2 parts by weight, 0.25 to 1 part by weight and 0.5 to 1 part by weight, respectively, on the basis of 100 parts by weight of a solid content of the latex. There can be provided a dip-formed article exhibiting an excellent touch and feel, sufficient tensile strength and elongation at break and an excellent persistence of close fitting, as well as a dip-forming composition capable of providing such a dip-formed article.

An object of the present invention is to provide a method of fixing an antibacterial agent, by which method it is possible to impart articles of a wide range of materials with excellent antibacterial property and good persistence of antibacterial activity. Specifically, the method of fixing an antibacterial agent, comprises the steps of:subjecting a surface of an article to a surface treatment of providing the surface with oxygen-containing functional groups; and thensubjecting the article to a treatment using an antibacterial agent composition including a silicon-containing compound (a) represented by general formula (1) below.wherein R1 represents a hydrocarbon group having 6 or more carbon atoms, R2 and R3 represent lower hydrocarbon groups, respectively, which hydrocarbon groups may be the same or different from each other, R4 represents a divalent lower hydrocarbon group, R5, R6 and R7 represent lower alkyl groups or lower alkoxy groups, respectively, which may be the same or different from each other, and X represents a halogen ion or an organic carbonyloxy ion, or alternatively, first treating the article by using the antibacterial agent composition; and then subjecting the article to a 1-10 GHz microwave irradiation treatment in a state where the antibacterial agent composition remains on the surface of the article.