55 results about "Mild hypothermia" patented technology

A method and system is provided to induce mild hypothermia in a patient through controlled heating of the preoptic anterior hypothalamus (POAH) in conjunction with cooling of patient's body. The system employs an ultrasound transducer that may be positioned extracorporeally to a patient skull for emitting ultrasound energy to the POAH. The ultrasound energy heats the POAH to inhibit thermoregulatory responses of the body such that a cooling means may more effectively cool bodily tissue in order to reduce a patient's core body temperature. Feedback sensors may be positioned at various locations on the patient in order to monitor the patient's core body temperature. A control apparatus included with the system controls the amount of heat the POAH receives and the amount of cooling the body receives based on the feedback signals from the sensors.

Systems, devices, and methods for organ retroperfusion along with regional mild hypothermia. In at least one embodiment of a method of organ perfusion of the present disclosure, the method comprises the steps of positioning at least part of a first catheter having a cannula within an artery of a patient, the first catheter configured to permit arterial blood to flow therethrough and further configured to permit a portion of the arterial blood to flow through the cannula, positioning at least part of a second catheter within a vein of the patient at or near a target organ, the second catheter configured to receive some or all of the portion of the arterial blood, connecting the cannula of the first catheter to a portion of the second catheter so that some or all of the portion of the arterial blood flowing through the cannula is provided into the vein to treat a condition or disease of the target organ, and reducing and / or regulating a temperature of blood flowing through the cannula using a regional hypothermia system operably coupled to the cannula.

The invention discloses an isolated liver perfusion system and method. The system comprises a perfusate temperature control tank, an isolated liver preservation tank, a portal vein perfusion path, a hepatic artery perfusion path, a perfusate backflow path and a bile collector. The portal vein perfusion path is used for conveying perfusate to the portal vein of an isolated liver, the hepatic artery perfusion path is used for conveying perfusate to the hepatic artery of the isolated liver, the perfusate backflow path is used for recycling perfusate flowing out of the isolated liver into the perfusate temperature control tank, and the bile collector is connected with the isolated liver preservation tank and used for collecting bile. The isolated liver is perfused from the portal vein and the hepatic artery through the two paths respectively, the system and method are applicable to damage protection in the isolated liver preservation process, the reperfusion injury of the liver can be significantly relieved, and reliability, stability and repeatability are high. The system and method can effectively store the isolated liver at low temperature, mild hypothermia and normal temperature, and the limitation that the isolated liver needs to be stored at low temperature and the requirement for marginal donor liver preservation cannot be met in the prior art is changed.

A cooling assembly is provided for cooling selected parts of the body of a patient to treat hyperthermia or to induce mild hypothermia in the treatment of strokes. The assembly includes a self-contained cooling unit containing a water supply, a battery operated refrigeration unit and circulating pump. A cooling member is connected to the cooling unit and is adapted for receiving cooled water and contacting selected parts of the patient to cool the patient. The cooling member can be a vest, wrap, blanket, chair, hood or cap.

Systems and methods for selective auto-retroperfusion along with regional mild hypothermia. In at least one embodiment of a system for providing a retroperfusion therapy to a venous vessel of the present disclosure, the system comprises a catheter for controlling blood perfusion pressure, the catheter comprising a body having a proximal open end, a distal end, a lumen extending between the proximal open end and the distal end, and a plurality of orifices disposed thereon, each of the orifices in fluid communication with the lumen, and at least one expandable balloon, each of the at least one expandable balloons coupled with the body, having an interior that is in fluid communication with the lumen, and adapted to move between an expanded configuration and a deflated configuration, and a flow unit for regulating the flow and pressure of a bodily fluid, and a regional hypothermia system operably coupled to the catheter, the regional hypothermia system operable to reduce and / or regulate a temperature of the bodily fluid flowing therethrough.

Systems, devices, and methods for organ Retroperfusion along with regional mild hypothermia. One such system includes a hypothermia system including a hypothermia system outlet and a hypothermia system inlet; and a connector comprising a coolant inlet, a coolant outlet, a coolant reservoir, and a blood lumen, whereby the coolant inlet is configured to couple to the hypothermia system outlet and whereby the coolant outlet is configured to couple to the hypothermia system inlet; whereby a cooling product, when the hypothermia system is connected to the connector, can flow from the hypothermia system, through the hypothermia system outlet, into the coolant inlet, through the coolant reservoir, into the coolant outlet, and into the hypothermia system inlet, so that the cooling product can cool blood flowing through the blood lumen.

The invention discloses a fresh-keeping method of broccoli in the mild hypothermia refrigerator by supplemental lighting and chlorinedioxide. The fresh-keeping method includes the following phases in sequence: transporting the picked broccoli to the mild hypothermia refrigerator; grading, packaging and stacking; lighting and sterilizing; and stocking out. The fresh-keeping method has the advantages that the controllable refrigerating temperature at 3-8 DEG C facilitates manual operation and saves refrigeration energy consumption; the supplemental lighting at a proper dosage and within a proper spectrum enables the stocked broccoli to carry out a weak photometabolism, which facilitates the synthesis and the preservation of the chlorophyll, i.e., the preservation of the greenness, and at the same time remarkably reduces the loss of the vitamin C; The disinfection treatment with the chlorinedioxide at a concentration of 0.03-0.2 MuL / L at intervals is a safe method with an remarkable effect of preventing the broccoli from mustiness, thereby remedying the defect of the mustiness of the broccoli due to a higher temperature set in the refrigerator, deferring decomposing of the broccoli chlorophyll, preserving the greenness and controlling the infection mustiness caused by the pathogenic microorganism.

The invention discloses a mild hypothermia therapy-endovascular heat exchange temperature adjustment control device. The device comprises three parts of an endovascular catheter system, an in vitro salt water circulating system and a heat exchange controller, wherein the endovascular catheter system is connected with the in vitro salt water circulating system through a pipeline to form a closed-loop salt water flow channel; a circulating water pump controls sterile salt water to flow in the closed-loop salt water flow channel, while a heat exchange coil is soaked in refrigerant, and the temperature of the refrigerant can be changed by heating refrigeration equipment, so that the temperature of the sterile salt water is adjusted; and the heat exchange controller consists of the heating refrigeration equipment, a temperature control system and a display operation unit which are connected through a circuit. The heat exchange controller can change the temperature of the salt water in the in vitro salt water circulating system, thus temperature controlled salt water is obtained in the endovascular catheter system; and therefore, the heat is exchanged with blood of a patient through the balloon surface of the catheter system, thus the purpose of core body temperature regulation for central nervous system high-risk patients or low body temperature patients is achieved.

The invention relates to an intravascular mild hypothermia therapy device which comprises a normal saline storage box, a first pipeline, an electronic refrigerator, a second pipeline, a central venous catheter and a third pipeline. The normal saline storage box and the electronic refrigerator are communicated through the first pipeline. The electronic refrigerator and the central venous catheter are communicated through the second pipeline. The central venous catheter and the normal saline storage box are communicated through the third pipeline. A pushing pump is arranged on the second pipeline. The liquid inlet end of a honeycomb meshed heat exchange pipe inside the electronic refrigerator is communicated with the first pipeline, and the liquid outlet end of the honeycomb meshed heat exchange pipe is communicated with the second pipeline. Normal saline inside the normal saline storage box is conveyed by the pushing pump into the honeycomb meshed heat exchange pipe and then cooled by an electronic refrigeration sheet into low-temperature normal saline, one end of the central venous catheter enters a lower plenum central vein from a human body femoral vein puncture opening, a temperature difference between the circularly-flowing normal saline and blood inside the central venous blood vessel, and heat exchange between the surface of the central venous blood vessel and the blood in the patient blood vessel is performed.

Systems and methods for selective auto-retroperfusion along with regional mild hypothermia. In at least one embodiment of a system for providing a retroperfusion therapy to a venous vessel of the present disclosure, the system comprises a catheter for controlling blood perfusion pressure, the catheter comprising a body having a proximal open end, a distal end, a lumen extending between the proximal open end and the distal end, and a plurality of orifices disposed thereon, each of the orifices in fluid communication with the lumen, and at least one expandable balloon, each of the at least one expandable balloons coupled with the body, having an interior that is in fluid communication with the lumen, and adapted to move between an expanded configuration and a deflated configuration, and a flow unit for regulating the flow and pressure of a bodily fluid, and a regional hypothermia system operably coupled to the catheter, the regional hypothermia system operable to reduce and / or regulate a temperature of the bodily fluid flowing therethrough.

Systems and methods for selective auto-retroperfusion along with regional mild hypothermia. In at least one embodiment of a system for providing a retroperfusion therapy to a venous vessel of the present disclosure, the system comprises a catheter for controlling blood perfusion pressure, the catheter comprising a body having a proximal open end, a distal end, a lumen extending between the proximal open end and the distal end, and a plurality of orifices disposed thereon, each of the orifices in fluid communication with the lumen, and at least one expandable balloon, each of the at least one expandable balloons coupled with the body, having an interior that is in fluid communication with the lumen, and adapted to move between an expanded configuration and a deflated configuration, and a flow unit for regulating the flow and pressure of a bodily fluid, and a regional hypothermia system operably coupled to the catheter, the regional hypothermia system operable to reduce and / or regulate a temperature of the bodily fluid flowing therethrough.

The invention discloses a new type of sub-low temperature treatment instrument, which comprises a treatment instrument body, which is provided with a semiconductor chip, a spiral pipeline, a circulating fluid tank, a cold water tank, a human body temperature detector, a first water pump, a second water pump, an electronic Control system and heat dissipation device, an operation panel and an ice blanket are arranged outside the body of the therapeutic apparatus; the electronic control system in the body of the therapeutic apparatus is respectively connected to the human body temperature detector, the semiconductor chip, the first water pump and the second water pump, the semiconductor chip and the screw The pipelines are arranged adjacent to each other, the circulating fluid tank is connected to the first water pump and the spiral pipeline through the pipeline in turn, the spiral pipeline is connected to the ice blanket through the liquid outlet pipeline, the ice blanket is connected to the circulating fluid tank through the liquid return pipeline, and the heat sink is attached to the semiconductor chip It is provided that the heat dissipation device is connected with the cold water tank through the pipeline, and the cold water tank is connected with the second water pump and the heat dissipation device through the pipeline in turn. A novel mild hypothermia therapeutic apparatus provided by the present invention uses a semiconductor instead of a compressor to achieve the effect of temperature control that can be raised or lowered.

The invention relates to a portable box for crania-cerebral perfusion cooling. The portable box comprises a control system (1), a constant temperature cooling device (2), a drive perfusion device (3), a power source (4), an operation panel (5) and external ports (6 and 7). The control system (1) controls flowing of perfusion liquid in the constant temperature cooling device (2) via the external ports (6 and 7) by controlling the drive perfusion device (3). A temperature monitoring component and a water level monitoring component are arranged in the constant temperature cooling device (2), the temperature monitoring component is used for monitoring a temperature signal of the perfusion liquid in the constant temperature cooling device (2) and monitoring an indoor temperature signal, and the water level monitoring component is used for monitoring the liquid level information of the perfusion liquid. The operation panel (5) can display the information of the temperate, the flow rate, the residue liquid amount and the like of the perfusion liquid in real time, a certain amount of crania-cerebral perfusion cooling liquid with the temperature being within the range of 0-4 DEG C is perfused to a brain local area at an appropriate speed, so that the temperature in the area reaches mild hypothermia as soon as possible, and thus the mild hypothermia therapy requirement for ischemic brain injury can be met.

The invention belongs to the technical field of agricultural greenhouse environmental control, and particularly relates to a mild hypothermia phase change heat storing and heat releasing system for agreenhouse. A mild hypothermia phase change material matching with greenhouse environmental characteristics and crop demands with different phase change temperatures is adopted by the system, the material is combined and used to achieve the purposes of sufficient collecting and storing of daylight surplus heat in the greenhouse and the gradient supplying of heat needed at night, a phase change heat storing technology, a mild hypothermia phase change material combination technology and a solar energy utilization technology are organically combined to solve the problems of insufficient heat releasing staying power at the latter half of the night, excessively long delay of heat releasing and the like of the system, and bad weather conditions can be better coped with to ensure an appropriate crop growing environment in the greenhouse.

The invention discloses a gasification circulation thermal power system of a mild-hypothermia thermal source. The system comprises a high-temperature thermal source (1), a power machine (2) and a condensate cooler (3). A working medium outlet of the high-temperature thermal source (1) is connected with a working medium inlet of the power machine (2); the working medium outlet of the power machine (2) is connected with the working medium inlet of the condensate cooler (3); the working medium outlet of the condensate cooler (3) is connected with the heated working medium inlet of the mild-hypothermia thermal source (4) directly or by a liquid phase working medium pressurizing pump (5); and the heated working medium outlet of the mild-hypothermia thermal source (4) is connected with the working medium inlet of the high-temperature thermal source (1) by a gas phase working medium returning and pressurizing pump (6). The system can make the most of heat energy of a low-quality thermal source, thus improving thermal efficiency of the whole thermal circulation system.

Therapeutic application of mild to moderate hypothermia in a medical procedure has been found to provide benefits to patients. For example, application of mild hypothermia in the auditory pathway can prevent functional hearing loss post cochlear implant surgery. Devices have been conceived and reduced to practice that apply localized cooling to a small area such as the basal or middle turn of the cochlea. The devices include a cooling tip with at least one thermo-conductive surface. A heat-transporting fluid is circulated through the cooling tip. After absorbing heat, the heat-transporting fluid may be controllably cooled with a thermoelectric cooling device.

The invention discloses human body temperature adjusting method and device and mild hypothermia treatment equipment. The method comprises the steps: detecting the body temperature value of a patient using the mild hypothermia treatment equipment, and when the error between the detected body temperature value and a target body temperature value in a main controller is larger than a first preset threshold value, sending a first adjusting signal to the main controller for adjusting the target water temperature value output to an auxiliary controller by the main controller; and detecting a water temperature value of a water outlet of the water circulation system, and when an error between the detected water temperature value and a target water temperature value in the auxiliary controller is greater than a second preset threshold value, sending a second adjusting signal to the auxiliary controller for adjusting a control signal output to the semiconductor temperature control assembly by the auxiliary controller. The body temperature of a patient can be accurately increased or decreased; meanwhile, the semiconductor temperature control assembly is adopted for adjusting the temperature,the size of the mild hypothermia treatment equipment can be effectively reduced, and noise and power consumption in the using process are reduced.

Systems, devices, and methods for organ Retroperfusion along with regional mild hypothermia. One such system includes a hypothermia system including a hypothermia system outlet and a hypothermia system inlet; and a connector comprising a coolant inlet, a coolant outlet, a coolant reservoir, and a blood lumen, whereby the coolant inlet is configured to couple to the hypothermia system outlet and whereby the coolant outlet is configured to couple to the hypothermia system inlet; whereby a cooling product, when the hypothermia system is connected to the connector, can flow from the hypothermia system, through the hypothermia system outlet, into the coolant inlet, through the coolant reservoir, into the coolant outlet, and into the hypothermia system inlet, so that the cooling product can cool blood flowing through the blood lumen.

Therapeutic application of mild to moderate hypothermia in a medical procedure has been found to provide benefits to patients. For example, application of mild hypothermia in the auditory pathway can prevent functional hearing loss post cochlear implant surgery. Devices have been conceived and reduced to practice that apply localized cooling to a small area such as the basal or middle turn of the cochlea. The devices include a cooling tip with at least one thermo-conductive surface. A heat-transporting fluid is circulated through the cooling tip. After absorbing heat, the heat-transporting fluid may be controllably cooled with a thermoelectric cooling device

The invention relates to the technical field of pressure sore-prevention mattresses, and particularly relates to a multifunctional child pressure sore-prevention mattress. The pressure sore-preventionmattresses comprises a head-chest part and a leg part, the head-chest part is connected with the leg part through a second water pillow, wherein the head-chest part comprises a first water pillow anda restraining plate body integrally connected with the first water pillow, each leg part comprises a plate block and a shank part, the plate block is connected with the shank part through a third water pillow, the shank part comprises a U-shaped restraining plate body, a second fixing plate is arranged in one first square groove, a second electric telescopic rod is arranged on the lower surface of the second fixing plate, a third fixing plate is arranged in the other first square groove, a third electric telescopic rod is arranged on the lower surface of the third fixing plate, a first fixingplate is arranged in the second square groove, and a first electric telescopic rod is arranged on the lower surface of the first fixing plate; according to the multifunctional child pressure sore-prevention mattress, the head-chest part and leg part are additionally arranged, so that the multifunctional child pressure sore-prevention mattress is suitable for people of different ages, the heightsof the head and legs are locally adjusted for use, and multifunctional head mild hypothermia treatment is provided for patients.

The invention discloses a mild hypothermia therapy-endovascular heat exchange temperature adjustment control device. The device comprises three parts of an endovascular catheter system, an in vitro salt water circulating system and a heat exchange controller, wherein the endovascular catheter system is connected with the in vitro salt water circulating system through a pipeline to form a closed-loop salt water flow channel; a circulating water pump controls sterile salt water to flow in the closed-loop salt water flow channel, while a heat exchange coil is soaked in refrigerant, and the temperature of the refrigerant can be changed by heating refrigeration equipment, so that the temperature of the sterile salt water is adjusted; and the heat exchange controller consists of the heating refrigeration equipment, a temperature control system and a display operation unit which are connected through a circuit. The heat exchange controller can change the temperature of the salt water in the in vitro salt water circulating system, thus temperature controlled salt water is obtained in the endovascular catheter system; and therefore, the heat is exchanged with blood of a patient through the balloon surface of the catheter system, thus the purpose of core body temperature regulation for central nervous system high-risk patients or low body temperature patients is achieved.

The invention discloses a craniocerebral perfusion cooling portable box which comprises a box body, a door and rollers. A partition plate is bilaterally arranged at the bottom end of an inner cavity of the box body, a water tank is arranged on the left side of the top end of the partition plate, a temperature sensor is arranged at the center of the bottom end of an inner cavity of the water tank,a liquid level meter is arranged on the left side of the inner cavity of the water tank, a circulating pump is arranged on the right side of the top end of the water tank, an absorption pipe is mounted at the input end of the circulating pump and positioned in the inner cavity of the water tank, a rectangular box is arranged on the right side of the top end of the partition plate, and a refrigeration sheet is arranged on the inner wall of the rectangular box. According to the box, a perfusion device is integrated into the box body, so that a doctor can conveniently carry the perfusion device when going out, mild hypothermia therapy of a patient is facilitated, saline solution can be kept within set temperature, amount of the saline solution in the water tank can be monitored by the liquidlevel meter, perfusion refrigeration can be implemented by an infusion pump, perfusion quality and effect can be further improved, and use safety is improved.

The invention belongs to the technical field of radiation protection, and relates to a mild-hypothermia protection rat radiation-induced pulmonary injury gene screening and path analyzing method. Themethod includes the following steps of firstly, conducting mild-hypothermia intervention treatment on an established rat radiation-induced pulmonary injury model; secondly, screening out a differential expression gene of the mild-hypothermia treatment radiation-induced pulmonary injury after treatment, and conducting enrichment analysis on the functions of the gene; thirdly, selecting a differential expression remarkable gene after analysis for result verification. By means of the mild-hypothermia protection rat radiation-induced pulmonary injury gene screening and path analyzing method, the mild-hypothermia protection rat radiation-induced pulmonary injury related gene can be screened out, the function and path enrichment analysis is conducted on the differential expression gene, and theexplanation on the gene level is provided for the mild-hypothermia protection rat radiation-induced pulmonary injury.

The invention relates to a preparation method for a rat mild hypothermia animal model. The preparation method comprises the steps as follows: placing a rat into a ventilated rat cage, placing the rat cage into a low temperature environment of 4 DEG C, placing an ice bag outside the rat cage for auxiliary cooling, and continuously monitoring the change of the anal temperature of the rat based on the target temperature of 33 plus or minus 0.5 DEG C; and when the anal temperature is lower than the lowest limit of 32.5 DEG C, moving away the ice bag or placing the rat and the rat cage into a room temperature environment, and when the anal temperature is higher than the highest limit of 33.5 DEG C, moving the rat cage to the low temperature environment of 4 DEG C, and carrying out auxiliary cooling through the ice bag. The invention further provides the rat mild hypothermia animal model and an application thereof. The invention has the advantages as follows: the target temperature is quickly reached; the body temperature fluctuation range is small; the rat skin freezing injury is reduced; and the blood sugar is controlled to be in a normal range.

The invention relates to the technical field of mild hypothermia therapeutic instruments, in particular to an intravascular mild hypothermia therapeutic instrument for the intensive care medicine department. The therapeutic instrument comprises a mild hypothermia therapeutic instrument body; a mounting frame fixedly sleeves the mild hypothermia therapeutic instrument body; electric cylinders are mounted on two symmetrical side surfaces of the mounting frame through screws; the movable ends of the two electric cylinders are vertically downward; the movable ends of the two electric cylinders are each provided with a first long-strip-shaped plate through screws; the two first long-strip-shaped plates and the mounting frame are connected through a plurality of limiting mechanisms; and second long-strip-shaped plates are installed between the two ends of the two first long-strip-shaped plates through screws. The intravascular mild hypothermia therapeutic instrument for the intensive care medicine department is provided with the electric cylinders, the first long-strip-shaped plates and the second long-strip-shaped plates for supporting the therapeutic instrument, and the length of the electric cylinders is adjustable, so that the height of the mild hypothermia therapeutic instrument can be adjusted, and the mild hypothermia therapeutic instrument can treat a patient conveniently.

The invention discloses a method for measuring the sub-low temperature or sub-high temperature tolerance of plants, which comprises the following steps: (1) selecting tender plant tissues, after crushing, adding enzymatic hydrolysis solution and mixing them evenly, and enzymolyzing their cell walls; (2) After the product is washed and purified, a protoplast suspension is obtained, and hydrolytic enzymes are added to the protoplast suspension to maintain low-level regeneration of cell wall cellulose; Warm bath, after the warm bath is over, add ultrapure water to reduce the osmotic potential of the solution, and regularly measure the diameter of the protoplast; (4) use the obtained diameter value of the protoplast to calculate the unit time, unit osmotic potential, and cell membrane per unit area of ​​multiple protoplasts The average value of the net velocity Lp of water entering the cell from the outside of the cell, the greater the difference between the average value of Lp and the Lp value at the appropriate temperature of the selected plant, the worse its sub-low temperature or sub-high temperature tolerance. This method has the characteristics of wide applicability and high resolution.

The invention belongs to the technical field of radiation protection and relates to a protection method for radiation-induced lung injury. The protection method comprises the following steps: injecting amifostine into an organism before irradiation, and controlling a body temperature of the organism within a mild hypothermia range after irradiation. By means of the protection method for the radiation-induced lung injury, disclosed by the invention, the injury degree of lung tissue of the organism after irradiation can be safely and efficiently reduced; and when the amifostine injection before irradiation is combined with the application of controlling the body temperature within the mild hypothermia range after irradiation to prepare a medicament for preventing and / or treating the radiation-induced lung injury, the radiation-induced lung injury can be safely and efficiently prevented and / or treated.

The invention discloses an intravascular sub-low temperature treatment instrument for critical care medicine, which comprises a support box, a connecting partition is arranged in the middle of the support box, and the connecting partition divides the inside of the support box into a cooling chamber and a heating chamber. The inner bottom of the cooling cavity supporting the box is provided with a brine storage box, and the lower end of one side of the brine storage box is connected with a connector through a conduit. The brine in the storage tank is pumped into the S-type heat exchange tube, the brine inside the S-type heat exchange tube can be heated by the electric heating plate, and the brine in the brine storage tank can be cooled by the condenser and the cooling plate. It makes temperature control more convenient. The intravascular hypothermia therapeutic apparatus for critical care medicine has a simple structure and is easy to operate. It can cool the brine, and it is more convenient to heat the brine, which provides convenience for people.

The invention discloses an intravascular heat exchange temperature regulation and control device for mild hypothermia treatment. The regulation and control device comprises a cooling liquid circulating conveying system, cooling liquid is normal saline, the cooling liquid circulating conveying system communicates with a detection device, a detection mechanism is used for detecting the salt content, the temperature and the water pressure of the normal saline, a built-in catheter is arranged in the body of a patient, the head and the tail of the built-in catheter communicate with the cooling liquid circulating conveying system, a controller is arranged beside the cooling liquid circulating conveying system, and the controller is connected with the cooling liquid circulating conveying system and the detection device. The regulation and control device is simple in structure and convenient to use, the detection device can be used for detecting the temperature, the salt content, the water pressure intensity and the pressure stability of the normal saline, meanwhile, deviation is avoided through mercury expansion distance measurement during temperature detection, the detection result is more accurate, and if the temperature has deviation, the temperature regulation and control mechanism is automatically started for reasonable control.