Method and Composition for Potentiating the Antipyretic Action of a Nonopiod Analgesic
a nonopioid analgesic and antipyretic technology, applied in the direction of drug compositions, biocide, amide active ingredients, etc., can solve the problems of lack of antiinflammatory and anticoagulatory properties of other nonsteroidal antiinflammatory drugs, and achieve the effects of potentiating the antipyretic action, reducing or eliminating various adverse effects associated with fever
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[0020]The present invention is directed to the simultaneous or sequential administration of a nonopioid analgesic and an endothelin antagonist to potentiate the antipyretic action of the nonopioid analgesic and to treat pain. In particular, the administration of a nonopioid analgesic and an endothelin antagonist potentiates the antipyretic action of the nonopioid analgesic, without adversely affecting the analgesic properties of the analgesic.
[0021]The present invention, therefore, provides compositions and methods of potentiating the anti-pyretic action of a nonopioid analgesic, while maintaining analgesic action. The present invention also provides pharmaceutical compositions comprising a nonopioid analgesic and an endothelin antagonist. Further provided are articles of manufacture comprising a nonopioid analgesic and an endothelin antagonist, packaged separately or together, and an insert having instructions for using these active agents.
[0022]The methods described herein benefit...
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