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Method for modifying freshwater fish skin collagen by adjusting alkalinity acidity

A technology for adjusting pH and freshwater fish, applied in the field of collagen modification of freshwater fish skin, can solve the problems of biomaterial change, limited development and application, low gel strength, etc., and achieves low cost, low cost and good safety. Effect

Inactive Publication Date: 2005-06-22
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The problem is that the application of collagen derived from livestock is restricted in areas where people believe in Islam and Muslims live together. At the same time, due to the outbreak and prevalence of infectious diseases such as mad cow disease and foot-and-mouth disease in recent years, people are concerned about collagen derived from livestock. Collagen Safety Casts Big Doubts
However, due to the low gel strength of fish skin collagen, its development and application are limited, making the biological material with high potential value into waste

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Embodiment 1: Freshwater fish (bighead carp, crucian carp, tilapia, etc.) fish skin collagen is prepared into an aqueous solution with a concentration of 1% (weight percent concentration, the same below), and its pH value is 8, and the solution is added Hydrochloric acid with a concentration of 0.5 mol / liter was added while stirring. Adjust the rate of hydrochloric acid addition according to the pH value of the solution. When the pH value is higher than 6.5, the speed of adding hydrochloric acid can be faster, and when the pH value is lower than 6.5, add dropwise instead. Until the pH reaches the isoelectric point 6 of the collagen, the addition of the aqueous hydrochloric acid solution is stopped.

Embodiment 2

[0008] Embodiment two: freshwater fish (bighead carp, crucian carp, tilapia, etc.) fish skin collagen is mixed with concentration and is the aqueous solution of 1%, and its pH value is 4, and adding concentration to this solution is the sodium carbonate of 1 mol / liter Aqueous solution, while adding while stirring. Adjust the rate of adding the aqueous sodium carbonate solution according to the pH of the solution. When the pH value is lower than 5.5, the speed of adding sodium carbonate can be faster, and when the pH value is higher than 5.5, add it dropwise instead. Until the pH reaches the isoelectric point 6 of the collagen, stop adding the aqueous sodium carbonate solution.

[0009] Since collagen is an acid-base ampholyte, its molecular cross-linking state can be changed by changing the pH value, thereby changing its gel strength. By adjusting the pH value to the isoelectric point of collagen, the gel strength of collagen will be maximized.

[0010] The aqueous solution...

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PUM

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Abstract

The invention provides a method for modifying freshwater fish skin collagen by adjusting alkalinity acidity, wherein acids or alkali are employed for adjusting the pH of fresh water fish skin collagen aqueous solution to the isoelectric point of collagen, the acids can be hydrochloric acid, acetic acid or citric acid, the concentration being 0.5-1 mol / L, the alkali can be sodium hydroxide, sodium carbonate or potassium hydroxide, the concentration being 0.5-1 mol / L. The method can increase the gelatin strength of the fresh water fish skin collagen by one times, and high safety can be achieved.

Description

technical field [0001] The invention relates to a method for modifying freshwater fish skin collagen by adjusting pH. Background technique [0002] Collagen is the main protein component of all connective tissues (skin, tendons, ligaments, cartilage, etc.) in animals. Because collagen has many excellent properties, it has a wide range of uses, and its application fields involve medicine, food, daily cosmetics, photography, etc. Especially the application in medicine and food industry is more eye-catching. In the field of medicine, in addition to surgical dressings, hemostatic sponges, surgical sutures, and hemostatic agents, foreign researchers mainly focus on the preparation of collagen injections that can expand human soft tissues using collagen, collagen-based drug delivery systems, skin , bone, cardiovascular, esophagus, trachea, etc., while domestic research and clinical application are still in their infancy. In the food industry, collagen is mainly used as an emuls...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K1/107C07K14/78
Inventor 曾名勇张联英董士远刘尊英
Owner OCEAN UNIV OF CHINA
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