The invention relates to an ordinary treatment medicine for vagina dryness, and in particular relates to recombinant human-derived collagen vagina gel for vaginal dryness. The recombinant human-derived collagen vagina gel comprises the following components in percentage by mass: 0.05-1% of recombinant human-derived collagen, 10-30% of poloxamer 407, 0.5-6% of poloxamer 188, 0.1-2% of sodium hyaluronate, 1-4% of glycerinum, an antibacterial preservative which comprises 0.1-1% of phenoxyethanol, 0.05-3% of sodium methylparaben, 0.01-2% of propylparaben, and the balance of water. By adopting the recombinant human-derived collagen vagina gel, the vagina elasticity can be improved, vaginal atrophy can be alleviated, dyspareunia can be relieved, and the sex satisfaction can be improved; by increasing secreta, improving the vagina wetness and alleviating the dryness of vaginas, pruritus, hotness and chapped skin caused by dryness can be remedied, and the symptoms of dryness and stabbing pain of vulvovagina can be alleviated. In addition, the product cannot affect the pH value of vaginas when used in the vaginas, is free of adverse reaction, and is worthy of clinical popularization and application.