A bioactive porous titanium alloy human cervical intervertebral fusion device and its preparation method

Abstract

The invention provides a porous titanium alloy human cervical interbody fusion cage with bioactivity and a preparation method thereof. The method comprises the following steps: firstly, inputting model data into electron beam melting equipment according to a design requirement to prepare a porous titanium alloy human cervical interbody fusion cage; secondly, preparing gelatin microspheres; and immersing gelatin microsphere dry powder in an rhBMP-2 solution for gelatin coating modification, preparing a gelatin solution A in double distilled water, immersing the porous titanium alloy human cervical interbody fusion cage in the gelatin solution A, mixing the rhBMP-2 gelatin microspheres and absolute ethanol to obtain suspension B, and immersing the gelatin-coating-modified porous titanium alloy human cervical interbody fusion cage in the suspension B to prepare the porous titanium alloy human cervical interbody fusion cage internally containing an rhBMP-2 sustained-release system. The cervical interbody fusion cage prepared with the method has modulus of elasticity close to that of natural bone tissues, and the porous structure and the bioactivity factor sustained-release system inside the cervical interbody fusion cage can induce growth of new bone tissues, so that the binding problem of bone-material interfaces is solved. Therefore, the cervical interbody fusion cage has bettermechanical compatibility and bone integration capability than those of a compact material.

Description

technical field [0001] The invention belongs to the field of spinal fusion and internal fixation, and in particular relates to a biologically active porous titanium alloy human cervical intervertebral fusion device and its preparation. Background technique [0002] Cervical degenerative spondylolisthesis, intervertebral segmental instability, and intervertebral disc-derived diseases are common spinal surgery diseases that seriously affect the life and work of patients. Cervical fixation and fusion are generally required for those who fail non-surgical treatment. Intervertebral fusion surgery has been recognized as a good curative effect for such diseases. There are two main types of materials commonly used in intervertebral fusion: ① bone graft materials, including autologous bone block and allogeneic bone block transplantation; ② alternative materials, namely interbody fusion cage (Interbody Fusion Cage). [0003] In the past, autologous bone block transplantation was ofte...

AI Technical Summary

Problems solved by technology

[0005] However, the traditional intervertebral fusion still has certain limitations: ①Titanium alloy intervertebral fusion is mainly made of Ti6Al4V, although its strength is high, its elastic modulus (110GPa) is much higher than that of natural bone (cortical bone is about 3-12GPa). ), there is a metal-bone interface problem, which will cause stress shielding, resulting in bone resorption and implant loosening

②The elastic modulus of PEEK-Cage is close to that of vertebral cortical bone, which avoids stress shielding, but it and titanium alloy are biologically inert materials. Insufficient bonding strength of bone-material interface, prone to loosening

However, its mechanical strength is low, and the inherent brittleness of the material itself makes it easy to break during surgical operations

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