Antibacterial acellular dermal dressing with vascularization inducing capability and preparation method thereof

Abstract

The invention belongs to the technical field of biomedical engineering, in particular relates to the technical field of skin wound dressing preparation, and discloses an antibacterial acellular dermal dressing with vascularization inducing capability and a preparation method thereof. The antibacterial acellular dermal matrix dressing comprises porcine acellular dermal matrix, poly dopamine, vascular endothelial growth factor (VEGF) composition and antibacterial peptide LL37. The antibacterial acellular dermal dressing with the vascularization inducing capability has the advantages of low immunogenicity, good biocompatibility and antibacterial ability, and has obvious wound healing and vascularization promoting effect.

Description

technical field [0001] The invention belongs to the technical field of biomedical engineering, in particular to the technical field of skin wound dressing preparation, and discloses an antibacterial acellular dermal dressing capable of inducing vascularization and a preparation method thereof. Background technique [0002] With the progress of research on the treatment of skin damage, tissue engineered skin has become a research hotspot in recent years and has broad clinical application prospects. When the skin is faced with a large area of ​​burn or damage, it urgently needs to obtain a large amount of epidermal coverage to promote the regeneration and repair of skin tissue. Acellular dermal matrix has many advantages as an ideal skin repair material: (1) cheap and widely sourced; (2) good tissue compatibility, non-toxic and low antigenicity; (3) degradable, The material is gradually absorbed during the degradation process and maintains a stable volume; (4) maintains the c...

AI Technical Summary

Problems solved by technology

However, since the acellular dermal matrix is ​​an inactive scaffold material, the vascularization ability is low in use, especially the heterogeneous acellular dermal matrix, another problem encountered in clinical application is how to solve the problem of large tissue or organ implantation The source of nutrition in the body. Obviously, it is impossible to achieve the survival of a large number of living cells in the body without a blood supply. How to solve the problem of insufficient vascularization of the acellular dermal matrix in the application is a breakthrough in the acellular dermal matrix. The key to the bottleneck of clinical application of matrix

In addition, the acellular dermal matrix has no antibacterial ability, and when used as a dressing, it is easily infected by bacteria and causes wound infection, and has the risk of cross infection, which also limits its clinical application as a dressing.

Images