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A kind of 3D bionic skin dressing and preparation method thereof

A skin and 3D technology, applied in bandages, textiles, papermaking, absorbent pads, etc., can solve the problems of common dressings such as susceptibility to infection, poor permeability, and complicated operations, achieve important academic value and application prospects, reduce the number of replacements, and promote The effect of blood vessel growth

Active Publication Date: 2022-02-15
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Based on the deficiencies of the prior art described above, the purpose of the present invention is to provide a 3D bionic skin dressing and its preparation method, which are used to solve the problems of the existing common dressings that are susceptible to infection, low in efficiency, poor in permeability, and complicated in operation

Method used

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  • A kind of 3D bionic skin dressing and preparation method thereof
  • A kind of 3D bionic skin dressing and preparation method thereof

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Embodiment 1

[0041]A method for preparing a 3D bionic skin dressing, characterized in that the dressing comprises a hydrophilic layer fibrous membrane and a hydrophobic layer fibrous membrane, the hydrophilic membrane is loaded with living biologically active substances that promote the growth of blood vessel inner wall tissue, and the hydrophobic layer dressing is loaded with antibacterial substances; Bionic hair follicles with different pore sizes are distributed on the hydrophilic-hydrophobic double-layer dressing, and hydrogel is filled in the pores of the hair follicles.

[0042] The preparation method of a 3D bionic skin dressing of the present invention will be described in detail below in conjunction with the specific drawings.

[0043] First, the material of the hydrophilic layer fiber membrane is selected as polycaprolactone (PCL), and the biologically active substances loaded on the hydrophilic membrane to promote the growth of blood vessel inner wall tissue can be: VEGF and Angi...

Embodiment 2

[0049] A 3D bionic skin dressing, characterized in that it includes interconnected hydrophilic layer fibrous membranes 1 and hydrophobic layer fibrous membranes 2, the hydrophilic layer fibrous membranes are loaded with biologically active substances 11, which can promote the growth of blood vessel inner wall tissue, so The hydrophobic layer fiber membrane is loaded with antibacterial substances 21, the surface of the hydrophilic layer fiber membrane and the surface of the hydrophobic layer fiber membrane are all provided with a bionic hair follicle layer 3, and the bionic hair follicle layer includes symmetrically arranged hair follicle holes 31, and the hair follicle holes The hair follicle pores are filled with a hydrogel layer 4 through the hydrophilic layer fiber membrane and the hydrophobic layer fiber membrane.

[0050] Further, the hydrophilic layer fiber membrane is made of polycaprolactone (PCL).

[0051] Further, the biologically active substance is a combination of...

Embodiment 3

[0071] A 3D bionic skin dressing, characterized in that it includes interconnected hydrophilic layer fibrous membranes 1 and hydrophobic layer fibrous membranes 2, the hydrophilic layer fibrous membranes are loaded with biologically active substances 11, which can promote the growth of blood vessel inner wall tissue, so The hydrophobic layer fiber membrane is loaded with antibacterial substances 21, the surface of the hydrophilic layer fiber membrane and the surface of the hydrophobic layer fiber membrane are all provided with a bionic hair follicle layer 3, and the bionic hair follicle layer includes symmetrically arranged hair follicle holes 31, and the hair follicle holes The hair follicle pores are filled with a hydrogel layer 4 through the hydrophilic layer fiber membrane and the hydrophobic layer fiber membrane.

[0072] Further, the hydrophilic layer fiber membrane is made of polycaprolactone-polyvinyl alcohol blend (PCL-PVA).

[0073] Further, the bioactive substance i...

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Abstract

The invention provides a 3D bionic skin dressing and a preparation method thereof, comprising interconnected hydrophilic layer fiber membranes and hydrophobic layer fiber membranes, the hydrophilic layer fiber membranes are loaded with biologically active substances, and the hydrophobic layer fiber membranes are loaded with Antibacterial substance, the surface of the hydrophilic layer fiber membrane and the surface of the hydrophobic layer fiber membrane are provided with a bionic hair follicle layer, the bionic hair follicle layer includes symmetrically arranged hair follicle holes, the hair follicle holes run through the hydrophilic layer fiber membrane, hydrophobic A layer of fibrous membrane, the pores of the hair follicle are filled with a hydrogel layer. The invention provides an efficient dressing for the treatment of burn wounds, promotes the development of the theory and application of 3D bionic skin dressings in the treatment of burn wounds, provides new ideas and approaches, and has important academic value and application prospects.

Description

technical field [0001] The invention belongs to the field of micro-nano manufacturing, and relates to a 3D bionic skin dressing and a preparation method thereof, in particular to a preparation method of a bionic skin dressing that simulates the structural characteristics of natural skin epidermis-dermis. Background technique [0002] Currently, there are two main treatments for burn wounds: tissue engineered skin to replace original tissue and wound dressing to promote repair of damaged tissue. Natural skin is considered the perfect "wound dressing" and an ideal wound dressing should replicate the characteristics of natural skin as closely as possible. The natural skin has two barrier functions: on the one hand, it prevents the loss of water, electrolytes and other substances in the body; on the other hand, it prevents the invasion of harmful substances from the outside. The skin maintains the stability of the internal environment of the human body, and also participates in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/26A61L15/32A61L15/44A61L15/46A61L15/42D04H1/435D04H1/4382D04H1/728B33Y70/00B33Y80/00
CPCA61L15/26A61L15/28A61L15/32A61L15/44A61L15/46A61L15/42D04H1/435D04H1/4382D04H1/728B33Y70/00B33Y80/00A61L2300/414A61L2300/252A61L2300/404C08L67/04C08L5/08C08L89/00
Inventor 袁志山孙秋梦王成勇曾胜易新
Owner GUANGDONG UNIV OF TECH
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