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Nano golden buckwheat rhizome dispersible tablets and preparation method thereof

A kind of buckwheat and nanotechnology, which is applied in the field of nano-gold buckwheat dispersible tablets and its preparation, can solve the problems of low bioavailability, slow disintegration speed, and large dosage

Inactive Publication Date: 2011-05-11
王建军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Golden buckwheat flakes can clear away heat and detoxify, expel pus and remove blood stasis, eliminate phlegm, relieve cough and relieve asthma. It is used to treat symptoms such as acute lung abscess, acute and chronic tracheitis, wheezing chronic tracheitis, bronchial asthma and bacillary dysentery, but there are active ingredients extracted Incomplete, low product content, low bioavailability, large dosage, slow disintegration speed, etc.

Method used

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  • Nano golden buckwheat rhizome dispersible tablets and preparation method thereof
  • Nano golden buckwheat rhizome dispersible tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Take 1500g of golden buckwheat, ultrasonically extract at 40°C for 1 hour, filter the extract, concentrate under reduced pressure at 30°C for 5 hours, put the concentrated solution under reduced pressure in a spray drying tower, and use supersonic jet technology to store it at 30°C under a pressure of 0.01MPa , with supersonic speed instantaneous jet drying, wherein the supersonic jet speed is 360 m / s, using high-energy nano-impact mill to crush the extract extract to below 300 nanometers (completely through 6-18 million mesh), and extracting nano-golden buckwheat 60g of crospovidone, 4g of cross-linked polyvinylpyrrolidone, 8g of croscarmellose sodium, 8g of hydroxypropyl cellulose, 5g of sodium starch glycolate, 14g of micropowdered silica gel, 18g of microcrystalline cellulose, 27g of calcium sulfate, and 18g of sodium chloride , 1 g of citric acid, 1 g of aspartame, 6 g of hydroxypropyl cellulose, and 1 g of magnesium stearate are added to make nano-gold buckwheat di...

specific Embodiment 2

[0013] Take 1500g of golden buckwheat, ultrasonically extract at 60°C for 5 hours, filter the extract, concentrate under reduced pressure at 50°C for 60 hours, put the concentrated solution under reduced pressure in a spray drying tower, and use supersonic jet technology, at 60°C and 0.04MPa pressure , with supersonic speed instantaneous jet drying, wherein the supersonic jet speed is 990 m / s, using high-energy nano-impact mill to crush the extract extract to below 300 nanometers (completely passing through 6-18 million meshes), and extracting nano-golden buckwheat 170g of crospovidone, 12g of cross-linked polyvinylpyrrolidone, 21g of croscarmellose sodium, 21g of hydroxypropyl cellulose, 15g of sodium starch glycolate, 40g of micropowder silica gel, 54g of microcrystalline cellulose, 81g of calcium sulfate, and 54g of sodium chloride , 3 g of citric acid, 3 g of aspartame, plus 20 g of hydroxypropyl cellulose, and 3 g of magnesium stearate to make nano-gold buckwheat dispersib...

Embodiment 3

[0015] Take 1500g of golden buckwheat, ultrasonically extract at 50°C for 3.5 hours, filter the extract, concentrate under reduced pressure at 40°C for 35 hours, place the reduced-pressure concentrated solution in a spray drying tower, and use supersonic jet technology to store it at 45°C and 0.03MPa pressure , with supersonic speed instantaneous jet drying, wherein the supersonic jet speed is 660 m / s, using high-energy nano-impact mill to crush the extract extract into below 300 nanometers (completely passing through 6-18 million meshes), and extracting nano-golden buckwheat 110g of crospovidone, 8g of cross-linked polyvinylpyrrolidone, 15g of croscarmellose sodium, 15g of hydroxypropyl cellulose, 10g of sodium starch glycolate, 27g of micropowder silica gel, 36g of microcrystalline cellulose, 54g of calcium sulfate, and 36g of sodium chloride , 2 g of citric acid, 2 g of aspartame, plus 13 g of hydroxypropyl cellulose, and 2 g of magnesium stearate to make nano-gold buckwheat...

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Abstract

The invention discloses a traditional Chinese medicine for treating lung abscess, measles pneumonia and peritonsillar abscess and a preparation method thereof. The preparation method comprises the following steps of: taking 1500g of golden buckwheat rhizome, ultrasonically extracting, filtering, decompressing, concentrating, ultrasonically jetting, spraying and drying; and adding a pharmaceutically acceptable excipient to prepare nano golden buckwheat rhizome dispersible tablets. The invention has the advantages of simple process, strong maneuverability, extraction integrity of medicine active ingredients, high product yield, bioavailability and disintegration speed, good absorption effect and stable quality.

Description

a technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a nano-gold buckwheat dispersible tablet for treating lung abscess, measles pneumonia and peritonsillar abscess and a preparation method thereof. Two background technology [0002] Golden buckwheat flakes can clear away heat and detoxify, expel pus and remove blood stasis, eliminate phlegm, relieve cough and relieve asthma. It is used to treat symptoms such as acute lung abscess, acute and chronic tracheitis, wheezing chronic tracheitis, bronchial asthma and bacillary dysentery, but there are active ingredients extracted Incomplete, low product content, low bioavailability, large dosage, slow disintegration speed and other deficiencies. Three invention content [0003] In order to overcome the above disadvantages, the object of the present invention is to provide a nano-gold buckwheat dispersible tablet with complete extraction of active ingredients, high product c...

Claims

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Application Information

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IPC IPC(8): A61K36/70A61K9/20A61P11/00A61P11/04A61P31/14
Inventor 王建军
Owner 王建军
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