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Nutritional composition for improving muscle function and daily activity

A nutritional composition and functional technology, applied in the field of compositions for improving daily activities of mammals and compositions for improving muscle function of mammals

Inactive Publication Date: 2011-08-03
NV NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But in the latter, the supplementation period was only 2 weeks and / or included only a small number of patients

Method used

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  • Nutritional composition for improving muscle function and daily activity
  • Nutritional composition for improving muscle function and daily activity
  • Nutritional composition for improving muscle function and daily activity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0170] Materials and Method

[0171] Animals. In a temperature-controlled place (12:12 dark-light cycle, where the constant room temperature is 21±1℃), male CD2F1 mice (BALB / cx DBA / 2, Harlan / Charles River the Netherlands). After one week of acclimatization, the mice were divided into weight-matched groups: (1) a control group receiving control food, (2) a tumor-bearing group receiving control food, and (3) a tumor-bearing group receiving experimental food. The data given is derived from a combination of several experimental experiments that have the same animal characteristics and experimental procedures (unless otherwise stated) and differ only in the experimental food used. All experimental procedures were approved by the Animal Ethical Committee (DEC consult, Bilthoven, The Netherlands) and followed the principles of good laboratory animal care.

[0172] Experimental food (type A and B experiments). The experiment is divided into: (A) Designed to test the nutritional componen...

example 2

[0205] Example 2: Formulation example

[0206] The sip feed may specifically contain macronutrients in the range specified in Table 3. Specific examples are given in Table 4. In addition, one or more micronutrients (such as minerals, vitamins, etc.) and / or one or more other food-grade additives (such as flavoring agents, preservatives, non-protein amino acids, such as carnitine) may be present.

[0207] Table 3: Nutritional composition of sip feed (per 100ml)

[0208] Protein substances (equivalent) (g)

9-12

-Contains total whey protein

1-9

-Contains total leucine (g)

1.5-2.5

-Leucine is a free amino acid (g)

0.9-1.5

Carbohydrate (g)

10-25

Fat (g)

2-6

-Unsaturated fat

2-6

-Omega 3 polyunsaturated fat

0.8-2

-Among them EPA, DHA, ETA, DPA

0.2-2

Soluble fat, food g

1-4

[0209] Table 4: Nutritional composition of sipped feed (per 100ml)

[0210] Protein substances (equivalent) (g)

10.1

-Contains total whey protein

2.9

-Contains total leucine (g...

example 3

[0220] Example 3: Muscle protein synthesis in colorectal cancer patients after nutritional supplementation

[0221] The ability of sipped feeds from possible compositions containing specific nutrient combinations as described in Table 4 to affect the rate of muscle protein synthesis was tested and compared with the control products described in Table 8.

[0222] Table 8. Supplement composition

[0223]

[0224] *SNC: 2.9g whey protein, 1.1g free leucine, balanced casein, control casein only

[0225] Research design and methodology

[0226] Research subjects. Subjects are registered based on the inclusion / exclusion criteria described below. All subjects were able to walk, sit and stand independently. Prior to this study, screening procedures were not performed in the context of cancer care. A total of 24 subjects (12 in each group) completed the program. The criteria for inclusion are as follows: (1) imaging evidence of cancer, (2) age> 40 years (male and female), (3) ability to sign...

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Abstract

The invention relates to a nutritional composition comprising (a) at least 18 en% of proteinaceous matter, said proteinaceous matter comprising whey; (b) at least 12 wt% of leucine, based on total proteinaceous matter; and (c) a lipid fraction comprising at least an Omega-3 polyunsaturated fatty acid selected from the group of eicosapentaenoic acid, docosahexaenoic acid, eicosatetraenoic acid and docosapentaenoic acid for improving the muscle function in a mammal, for improving dailyactivity, for improving physical performance, for providing a better prognosis in terms of extended life-expectancy, for improving compliance to an anti-cancer therapy or for improving a quality of life.

Description

Technical field [0001] The present invention relates to a composition comprising a proteinaceous substance containing leucine and an omega-3 polyunsaturated fatty acid. [0002] The present invention also relates to the use of a composition suitable for improving muscle function of mammals. The present invention also relates to the use of the composition suitable for improving the daily activities of mammals. Background technique [0003] Body composition, muscle function and daily activities are clinically highly relevant parameters, because muscle function and daily activities are important contributors to the quality of life of cancer patients. In addition, the improvement of the patient's physical condition as reflected by body composition and physical performance can contribute to its compliance with anti-cancer treatments. For example, the dose of chemotherapy can be provided according to a predetermined schedule without the need to adapt it to the patient's lower body weig...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/305A23L33/00
CPCA23V2002/00A23L1/3051A23L1/3008A23L1/296A23L1/3056A23L33/12A23L33/175A23L33/10A23L33/17A23V2200/30A23V2200/308A23V2250/21A23L33/19A61K31/145A61K31/198A61K31/202A61K31/205A61K31/702A61P21/00A23V2200/316A23V2250/54252A23V2250/54246A23V2250/0628A23V2250/062A23V2250/0616A23V2250/063A23V2250/1862A23V2250/187A23V2250/1868A23V2250/1872A23V2250/0612A23V2250/0644A23L33/40A61K35/20
Inventor 克拉斯克·范诺伦阿德里安乌斯·拉姆贝图斯·贝特霍尔德斯·范赫尔福尔特霍伊塞·法贝尔罗伯特·约翰·约瑟夫·哈格曼阿简·保罗·福斯
Owner NV NUTRICIA
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