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A compound projectile system for Demoline skin dressing

A system and skin technology, applied in bandages, medical science, etc., can solve problems such as immature aerosol preparation technology, and achieve strong adsorption tendency, high antibacterial performance, and good safety effects

Active Publication Date: 2022-07-01
JIANGSU YENSSEN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Demoline skin dressings can be processed into gels, powders and aerosols. Among them, aerosols are easy to use, clean, and easy to store. However, the aerosol preparation technology for Demoline skin dressings is not mature enough at present. No. ZL200710020434.8 discloses a projectile system, but this kind of projectile system does not contain disinfection and bactericidal components, and is not suitable for medical aerosols. Therefore, it provides a stable state, good atomization effect, and effective ingredients. The compound projectile system of Gao Demolin skin dressing is a technical problem that needs to be solved at present

Method used

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  • A compound projectile system for Demoline skin dressing
  • A compound projectile system for Demoline skin dressing
  • A compound projectile system for Demoline skin dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A synergist made from the following steps:

[0033] Step 1, add 0.1mol 2-(2-aminoethyl)pyridine, 0.05mol epichlorohydrin and 0.5mL toluene into the three-necked flask, install a condenser tube and a thermometer, turn on the magnetic stirrer, and add hydroxide after stirring for 5min. The potassium ethanol solution was slowly heated to 90 °C, stirred for 4 h, washed with deionized water, separated, and the organic phase was distilled under reduced pressure to remove toluene to obtain intermediate 1, wherein the potassium hydroxide ethanol solution was composed of potassium hydroxide and no Water ethanol is mixed according to 0.5g: 1mL;

[0034] Step 2. Add 0.1 mol of Intermediate 1 and 0.11 mol of Bromododecane into the three-necked flask, and reflux under magnetic stirring for 4 h. After the reaction is completed, transfer the reaction product to ice water, filter after stirring, and filter the cake with acetone / Isopropanol was recrystallized for 5 times, and finally ...

Embodiment 2

[0037] A synergist made from the following steps:

[0038] Step 1, add 0.1mol 2-(2-aminoethyl)pyridine, 0.05mol epichlorohydrin and 0.5mL toluene into the three-necked flask, install a condenser tube and a thermometer, turn on the magnetic stirrer, and add hydroxide after stirring for 5min. The potassium ethanol solution was slowly heated to 90 °C, stirred for 4 h, washed with deionized water, separated, and the organic phase was distilled under reduced pressure to remove toluene to obtain intermediate 1, wherein the potassium hydroxide ethanol solution was composed of potassium hydroxide and no Water ethanol is mixed according to 0.5g: 1mL;

[0039]Step 2. Add 0.1 mol of Intermediate 1 and 0.11 mol of Bromododecane into the three-necked flask, and reflux under magnetic stirring for 5 h. After the reaction is completed, transfer the reaction product to ice water, filter after stirring, and filter the cake with acetone / Isopropanol was recrystallized for 5 times, and finally d...

Embodiment 3

[0042] A synergist made by the following steps:

[0043] Step 1. Add 0.1mol 2-(2-aminoethyl)pyridine, 0.05mol epichlorohydrin and 1.2mL toluene into the three-necked flask, install a condenser and a thermometer, turn on the magnetic stirrer, and add hydroxide after stirring for 5min. The potassium ethanol solution was slowly heated to 110 °C, stirred for 6 h, washed with deionized water, separated, and the organic phase was distilled under reduced pressure to remove toluene to obtain intermediate 1, wherein the potassium hydroxide ethanol solution was composed of potassium hydroxide and no Water ethanol is mixed according to 0.5g: 1mL;

[0044] Step 2. Add 0.1 mol of Intermediate 1 and 0.11 mol of Bromododecane into the three-necked flask, and reflux under magnetic stirring for 6 h. After the reaction is completed, transfer the reaction product to ice water, filter after stirring, and filter the cake with acetone / Isopropanol was recrystallized for 5 times, and finally dried ...

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PUM

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Abstract

The invention relates to a composite propellant system for demoline skin dressings, belonging to the technical field of aerosol preparation, comprising the following raw materials: propellant, latent solvent, dispersant, solubilizer, synergist, sterilization and disinfectant and Emulsifier, no freon propellant, environmentally friendly, healthy and environmentally friendly, and added a self-made synergist, with the characteristics of cationic quaternary ammonium salt type gemini surfactant, containing pyridyl quaternary ammonium salt, with high antibacterial performance, and the synergist contains hydrophilic groups (‑OH, ‑NH 2 , quaternary ammonium salt structure) and lipophilic group (alkyl long chain), showing surface activity and solubilizing effect; adding it to the projectile system can effectively disperse and uniformly adsorb the Demoline skin dressing powder, maintain The state of the system is stable, and it cooperates with the sterilizing and disinfecting agent to play a sterilizing and disinfecting effect, so that the Demoline skin dressing powder can better exert its efficacy.

Description

technical field [0001] The invention belongs to the technical field of aerosol preparation, and in particular relates to a compound projection system for Demoline skin dressing. Background technique [0002] Demoline skin wound dressing is a new type of skin wound dressing developed according to the theory of biomolecular compatibility. It can be used for skin scalds, burns or various abrasions, contusions and cuts on the human body caused by various reasons. etc., Demoline skin wound dressing has many advantages and is widely used in clinical treatment. [0003] Demoline skin dressings can be processed into gels, powders and aerosols, wherein aerosols are easy to use, have good cleanliness, and are easy to store, but the current aerosol preparation technology for Demoline skin dressings is not mature enough, patented No. ZL200710020434.8 discloses a projectile system, but this projectile system does not contain sterilization components and is not suitable for medical aeros...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00C08B37/08
CPCA61L26/0023A61L26/0076A61L26/0066C08B37/003A61L2300/208A61L2300/216A61L2300/404C08L5/08
Inventor 陶国新
Owner JIANGSU YENSSEN BIOTECH CO LTD
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