383 results about "Human heart" patented technology

A replacement valve for implantation centrally within the orifice of a malfunctioning native heart valve. The valve is designed for minimally invasive entry through an intercostal opening in the chest of a patient and an opening in the apex of the human heart. The replacement valve includes either a separate anchor (11, 87, 111) or a combined anchor (67) that folds around the malfunctioning native valve leaflets, sandwiching them in a manner so as to securely anchor the replacement valve in a precise, desired location.

Mitochondrial targets for drug screening assays and for therapeutic intervention in the treatment of diseases associated with altered mitochondrial function are provided. Complete amino acid sequences [SEQ ID NOS:1-3025] of polypeptides that comprise the human heart mitochondrial proteome are provided, using fractionated proteins derived from highly purified mitochondrial preparations, to identify previously unrecognized mitochondrial molecular components.

A mitral valve replacement device is adapted to be deployed at a mitral valve position in a human heart. The device has an atrial flange defining an atrial end of the device, a valve body defining a ventricular end of the device, and an annulus support that connects the atrial flange and the valve body, the annulus support including a ring of tabs extending radially therefrom and adapted to engage the native mitral annulus and/or the native leaflet(s) of the human heart. The atrial flange can be seated in the atrium above the native mitral valve annulus in a human heart, and the ring of tabs can engage the native mitral annulus in a manner where the atrial flange and tabs provide a clipping effect to secure the mitral valve replacement device at the native mitral valve position

Embodiments disclose a method for repairing a heart of a human. A method may include introducing a collapsed reinforcing element through the skin into the vascular system of the human. The method may include delivering the reinforcing element into a left ventricle through the arteries. Once inside the left ventricle, the reinforcing element may be expanded to an expanded shape. In certain embodiments, a reinforcing element may be used to structurally reinforce a portion of an endocardial surface of a heart. The reinforcing element may include a preshaped patch and/or a plurality of preshaped flexible conduits. The method may include deploying the reinforcing element soon after a myocardial infarction to inhibit naturally occurring remodeling of the heart. The reinforcing element may be deployed with or without the use of a shaper. In some embodiments, a reinforcement element may be positioned on/coupled to an external surface of a human heart. In some embodiments, a reinforcing element may include an externally positioned apparatus configured to substantially reshape a portion of an interior chamber of a heart.

A method for determining cardiac status comprises for a given patient, constructing a patient-specific, three-dimensional, computational model of the patient's heart; and executing the constructed computational model, said executing generating a quantitative analysis of cardiac function. A method of performing cardiac surgeries comprises: a) assessing surgical options based on a patient-specific, three-dimensional, computational model of a patient's heart; and b) performing surgery based on one or more of the surgical options. A computer system comprises: a) a data source containing data of a patient's heart; b) a modeler coupled to receive data from the data source, the modeler generating a patient-specific, three-dimensional, computational model of the heart based on the heart data; and c) a processor routine for computationally providing information about a certain cardiac function using the three-dimensional heart model and for applying computational, quantitative analysis of the cardiac function, wherein the quantitative analysis of the cardiac function provides an assessment for surgical options, optimizing surgical techniques, or predicting outcomes.

The lead body of a medical lead comprises a distal end portion carrying at least one electrode for placement in the pericardial sac of a human heart. The distal end portion of the lead body includes a multi-turn section having opposed ends, opposing forces applied to the ends tending to flatten the multi-turn section, the multi-turn section being thereby adapted to be retained within the pericardial sac. The turns of the multi-turn section may become progressively smaller from one end of the section to the other end of the section. The multi-turn section may have, in a relaxed state thereof, a generally conical, helical configuration. The at least one electrode may be carried adjacent to the end of the multi-turn section having the larger turns. Alternatively, the at least one electrode may be carried adjacent to the end of the multi-turn section having the smaller turns.

This invention relates to devices and methods for the therapeutic changing of the geometry of the left ventricle of the human heart. Specifically, the invention relates to the left-ventricular lateral wall introduction of an anchoring device to align the papillary muscles.

An introducer system for implantation of pacemaker leads into the venous system of the human heart through the coronary sinus is comprised of a flexible, elongate, outer elongate element having a first shape or bias along a portion. The first shape on the outer element may be prebiased or may be initially straight and subsequently biased once deployed in the body chamber. A flexible, elongate, telescopic inner elongate element has a second shape or bias on its distal portion and has the first shape or bias on a more proximal portion. The inner elongate element is telescopically disposed in the outer sheath. The outer and inner elongate elements are rotatable with respect to each other, such that when the inner elongate element is distally extended from the outer sheath, there exists an angular orientation between the inner and outer sheaths which is congruent, when there is at least partial alignment between the distal portion of the outer elongate element and the more proximal portion of the inner sheath, both having the first shape or bias. This results in the rotation of the distal second shape or curve of the inner elongate element into a predetermined three dimensional location.

Anchoring or docking devices configured to be positioned at a native valve of a human heart and to provide structural support for docking a prosthetic valve therein. The docking devices can have coiled structures that define an inner space in which the prosthetic valve can be held. The docking devices can have enlarged end regions with circular or non-circular shapes, for example, to facilitate implantation of the docking device or to better hold the docking device in position once deployed. The docking devices can be laser-cut tubes with locking wires to assist in better maintaining a shape of the docking device. The docking devices can include various features to promote friction, such as frictional cover layers. Such docking devices can have ends configured to more securely attach the cover layers to cores of the docking devices.

This invention relates to devices and methods for the therapeutic changing of the geometry of the left ventricle of the human heart. Specifically, the invention relates to the apical introduction of an anchoring device to align the papillary muscles.

One embodiment discloses a computerized method of assessing deposits and/or blockages in blood vessels in a human, specifically in a human heart. The method may include inputting patient data and creating a computerized interactive model of a heart based on the patient data. Patient data may include a plurality of images of a least a portion of a human heart. Images may include three-dimensional images. An image may be divided into regions. A property of a region may be assessed. A property may include intensity of brightness of a region or a portion of a region. A region may include one or more voxels or one or more pixels. A method may include comparing a property of a region of a heart from a first image to a second image. The first image and the second image may include equivalent regions acquired during different time periods.

A mitral annuloplasty ring that has an outward and an upward posterior bow. The ring defines a closed, modified oval shape with a minor-major axis dimension ratio of between about 3.3:4 to 4:4. The ring is made of a material that will substantially resist distortion when subjected to the stress imparted thereon after implantation in the mitral valve annulus of an operating human heart. The outward and upward posterior bow of the annuloplasty ring corrects for pathologies associated with mitral valve prolapse, as seen with Barlow's syndrome for instance, in which the leaflets tend to be elongated or floppy. Desirably, the outward bow includes a more pronounced outward bulge having an angular extent that approximately equals the angular extent of the upward bow. Sections adjacent the outward bulge may be relatively straight.

A mitral valve replacement device is adapted to be deployed at a mitral valve position in a human heart. The device has an atrial flange defining an atrial end of the device, a ventricular portion defining a ventricular end of the device, the ventricular portion having a height ranging between 2 mm to 15 mm, and an annulus support that is positioned between the atrial flange and the ventricular portion. The annulus support includes a ring of anchors extending radially therefrom, with an annular clipping space defined between the atrial flange and the ring of anchors. A plurality of leaflet holders positioned at the atrial end of the atrial flange, and a plurality of valve leaflets secured to the leaflet holders, and positioned inside the atrial flange at a location above the native annulus.

Systems and methods for automated segmentation of anatomical structures, such as the human heart. The systems and methods employ convolutional neural networks (CNNs) to autonomously segment various parts of an anatomical structure represented by image data, such as 3D MRI data. The convolutional neural network utilizes two paths, a contracting path which includes convolution/pooling layers, and an expanding path which includes upsampling/convolution layers. The loss function used to validate the CNN model may specifically account for missing data, which allows for use of a larger training set. The CNN model may utilize multi-dimensional kernels (e.g., 2D, 3D, 4D, 6D), and may include various channels which encode spatial data, time data, flow data, etc. The systems and methods of the present disclosure also utilize CNNs to provide automated detection and display of landmarks in images of anatomical structures.

A method of imaging an object, such as a diseased human heart or bone, in a nontransparent medium, such as the human body, involves placing an array of transmitters and receivers in operational association with the medium. The transmitters generate a harmonic (frequency domain) or pulse (time domain) primary electromagnetic field (EM) which propagates through the medium. The primary field interacts with the object to produce a scattered field, which is recorded by the receivers. The scattered EM field components measured by the receivers are applied as an artificial EM field to generate a backscattering EM field. Cross power spectra of the primary and backscattering fields (in the frequency domain) or cross correlation between these fields (in the time domain) produce a numerical reconstruction of an EM hologram. The desired properties of the medium, such as conductivity or dielectric permittivity, are then derived from this hologram.

Disclosed are water-soluble gel-based compositions for the delivery of recombinant adeno-associated virus (rAAV) vectors that express nucleic acid segments encoding therapeutic constructs including peptides, polypeptides, ribozymes, and catalytic RNA molecules, to selected cells and tissues of vertebrate animals. Also disclosed are gel-based rAAV compositions are useful in the treatment of mammalian, and in particular, human diseases, including for example, cardiac disease or dysfunction, and musculoskeletal disorders and congenital myopathies, including, for example, muscular dystrophy, acid maltase deficiency (Pompe's disease), and the like. In illustrative embodiments, the invention provides rAAV vectors comprised within a biocompatible gel composition for enhanced viral delivery/transfection to mammalian tissues, and in particular to vertebrate muscle tissues such as a human heart or diaphragm tissue.

A fluid pressure sensor for a lead or catheter intended for placement in a living organism, such as a human heart, includes a rigid annular or tubular supporting structure and a piezoelectric element disposed on at least a portion of the outer surface thereof. The piezoelectric element delivers an electrical signal when subjected to a pressure variation, and exhibits circumferential sensitivity. The rigidity of the sensor is defined to satisfy predetermined criteria to ensure that the sensor, when sensing pressure transferred to the sensor through an on-growth of tissue on the sensor, which is at least 90% of the signal which the sensor would emit without the on-growth.

The invention relates to the analysis of ECG data by exploiting computerized three-dimensional spatial presentation of the measured data using the vector concept. A three-dimensional presentation of the human heart may be correlated with waveforms specific for standard ECG or derived ECG signals based on the dipole approximation of the heart electrical activity. The three-dimensional heart model may be rotated, and the ECG signals are interactively linked to the model. In the visualization process, different types of signal presentation may be used, including graphical presentation of the heart vector hodograph, graphical presentation of the signal waveform in an arbitrary chosen point on the heart, and graphical presentation of the map of equipotential lines on the heart in a chosen moment. Additional tools for analyzing ECG data are also provided which may be interactively used with the display tools.

An apical implantation mitral valve balloon closure plate blocking body and an implantation method, for human heart repair are disclosed. A balloon closure plate made from an elastic plastic material which may be filled with a gas or a curable liquid is implanted via a small incision on the left side of the chest, enters the left ventricle via the apex, and is placed and fixed at a backflow hole position of a front and rear leaflet closure point of the mitral valve. The present disclosure treats diseases such as functional mitral valve regurgitation, and the success rate for repairing functional mitral valve backflow is more than 90%.

The invention discloses a method for automatically detecting a coronary artery calcified plaque of a human heart. The method comprises the following steps of S1.adopting a deep learning neural networkto segment an original graph of a coronary artery CTA sequence in order obtain a coronary artery extraction graph of the human heart; S2.processing the coronary artery extraction graph of the human heart to generate a straightening picture of each branch vessel; S3.carrying out blood vessel segmentation on each straightening picture to obtain a straightening blood vessel graph of each branch vessel; S4.adjusting a window width and a window level, calculating a pixel value of the whole picture of each straightening blood vessel graph, if a pixel point whose pixel value is greater than 220 exists, determining that a calcified plaque exists, and screening out the straightening blood vessel graph with the calcified plaque; S5.converting the straightening blood vessel graph with the calcifiedplaque into a grey scale graph, filling the pixel point whose gray value is larger than 220 with the color, and obtaining a calcified plaque extraction result; and S6.calculating a rate of stenosis ofthe blood vessel and obtaining a quantization value. The method is effective for detection of most calcified plaques, automatic detection can be realized, and the efficiency is greatly improved.

Apparatus and associated methodology for monitoring correlatable anatomical electrical and sound signals, such as electrical and audio signals produced by human heart activity, including (a) attaching to a selected, common anatomical site ECG (or other) electrode structure, and a multi-axial sound sensor, and (b) simultaneously collecting from adjacent that site both ECG(or other)-electrical and sound signals, where such sound signals arrive adjacent the site along multiple, angularly intersecting axes.