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Recombinant human collagen gel and preparation method thereof

A human-derived collagen and collagen technology, applied in the field of medical gel, can solve the problem of less treatment methods for vaginal dryness, and achieve the effects of reducing vulvar dryness and tingling symptoms, good film-forming properties, and improving vaginal dryness.

Inactive Publication Date: 2015-12-23
DONGGUAN DAQING MEDICAL DEVICES CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are few treatment methods for vaginal dryness. At present, commonly used drugs for the treatment of vaginal dryness include: topical estrogen ointment, sodium hyaluronate gel, polyvinylpyrrolidone, etc., but each has its own advantages and disadvantages

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0098] A recombinant human collagen, which is composed of the following raw materials in weight percentage:

[0099] Small molecule collagen 1%

[0100] Glycerin 1.5%

[0101] Chitosan quaternary ammonium salt 1%

[0102] Sodium hyaluronate 0.5%

[0103] ε-Polylysine 0.5%

[0104] Borneol 0.3%

[0105] Poloxamer 0.3%

[0106] Coenzyme Q100.3%

[0107] Butanediol 0.3%

[0108] Purified water balance.

[0109] The small molecule collagen is a small peptide collagen with a molecular weight of 100-1000 Daltons.

[0110] The chitosan quaternary ammonium salt is 92% 2-hydroxypropyltrimethylammonium chloride chitosan and quaternization degree 95% dimethyl diallyl ammonium chloride A mixture of chitosan with a weight ratio of 2.5:1.

[0111] A preparation method of recombinant human collagen, comprising the steps of:

[0112] Step A, weighing: Weigh the small molecule collagen, glycerin, chitosan quaternary ammonium salt, sodium hyaluronate, ε-polylysine, borneol, poloxamer...

Embodiment 2

[0116] A recombinant human collagen, which is composed of the following raw materials in weight percentage:

[0117] Small molecule collagen 1.5%

[0118] Glycerin 1.8%

[0119] Chitosan quaternary ammonium salt 1.2%

[0120] Sodium Hyaluronate 0.8%

[0121] ε-Polylysine 0.8%

[0122] Borneol 0.4%

[0123] Poloxamer 0.4%

[0124] Coenzyme Q100.4%

[0125] Butanediol 0.4%

[0126] Purified water balance.

[0127] The small molecule collagen is a small peptide collagen with a molecular weight of 100-1000 Daltons.

[0128] The chitosan quaternary ammonium salt is 93% 2-hydroxypropyltrimethylammonium chloride chitosan and 96% dimethyl diallyl ammonium chloride by quaternization degree A mixture of chitosan with a weight ratio of 2.8:1.

[0129] A preparation method of recombinant human collagen, comprising the steps of:

[0130] Step A, weighing: Weigh the small molecule collagen, glycerin, chitosan quaternary ammonium salt, sodium hyaluronate, ε-polylysine, borneol, po...

Embodiment 3

[0134] A recombinant human collagen, which is composed of the following raw materials in weight percentage:

[0135] Small molecule collagen 2%

[0136] Glycerin 2%

[0137] Chitosan quaternary ammonium salt 1.5%

[0138] Sodium Hyaluronate 1%

[0139] ε-Polylysine 1%

[0140] Borneol 0.5%

[0141] Poloxamer 0.5%

[0142] Coenzyme Q100.5%

[0143] Butanediol 0.5%

[0144] Purified water balance.

[0145] The small molecule collagen is a small peptide collagen with a molecular weight of 100-1000 Daltons.

[0146] The chitosan quaternary ammonium salt is 94% 2-hydroxypropyltrimethylammonium chloride chitosan and quaternization degree 97% dimethyl diallyl ammonium chloride A mixture of chitosan with a weight ratio of 3:1.

[0147] A preparation method of recombinant human collagen, comprising the steps of:

[0148]Step A, weighing: Weigh the small molecule collagen, glycerin, chitosan quaternary ammonium salt, sodium hyaluronate, ε-polylysine, borneol, poloxamer, coenz...

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Abstract

The invention relates to the technical field of medical gels, and in particular relates to a recombinant human collagen gel and a preparation method thereof. The recombinant human collagen gel consists of the following raw materials in percentage by weight: 1-3% of small-molecule collagen, 1.5-2.5% of glycerol, 1-2% of chitosan quaternary ammonium salt, 0.5-1.5% of sodium hyaluronate, 0.5-1.5% of epsilon-polylysine, 0.3-0.7% of borneol, 0.3-0.7% of poloxamer, 0.3-0.7% of coenzyme Q10, 0.3-0.7% of butanediol and the balance of purified water. The recombinant human collagen gel provided by the invention has effects of moisture retention and isolation, can improve vaginal atrophy, increase vaginal elasticity and relieve dyspareunia, and also can improve the wettability and the dry state of a vagina, relieve dry and coarse stabbing pain symptoms of cunnus, and ease itching, calor, skin mucous membrane fissure and diffuse superficial bleeding caused by vaginal dryness.

Description

technical field [0001] The invention relates to the technical field of medical gel, in particular to a recombinant human collagen gel and a preparation method thereof. Background technique [0002] Vagina is an important female reproductive organ, connecting the uterus and external genitalia, not only a channel for menstrual discharge and fetal delivery, but also a sexual organ; its structure is composed of mucous membrane, muscular layer and outer membrane, and is rich in stretchability. The maintenance of normal physiological function of female vagina is closely related to normal vaginal micro-ecological status; while ovarian function, normal vaginal structure, vaginal micro-ecological environment such as vaginal pH value (normally 3.8-4.4), microbial distribution, local cytokines and immune function are all related. It is an important factor affecting the physiological function of the vagina. [0003] When female ovarian function is normal, because estrogen acts on the e...

Claims

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Application Information

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IPC IPC(8): A61K38/39A61K9/06A61K47/10A61K47/16A61K47/34A61K47/08A61K47/36A61P15/02A61K31/722
Inventor 梁奕福
Owner DONGGUAN DAQING MEDICAL DEVICES CO LTD
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