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170 results about "Measles" patented technology
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A respiratory tract viral infection commonly found in children.
Composition for killing virus and preventing influenza and cold prevention plaster prepared by composition
InactiveCN102349991AIncrease concentrationUniform slow releaseAntibacterial agentsBiocideDiseaseRespiratory tract disease
The invention relates to a composition for killing virus and preventing influenza and a cold prevention plaster prepared by the composition. An aromatic traditional Chinese medicine volatile extract product and fragrant plant essential oil are used as effective components of the plaster; high-molecular colloid, which can be compatible with the effective components and has a stereo network structure, and an excipient are used to wrap the effective components to prepare a microcapsule; the microcapsule is used to coat on a matrix to prepare a tablet; a double faced adhesive tape is used to plaster the tablet at the position close to mouth and nose (such as collar, shoulder, chest and the like) so as to allow the effective components to slowly release at uniform speed. The plaster can be used to kill pathogen and virus in the air and enhance the immunity of upper respiratory tract, has an obvious effect of preventing influenza, and has a certain prevention effect for common cold, hand-foot-mouth disease, varicella, measles, epidemic encephalitis B, epidemic mumps, chronic respiratory tract diseases and the like. The plaster is convenient to use, has fragrant smell and is safe without side-effect.
Owner:王红芳
Methods and Compositions for Stabilization of a Virus Vaccine
InactiveUS20110243988A1Improve stabilityReduce pressureBacterial antigen ingredientsViral antigen ingredientsRoom temperatureAttenuated vaccine
This invention provides compositions and methods for stabilizing a live attenuated virus in dried formulations. In particular, compositions and methods of preparing a dried vaccine are provided that stabilize the viability of live vaccines such as measles and adenovirus at room temperature.
Owner:ARIDIS PHARMA INC
Immune response enhancement methods
InactiveUS7101553B2Enhance immune responseMaximum protectionAntibacterial agentsMilk preparationOligosaccharideNutritional composition
A prebiotic for enhancement of an immune response, a nutritional composition for enhancement of an immune response; use of a prebiotic in the manufacture of a medicament or nutritional composition for enhancement of an immune response; use of a prebiotic in the manufacture of a medicament or nutritional composition for the prevention or treatment of measles; a method of enhancing an immune response which comprises administering an effective amount of a prebiotic; and a method of prevention or treatment of measles which comprises administering an effective amount of a prebiotic. In preferred embodiments the prebiotic comprises a fructo-oligosaccharide.
Owner:NESTEC SA
Compositions and methods for generating an immune response
InactiveUS20070048861A1Increase typeSsRNA viruses negative-senseAntibody mimetics/scaffoldsImmunodeficiency virusEukaryotic plasmids
The present invention relates to novel plasmid constructs useful for the delivery of DNA vaccines. The present invention provides novel plasmids having a transcription cassette capable of directing the expression of a vaccine nucleic acid insert encoding immunogens derived from any pathogen, including fungi, bacteria and viruses. The present invention, however, is particularly useful for inducing in a patient an immune response against pathogenic viruses such as HIV, measles or influenza. Immunodeficiency virus vaccine inserts of the present invention express non-infectious HIV virus-like particles (VLP) bearing multiple viral epitopes. VLPs allow presentation of the epitopes to multiple histocompatability types, thereby reducing the possibility of the targeted virus escaping the immune response. Also described are methods for immunizing a patient by delivery of a novel plasmid of the present invention to the patient for expression of the vaccine insert therein. Optionally, the immunization protocol may include a booster vaccination that may be a live vector vaccine such as a recombinant pox virus or modified vaccinia Arbora vector. The booster live vaccine vector includes a transcription cassette expressing the same vaccine insert as the primary immunizing vector.
Owner:ROBINSON HARRIET L +11
Agents for the inhibition of virus replication through regulation of protein folding
The invention concerns agents for the treatment of acute and chronic infections with human and animal pathogenic viruses which assemble along the cell membrane and are released through budding on the surface of the cell. Hereunto count especially causative agents of infectious diseases such as AIDS, hepatitis, hemorrhagic fever, SARS, smallpox, measles, polio or the flu. The subjects of the invention are agents that contain inhibitors of the protein folding as active components. Hereunto count inhibitors of cellular folding enzymes (the enzymatic chaperones) as well as substances that disturb the folding of proteins through chemical chaperones. The following substance classes and their derivates belong thereunto: Geldanamycin, Deoxyspergualin, 4-PBA or Herbimycin A. Due to these agents the highly organised processes of the assembly and the proteolytical maturation of virus structure proteins is disturbed. As a result the release and production of infectious decendent viruses is prevented.
Owner:VIROLOGIK GMBH
DNA expression vectors and methods of use
Owner:EMORY UNIVERSITY
DNA expression vectors and methods of use
The present invention relates to novel plasmid constructs useful for the delivery of DNA vaccines. The present invention provides novel plasmids having a transcription cassette capable of directing the expression of a vaccine nucleic acid insert encoding immunogens derived from any pathogen, including fungi, bacteria and viruses. The present invention, however, is particularly useful for inducing in a patient an immune response against pathogenic viruses such as HIV, measles or influenza. Immunodeficiency virus vaccine inserts of the present invention express non-infectious HIV virus-like particles (VLP) bearing multiple viral epitopes. VLPs allow presentation of the epitopes to multiple histocompatability types, thereby reducing the possibility of the targeted virus escaping the immune response. Also described are methods for immunizing a patient by delivery of a novel plasmid of the present invention to the patient for expression of the vaccine insert therein. Optionally, the immunization protocol may include a booster vaccination that may be a live vector vaccine such as a recombinant pox virus or modified vaccinia Arbora vector. The booster live vaccine vector includes a transcription cassette expressing the same vaccine insert as the primary immunizing vector.
Owner:EMORY UNIVERSITY
Rabdosia rubescens aqueous extract, use of rabdosia rubescens aqueous extract, rabdosia rubescens extract, skin care product and preparation methods of rabdosia rubescens aqueous extract and skin care product
ActiveCN103585074ASignificant human cell repair and regenerationVisibly beautifies and whitens the skinAntibacterial agentsCosmetic preparationsGELSEMIUM EXTRACTAlcohol
The invention relates to the field of skin care products and especially relates to rabdosia rubescens aqueous extract, use of the rabdosia rubescens aqueous extract, rabdosia rubescens extract, a skin care product and preparation methods of the rabdosia rubescens aqueous extract and the skin care product. The preparation method of the rabdosia rubescens extract comprises the following steps of carrying out alcohol extraction on rabdosia rubescens, filtering the alcohol extraction product, distilling the filtrate to obtain rabdosia rubescens alcohol extract, collecting the filter residues, carrying out water extraction on the filter residues, filtering the water extraction product, carrying out distillation to obtain the rabdosia rubescens aqueous extract, and mixing the rabdosia rubescens alcohol extract and the rabdosia rubescens aqueous extract. The skin care product does not contain any chemical additives, is safe and edible, and has functions of whitening skin, freshening skin, preventing prickly heat, relieving itching, removing measles, inhibiting bacteria and repelling mosquitos.
Owner:河南济世药业有限公司
Chimeric poly peptides and the therapeutic use thereof against a Flaviviridae infection
The invention relates to building a chimeric polypeptide used for preventing or treating a Flaviviridae infection. The use of the inventive chimeric polypeptide for producing recombinant viral vectors such as a measles living viral vector is also disclosed.
Owner:INST PASTEUR +1
Preparation method for measles attenuated live vaccine
InactiveCN102406933AInhibit side effectsImprove single batch yieldAntiviralsAntibody medical ingredientsHollow fibreFiber
The present invention relates to the field of vaccine, especially to a preparation method for a measles attenuated live vaccine. The method comprises the following steps: culturing in a microcarrier bioreactor; culturing by a maintenance media; harvesting and purifying; preparing the vaccine and freeze drying. With adopting the high density culture method of the bioreactor, it is ensured that the resulting virus titer is higher than the virus titer from the conventional process; on the premise of the high virus titer by the method of the present invention, a molecular sieve chromatography method or a hollow fiber filtering method is further adopted to carry out purification to remove most of impurity components, such that the generation of the side reactions of the vaccination is effectively avoided. In addition, with adopting the bioreactor to culture the virus, the culture conditions are stable, such that the large-scale production is easy to realize, and the single batch production of the vaccine is increased so as to ensure the quality uniformity and the quality stability of the product.
Owner:CHENGDU KANGHUA BIOLOGICAL PROD
Preparation method of human measles immune sensor based on graphdiyne and silver nanoparticle cage
ActiveCN105842314ASpecific surface area enlargementFacilitates electron transferBiological material analysisMaterial electrochemical variablesSignalling moleculesEngineering
The invention relates to a preparation method of a human measles immune sensor based on graphdiyne and a silver nanoparticle cage, and belongs to the technical field of novel biological sensing and detection. Graphdiyne is of a carbon-carbon triple-bond linear structure with an sp hybridized state and has the advantages of zero cis-trans-isomer, high conjugation and the like; due to excellent electrical, optical and photoelectric properties, graphdiyne is a key material of a novel electronic and photoelectric device of the next generation. Meanwhile, by the use of good pi-pi conjugation effect, a high-flux load of signal molecules is realized, and a signal error caused by instable combination is reduced. Therefore, the human measles immune sensor based on graphdiyne and the silver nanoparticle cage can sensitively detect measles viruses.
Owner:UNIV OF JINAN
Oil-control peeling acne-removal repair facial cleanser and preparation method thereof
ActiveCN106473996AQuality improvementEasy to updateCosmetic preparationsToilet preparationsJojoba oilHamamelis virginiana
The invention provides an oil-control peeling acne-removal repair facial cleanser and a preparation method thereof. Compared with the prior art, in the invention, coconut oil moistens skin and adjusts the secretion of sebaceous gland; aloe oil realizes skin convergence, softening, moisturizing and inflammation diminishing; hazelnut oil softens and moistens the skin; semen armeniacse dalce oil can effectively relieve the skin itching phenomenon while eliminating swelling, dryness and inflammation; jojoba oil regulates grease secretion and improves the skin inflammation and sensitivity, eczema, psoriasis, pimple and the like; mint can treat the skin rubella itching, rash, eczema, measles without adeqrate eruption and the like; sapindus has strong detergency and realizes antibacterial property, inflammation diminishing, oxidation resistance and free radical removal; lavender improves acne, abscess and eczema and can balance grease secretion; and witch hazel realizes convergence oil control and sterilization and balances the skin pH and grease secretion. In the invention, the medicinal components supplement and cooperate with each other to realize an oil-control peeling acne-removal repair effect.
Owner:李双峰
Traditional Chinese medicinal composition for treating infantile adult measles complicated with pneumonia
InactiveCN101167945ALittle side effectsGood curative effectAntiviralsRespiratory disorderSide effectThird generation
The invention relates to a Chinese traditional medicament composition for curing pedo-measles complicated with pneumonia in the Chinese patent medicament field. The technical proposal of the invention is that according to the medicament quantity each day, the proportion by weight is that peucedanum root 3g, almond 3g, mulberry leaves 3g, common anemarrhena 3g, liriope 3g, honeysuckle 9g, trichosanthin 3g, isatis root 9g, rhizoma corydalis 6g and liquorice 1.5g. The invention provides the medicament configuration for pedo-measles complicated with pneumonia. The invention has the efficacies of clearing heat, resolving phlegm, nourishing yin and detoxifying. Through the 56 cases of clinical trials, the cure rate is 39 cases, the effective rate is 47 cases, the side effect is small, and the curative effect is stable.
Owner:刘新萍
Traditional Chinese medicine composition for treating measles and preparation method of traditional Chinese medicine composition
ActiveCN103816422ASignificant effectLittle side effectsAnthropod material medical ingredientsAntiviralsSide effectSaposhnikovia
The invention relates to a traditional Chinese medicine composition for treating measles and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 13-17 parts of carrots, 9-11 parts of coriander, 9-11 parts of rhizoma phragmitis, 6-8 parts of platycodon root, 6-8 parts of almonds, 6-8 parts of honeysuckle, 6-8 parts of folium mori, 6-8 parts of fructus forsythiae, 6-8 parts of folium isatidis, 2-4 parts of radix bupleuri, 2-4 parts of fructus aurantii, 2-4 parts of divaricate saposhnikovia root, 2-4 parts of fructus arctii, 2-4 parts of cicada ecdysis, 2-4 parts of mentha haplocalyx, 2-4 parts of dried orange peel, and 2-4 parts of liquorice. The traditional Chinese medicine composition has the advantages of remarkable curative effect, small side effect and simplicity in preparation method.
Owner:郭相君
System and method for rescuing measles viruses and recombinant measles viruses
PendingCN106957859AImprove rescue efficiencyImprove stabilitySsRNA viruses negative-senseInactivation/attenuationGreen fluorescent proteinPolymerase L
The invention discloses a system and a method for rescuing measles viruses and recombinant measles viruses for expressing GFP (Green Fluorescent Protein) and application. The system provided by the invention comprises the following components: 1) a full-length transcription plasmid pT7MVS191 or pT7MVS191-ATU-GFP containing a measles virus anti-genome; 2) a helper plasmid 1 containing an encoding gene of nucleocapsid protein of the measles viruses; 3) a helper plasmid 2 containing an encoding gene of phosphoprotein of the measles viruses; and 4) a helper plasmid 3 containing an encoding gene of RNA (Ribonucleic Acid) polymerase of the measles viruses. The invention further provides a method for rescuing the measles viruses and the recombinant measles viruses. By adopting the system and the method, the measles viruses and the recombinant measles viruses can be effectively rescued; and the system and the method can be used for developing and applying therapeutic or preventive recombinant measles virus products.
Owner:CHENGDU INST OF BIOLOGICAL PROD
Recombinant measles viruses expressing novel coronavirus proteins and application thereof
PendingCN113480618ASsRNA viruses negative-senseSsRNA viruses positive-senseVirus ProteinMeasles virus IgG
The present invention relates to recombinant measles viruses expressing novel coronavirus proteins, such as S proteins or trimers or functional fragments thereof, vaccines comprising the recombinant measles viruses, and the use of such vaccines for the prevention or treatment of novel coronavirus infections.
Owner:ZHEJIANG UNIV
Device for adding medicines on measles blotches and applying medicines on whole body
The invention relates to the technical field of applying medicines for treating measles, and discloses a device for adding medicines on measles blotches and applying the medicines on the whole body. The device comprises a housing, wherein handles are respectively and fixedly connected to two sides of the housing; a rotating shaft is movably connected to the inner part of each handle; a screw rod is movably connected to one ends away from the handles, of the rotating shafts; a first screw rod is meshed to the surface of the screw rod; connecting rods are movably connected to the surface of thefirst screw rod; a sliding groove is in sliding connection to one end away from the first screw rod, of the connecting rod; a push rod is hinged to a joint of the surface of each sliding groove and acorresponding connecting rod; and a driving component is driven to reverse, the screw rod is driven to move backwards, the first screw rod and a syringe needle are driven to move upwards, the connecting rods are also driven to move upwards, the connecting rods move to stretch a suction bag, and the suction bag is stretched to produce suction force, so that fester flowing out from punctured measlesis sucked to enter the inner part of elastic pipes, and then enters a storage tank to be stored, and the effect that the blotches can be punctured without external mechanisms is achieved.
Owner:JILIN UNIV
Vaccine protection agent, and combined measles and Japanese encephalitis vaccine and preparation method thereof
ActiveCN102512685AImprove stabilityIncreased sensitizationViral antigen ingredientsAntiviralsJapanese encephalitis vaccineEncephalitis
The invention provides a vaccine protection agent which is characterized by comprising the following components by weight: 60 to 200 parts of disaccharides, 3 to 10 parts of gelatin, 0.5 to 10 parts of amino acid, 3 to 10 parts of urea, 3 to 10 parts of sorbitol and 2 to 10 parts of human albumin. The invention also provides a combined measles and Japanese encephalitis vaccine and a preparation method thereof. The vaccine protection agent provided in the invention can effectively enhance stability of the combined measles and Japanese encephalitis vaccine and has a high application value.
Owner:CHENGDU INST OF BIOLOGICAL PROD
Traditional Chinese medicine for treating prior period eruption of adults measles
InactiveCN101152483ACompatibility is simpleLow costAntiviralsUnknown materialsDiseaseAdditive ingredient
A Chinese traditional medicine for curing adult measles in the early eruption period belongs to the Chinese traditional medicine for curing measles. The ingredients of the medicine are 15g of honeysuckle, 15g of dyers woad leaves, 15g of forsythia, 9g of burdock fruit, 10g of almond, 10g of root kudzuvine, 10g of balloon flower roots, 10g of reed rhizome, 6g of mint, 6g of cicada slough and 12g of scutellaria roots; the auxiliary ingredients are 12g of roughhaired holly roots, 12g of puffball and 12g of blackberry lily rhizome under the situation of angina. The medicines used in the prescription are all natural herbs and the Chinese traditional medicine is processed with traditional method; the fetching of material is convenient and the prescription and manufacture method are simple; the expense for manufacturing the medicine is low. The composition of the Chinese herbal medicine is simple and the medicines used in the prescription are all natural ones and the fetching and use are convenient; the manufacture method is simple and the effect is excellent; the price is low; in this way, the herbal medicine is especially fit for people living in remote villages far away from counties and towns; the curing expense for patients with the disease of adult measles in the early eruption period is low which solves the problem that the household income is low and the life is poor and the medical conditions is deficient locally.
Owner:朱兵
Traditional Chinese medicine composition for treating children measles
InactiveCN103623260AGood curative effectQuick resultsAntibacterial agentsAnthropod material medical ingredientsSaposhnikoviaLophatherum
The invention discloses a traditional Chinese medicine composition for treating children measles. The traditional Chinese medicine composition is prepared from the following raw medicines in parts by weight: 14-16 parts of honeysuckle, 14-16 parts of fructus forsythiae, 10-13 parts of schizonepeta tenuifolia, 10-13 parts of saposhnikovia divaricata, 10-13 parts of burdock, 10-13 parts of manyflower glorybower root, 14-16 parts of periostracum cicada, 8-11 parts of lithospermum, 8-11 parts of cortex moutan, 8-11 parts of mint, 10-13 parts of platycodon grandiflorum, 14-16 parts of scutellaria baicalensis, 8-11 parts of lophatherum gracile, 10-13 parts of dandelion, 5-7 parts of liquorice, 9-11 parts of reed rhizome and 9-11 parts of willow branch. The raw medicines are boiled into decoction in water for oral administration. The traditional Chinese medicine composition has the characteristics of short treatment course and remarkable curative effect.
Owner:曹庆礼
Method for preparing tea seed tea by using young tea fruits
The invention belongs to the technical field of fruit tea production, and discloses a method for preparing tea seed tea by using young tea fruits. The method comprises the following steps: selecting young fruits of a perennial tea tree, wherein the diameter of the fruits is 0.5-0.8cm; carrying out sun drying or oven drying for 48 to 72 hours; and performing pile fermentation for 3 to 5 days when the water content is about 15%, carrying out second oven drying until the water content is about 7% after the color turns to be reddish brown, conducting spreading airing and standing for 1 to 2 days,conducting sealing and storing in a dry place. Tea trees have certain fruits, and the local lobular seeds are multi-seeded. Local small-leaf trees bear more seeds, and the tea seed tea is a product with a special flavor formed by processing young tea fruits by several processes. Compared with white tea leaves, the product prepared by the invention has a honey fragrance, has a sweet aftertaste in mouth feel, is durable in brewing, and obviously has more tea polyphenols, caffeine and amino acids than the tea produced in the same period. The tea seed tea can be preserved for a long time under thecondition of sealing at room temperature and at a dry place, has higher health care value with the time going by, the, and has the functions of removing fire, dispelling dampness and treating pedo-measles.
Owner:福鼎市鼎科农业开发有限公司
Traditional Chinese medicine contg. three kinds of herb medicines, and its prepn. method
ActiveCN1724012AVersatileSignificant effectDermatological disorderPlant ingredientsPatriniaHerb medicine
Owner:GUANGXI YINGKANG PHARMA
Complementing cell lines
Owner:JANSSEN VACCINES & PREVENTION BV
Preparation of diploid cell attenuated live vaccine from measles long-47 strain and preparation process thereof
InactiveCN102343087ASmall batch-to-batch varianceReduce remaining amountAntiviralsAntibody medical ingredientsVaccine ProductionCell factory
The invention discloses preparation of a diploid cell attenuated live vaccine from a measles long-47 strain and a preparation process thereof. A measles attenuated live vaccine is prepared from a diploid cell strain, a virus culture vessel serves as a cell factory, and a virus solution can be collected continuously for three times and is stored in the form of concentration solution. The diploid cell attenuated live vaccine passes a monkey neurovirulence test and a safety test. The technology belongs to a great reform on measles attenuated live vaccine production, and plays a qualitative role in improving the production quality of the measles attenuated live vaccine. According to the invention, exogenous factor pollution and the possibility of allergic reaction on a few people existing in chick embryo cell (CEC) production are avoided, and the problems of low production efficiency and low quality are solved.
Owner:CHANGCHUN KEYGEN BIOLOGICAL PROD
Nano golden buckwheat rhizome dispersible tablets and preparation method thereof
InactiveCN102048835AExtract completelyHigh product contentAntiviralsPill deliveryPolygonum fagopyrumAdditive ingredient
The invention discloses a traditional Chinese medicine for treating lung abscess, measles pneumonia and peritonsillar abscess and a preparation method thereof. The preparation method comprises the following steps of: taking 1500g of golden buckwheat rhizome, ultrasonically extracting, filtering, decompressing, concentrating, ultrasonically jetting, spraying and drying; and adding a pharmaceutically acceptable excipient to prepare nano golden buckwheat rhizome dispersible tablets. The invention has the advantages of simple process, strong maneuverability, extraction integrity of medicine active ingredients, high product yield, bioavailability and disintegration speed, good absorption effect and stable quality.
Owner:王建军
Chinese traditional medicine compounds for treating eczema, measles, dermatitis and preparing method thereof
InactiveCN101229261AEasy to takeSimple recipeSkeletal disorderCapsule deliveryJoint arthralgiaMagnolia officinalis
The invention discloses a traditional Chinese medicine for eczema, measles and dermatitis treatment and a preparation method thereof; the invention mainly comprises phellodendron, foetida, atractylodes, dittany skin, kudzuvine root, magnolia officinalis and licorice. The traditional Chinese medicine of the invention has the efficacy of clearing heat and wetness, reinforcing spleen and elevating yang, invigorating spleen to replenish qi, and expressing measles. Meanwhile, the invention mainly treats inducing eruptions, boils and sores, eczema and pudendal itch, unsmooth measles dispersing and damp-heat arthralgia pain, swollen sore throat and other syndromes, and has the advantages of simple formula, easy production, convenient taking by the patients, obvious efficacy and wide application value.
Owner:BEIJING ZHONGKE YONGHE PHARMA TECH
Traditional Chinese medicine composition for treating variability measles
InactiveCN103505530AReduce incidenceReliable detoxification effectAnthropod material medical ingredientsAntiviralsExanthemTherapeutic effect
The invention discloses a traditional Chinese medicine composition for treating variability measles. The traditional Chinese medicine composition comprises the following bulk drugs by weight: 4-9 parts of Platycodon grandiflorum, 10-15 parts of dandelion, 4-6 parts of Adenophora, 4-9 parts of ephedra, 5-12 parts of almond, 4-9 parts of licorice and 12-25 parts of gypsum. The traditional Chinese medicine composition is used for treating measles and can obviously reduce incidence rate of complications. The medicine provided by the invention has reliable effects of abating fever, promoting eruption, cooling diaphragm and detoxifying, and the advantages of easy material acquisition, low price convenience for manufacturing and wide scope of application. Through years of research and clinic observation on hundreds of patients, the traditional Chinese medicine composition for treating variability measles has obvious clinic treatment effect. In the treatment of measles, the medicine provided by the invention can realize stationary fever ablation, no obvious surge or drop; and from fever to normal temperature, 0.5-3 days can be saved. In addition, the medicine can turn the rash into smooth and stable state, and realizes reliable effects of promoting eruption, clearing lung, cooling diaphragm and detoxifying.
Owner:HUANGHUAI UNIV
Mutations responsible for attenuation in measles virus or human respiratory syncytial virus subgroup B
InactiveCN1294628ASsRNA viruses negative-senseVirus peptidesHuman respiratory virusAnti-Measles Virus
Isolated, recombinantly-generated, attenuated measles viruses and respiratory syncytial subgroup B viruses having defined attenuating mutations are described. Vaccines are formulated comprising such viruses and a physiologically acceptable carrier. The vaccines are used for immunizing an individual to induce protection against measles virus or respiratory syncytial subgroup B virus.
Owner:WYETH HOLDINGS CORP
Oral liquid for relieving rheumatic pains and stopping itch, and its preparation method
InactiveCN1481875ANo adverse reactionSafe to takeUnknown materialsImmunological disordersBenzoic acidMedicine
The wind evil dispelling and itch stopping oral liquid with red peony root, earthworm, white peony root, licorice, broom cypress fruit, ledebouriella root, sweet wormwood, and cocklebur fruit. The preparation process includes decoction, concentration, filtering, pH regulation, adding Tween-80 or Tween-60 and nipagin an or adding benzoic acid, adding water, packing and sterilizing. The medicine is used in treating allergic rhinitis, urticaria and pruritus and has obvious curative effect.
Owner:四川泰华堂制药有限公司
Enantiomers of the 1′,6′-isomer of neplanocin A
Enantiomers of 1′,6′-isoneplanocin, including derivatives of the enantiomers of 1′,6′-isoneplanocin, are disclosed along with novel synthetic methods. In particular, a substituted cyclopentane epoxide is synthesized into the enantiomers of 1′,6′-isoneplanocin. Enantiomers of carbocyclic nucleoside analogs of 3-deazaneplanocin to provide D- and L-like 1′,6′-iso-3-deazaneplanocin are also disclosed. The small molecule chemotherapeutic compounds beneficially provide DNA and RNA antiviral activity, demonstrating activity towards, for example, human cytomegalovirus, measles, Ebola, norovirus, dengue, vaccinia and HBV. Compounds exhibiting reduced S-adenosylhomocysteine hydrolase inhibitory effects are disclosed and provide improved toxicity profiles in comparison to neplanocin. The invention provides improved prophylactic and / or therapeutic antiviral efficacy.
Owner:AUBURN UNIV
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