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Method for extracting common macrocarpium fruit total glycoside and application of common macrocarpium fruit total glycoside to preparation of hypoxia tolerant medicines

An extraction method, the technology of cornus officinalis, applied in the field of plant materials, can solve the problems of heart and brain hypoxia and other problems that have not been seen in the total glycosides of cornus officinalis, and achieve the effect of improving the ability of patient brain hypoxia, high utilization rate of raw materials, and promoting hypoxia resistance and adaptation

Inactive Publication Date: 2012-08-01
NORTHWEST UNIV(CN)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there has been no report on the use of total glucosides of cornus to prevent and treat heart and brain hypoxia

Method used

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  • Method for extracting common macrocarpium fruit total glycoside and application of common macrocarpium fruit total glycoside to preparation of hypoxia tolerant medicines
  • Method for extracting common macrocarpium fruit total glycoside and application of common macrocarpium fruit total glycoside to preparation of hypoxia tolerant medicines
  • Method for extracting common macrocarpium fruit total glycoside and application of common macrocarpium fruit total glycoside to preparation of hypoxia tolerant medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Taking Cornus officinalis fresh fruit extract Cornus officinalis dry medicinal material powder 100g as an example, the raw materials used and its extraction method are as follows:

[0029] 1. Boiling

[0030] Put the fresh fruit of Cornus officinalis into boiling water until submerged, cook in boiling water for 10-15 minutes, take it out and cool for a while, squeeze out the core by hand, dry the pulp at 40°C, crush it, and pass through a 20-mesh sieve to obtain the medicinal material of Cornus officinalis powder.

[0031] 2. Enzymatic extraction

[0032] Take 100g of dogwood medicinal material powder, add 2 to 4 times of water to swell, then add 1g of amygdala, the model of amygdala is M0034-1, and amygdala is a commodity sold in the market, sold by Shanghai Kexing Trading Co., Ltd. Adjust the pH value to 4.5 with glacial acetic acid, perform enzymolysis at a constant temperature of 50°C for 4 hours, add ethanol equal in mass to water to terminate the enzymolysis, add...

Embodiment 2

[0036] Taking Cornus officinalis fresh fruit extract Cornus officinalis dry medicinal material powder 100g as an example, the raw materials used and its extraction method are as follows:

[0037] In step 2 of enzymatic hydrolysis and extraction, take 100g of Cornus officinalis medicinal material powder, add 2 to 4 times of water to swell, then add 0.5g of amygdalinase, adjust the pH value to 4 with glacial acetic acid, enzymolyze at a constant temperature of 45°C for 6 hours, add water Equal mass of ethanol, stop enzymolysis, add water until the mass fraction of ethanol is 25% to 27%, use ultrasonic wave with a frequency of 25kHz and a power of 300W to extract for 30 to 40 minutes, pour out the supernatant; The ratio of liquid to material is 12 to 16 times, and the mass fraction is 25% to 27% of the ethanol aqueous solution to extract once, vacuum filtration, combined two extracts, and concentrated under reduced pressure to the extract with a relative density of 1.20 to obtain ...

Embodiment 3

[0040] Taking Cornus officinalis fresh fruit extract Cornus officinalis dry medicinal material powder 100g as an example, the raw materials used and its extraction method are as follows:

[0041]In step 2 of enzymatic hydrolysis and extraction, take 100g of Cornus officinalis medicinal powder, add 2 to 4 times of water to swell, then add 1.5g of amygdalinase, adjust the pH value to 4.5 with glacial acetic acid, enzymolyze at a constant temperature of 50C for 4 hours, add water, etc. quality ethanol, stop enzymolysis, add water until the mass fraction of ethanol is 25% to 27%, use ultrasonic wave with a frequency of 25kHz and a power of 300W to extract for 30 to 40 minutes, pour out the supernatant; Ratio of 12 to 16 times, the mass fraction of 25% to 27% ethanol aqueous solution is extracted once, vacuum filtration, combined two extracts, concentrated under reduced pressure to an extract with a relative density of 1.20, to obtain the ethanol extract of Cornus officinalis .

...

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Abstract

The invention relates to a method for extracting a common macrocarpium fruit total glycoside and application of the common macrocarpium fruit total glycoside serving as active ingredients to the preparation of hypoxia tolerant medicines. The method comprises the following steps of: boiling, performing enzymolysis for extracting and purifying. The pharmacodynamic test proves that the common macrocarpium fruit total glycoside extracted by the method can improve the cardio-cerebral hypoxia capacity of mice, enhance physical strength, improve antifatigue capacity of organisms, and promote the establishment of hypoxia tolerant acclimatization.

Description

technical field [0001] The invention belongs to the technical field of medical preparations containing raw materials or their reaction products with unknown structures, and specifically relates to materials derived from plants. Background technique [0002] Cornus officinalis is the dried and mature pulp of the small deciduous tree Cornus officinalis in the family Cornaceae and the genus Cornus. Also known as cornus, jujube skin, etc., it tastes sour and astringent, and is slightly warm in nature. It has the functions of warming and nourishing the liver and kidney, and strengthening the essence. One of traditional Chinese medicine. [0003] The main chemical components of Cornus officinalis are polysaccharides, organic acids and esters, iridoid glycosides and aglycones, tannins and volatile components. Among them, iridoid glycosides are the main active parts in Cornus officinalis. The currently identified iridoid glycosides include morroniside, loganin, swertigenin, corno...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/40A61P39/00
Inventor 孙文基梁晋如朱砂余静洁
Owner NORTHWEST UNIV(CN)
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