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Method and Composition for Potentiating the Antipyretic Action of a Nonopiod Analgesic

a nonopioid analgesic and antipyretic technology, applied in the direction of drug compositions, biocide, amide active ingredients, etc., can solve the problems of lack of antiinflammatory and anticoagulatory properties of other nonsteroidal antiinflammatory drugs, and achieve the effects of potentiating the antipyretic action, reducing or eliminating various adverse effects associated with fever

Inactive Publication Date: 2008-08-28
UNIV OF ILLINOIS CHICAGO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This combination significantly potentiates the antipyretic action of nonopioid analgesics, providing enhanced fever reduction while maintaining the analgesic effect, as demonstrated by increased duration and intensity of hypothermic responses without affecting analgesic activity.

Problems solved by technology

Acetaminophen is an antipyretic and analgesic, but it lacks the antiinflammatory and anticoagulatory properties of other nonsteroidal antiinflammatory drugs (NSAIDs).

Method used

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  • Method and Composition for Potentiating the Antipyretic Action of a Nonopiod Analgesic

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Embodiment Construction

[0020]The present invention is directed to the simultaneous or sequential administration of a nonopioid analgesic and an endothelin antagonist to potentiate the antipyretic action of the nonopioid analgesic and to treat pain. In particular, the administration of a nonopioid analgesic and an endothelin antagonist potentiates the antipyretic action of the nonopioid analgesic, without adversely affecting the analgesic properties of the analgesic.

[0021]The present invention, therefore, provides compositions and methods of potentiating the anti-pyretic action of a nonopioid analgesic, while maintaining analgesic action. The present invention also provides pharmaceutical compositions comprising a nonopioid analgesic and an endothelin antagonist. Further provided are articles of manufacture comprising a nonopioid analgesic and an endothelin antagonist, packaged separately or together, and an insert having instructions for using these active agents.

[0022]The methods described herein benefit...

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Abstract

A composition and method of treating fever, and optionally treating pain, is disclosed. The composition and method utilize a nonopioid analgesic and an endothelin antagonist as active agents to treat fever in mammals, including humans. The composition also is useful in the prevention and treatment of stroke and other cardiovascular disorders, like myocardial infarction.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application claims the benefit of U.S. provisional patent application Ser. No. 60 / 390,045, filed Jun. 19, 2002.FIELD OF THE INVENTION[0002]The present invention relates to the treatment of fever using a nonopioid analgesic and an endothelin antagonist. More particularly, the present invention relates to a method of potentiating the antipyretic action of a nonopioid analgesic, like acetaminophen, in a mammal by administration of a therapeutically effective amount of an endothelin antagonist. The composition and method potentiate the antipyretic action of the nonopioid analgesic, without adversely effecting the analgesic action of the nonopioid analgesic.BACKGROUND OF THE INVENTION[0003]Fever is one of the most common conditions requiring an individual to seek medical attention. In addition to treating the cause of the fever, medical personnel treat, i.e., reduce, the fever itself using analgesics, antipyretics, and / or physical cooling...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/167A61P25/00A61K31/192A61K31/415A61K31/60A61K45/06A61P29/00
CPCA61K31/192A61K31/415A61K31/60A61K45/06A61K2300/00A61P25/00A61P29/00
Inventor GULATI, ANIL
Owner UNIV OF ILLINOIS CHICAGO
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