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Novel 3D bionic skin dressing and preparation method thereof

A 3D, skin technology, applied in the field of micro-nano manufacturing, can solve the problems of easy infection, poor permeability and complicated operation of ordinary dressings, and achieve the effect of preventing the loss of body fluids and nutrients, reducing the number of replacements, and promoting the growth of blood vessels.

Active Publication Date: 2021-01-08
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Based on the deficiencies of the prior art described above, the purpose of the present invention is to provide a novel 3D bionic skin dressing and its preparation method, which are used to solve the problems of the existing common dressings that are susceptible to infection, low in efficiency, poor in permeability, and complicated in operation

Method used

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  • Novel 3D bionic skin dressing and preparation method thereof
  • Novel 3D bionic skin dressing and preparation method thereof

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Effect test

Embodiment 1

[0041] A preparation method of a novel 3D bionic skin dressing, characterized in that the dressing comprises a hydrophilic layer fibrous membrane and a hydrophobic layer fibrous membrane, the hydrophilic membrane is loaded with live bioactive substances that promote the growth of blood vessel inner wall tissue, and the hydrophobic layer dressing is loaded with antibacterial substances ; Bionic hair follicles with different pore sizes are distributed on the hydrophilic-hydrophobic double-layer dressing, and the hydrogel is filled in the pores of the hair follicles.

[0042] The preparation method of a novel 3D bionic skin dressing of the present invention will be described in detail below in conjunction with specific drawings.

[0043] First, the material of the hydrophilic layer fiber membrane is selected as polycaprolactone (PCL), and the biologically active substances loaded on the hydrophilic membrane to promote the growth of blood vessel inner wall tissue can be: VEGF and A...

Embodiment 2

[0049] A novel 3D bionic skin dressing, characterized in that it includes interconnected hydrophilic layer fibrous membrane 1 and hydrophobic layer fibrous membrane 2, the hydrophilic layer fibrous membrane is loaded with biologically active substances 11, which can promote the growth of blood vessel inner wall tissue, The hydrophobic layer fiber membrane is loaded with antibacterial substances 21, the surface of the hydrophilic layer fiber membrane and the surface of the hydrophobic layer fiber membrane are all provided with a bionic hair follicle layer 3, and the bionic hair follicle layer includes symmetrically arranged hair follicle holes 31, and the hair follicle The pores run through the hydrophilic layer fiber membrane and the hydrophobic layer fiber membrane, and the hair follicle pores are filled with a hydrogel layer 4 .

[0050] Further, the hydrophilic layer fiber membrane is made of polycaprolactone (PCL).

[0051] Further, the biologically active substance is a c...

Embodiment 3

[0071] A novel 3D bionic skin dressing, characterized in that it includes interconnected hydrophilic layer fibrous membrane 1 and hydrophobic layer fibrous membrane 2, the hydrophilic layer fibrous membrane is loaded with biologically active substances 11, which can promote the growth of blood vessel inner wall tissue, The hydrophobic layer fiber membrane is loaded with antibacterial substances 21, the surface of the hydrophilic layer fiber membrane and the surface of the hydrophobic layer fiber membrane are all provided with a bionic hair follicle layer 3, and the bionic hair follicle layer includes symmetrically arranged hair follicle holes 31, and the hair follicle The pores run through the hydrophilic layer fiber membrane and the hydrophobic layer fiber membrane, and the hair follicle pores are filled with a hydrogel layer 4 .

[0072] Further, the hydrophilic layer fiber membrane is made of polycaprolactone-polyvinyl alcohol blend (PCL-PVA).

[0073] Further, the bioactiv...

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Abstract

The invention provides a novel 3D bionic skin dressing and a preparation method thereof. The novel 3D bionic skin dressing comprises a hydrophilic layer fibrous membrane and a hydrophobic layer fibrous membrane which are connected with each other, wherein the hydrophilic layer fibrous membrane is loaded with a bioactive substance, the hydrophobic layer fibrous membrane is loaded with an antibacterial substance, the surface of the hydrophilic layer fibrous membrane and the surface of the hydrophobic layer fibrous membrane are each provided with a bionic hair follicle layer, each bionic hair follicle layer comprises hair follicle holes which are symmetrically arranged, the hair follicle holes penetrate through the hydrophilic layer fiber membrane and the hydrophobic layer fiber membrane, andthe hair follicle holes are filled with hydrogel layers. The novel efficient dressing is provided for the treatment of burn wounds, the theoretical and application development of the 3D bionic skin dressing in promoting burn wound treatment is promoted, a new thought and approach are provided, and important academic values and application prospects are achieved.

Description

technical field [0001] The invention belongs to the field of micro-nano manufacturing, and relates to a novel 3D bionic skin dressing and a preparation method thereof, in particular to a preparation method of a bionic skin dressing that simulates the structural characteristics of natural skin epidermis-dermis. Background technique [0002] Currently, there are two main treatments for burn wounds: tissue engineered skin to replace original tissue and wound dressing to promote repair of damaged tissue. Natural skin is considered the perfect "wound dressing" and an ideal wound dressing should replicate the characteristics of natural skin as closely as possible. The natural skin has two barrier functions: on the one hand, it prevents the loss of water, electrolytes and other substances in the body; on the other hand, it prevents the invasion of harmful substances from the outside. The skin maintains the stability of the internal environment of the human body, and also partici...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/26A61L15/32A61L15/44A61L15/46A61L15/42D04H1/435D04H1/4382D04H1/728B33Y70/00B33Y80/00
CPCA61L15/26A61L15/28A61L15/32A61L15/44A61L15/46A61L15/42D04H1/435D04H1/4382D04H1/728B33Y70/00B33Y80/00A61L2300/414A61L2300/252A61L2300/404C08L67/04C08L5/08C08L89/00
Inventor 袁志山孙秋梦王成勇曾胜易新
Owner GUANGDONG UNIV OF TECH
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