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37 results about "Small artery" patented technology
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Coronary microvascular disease (sometimes called small artery disease or small vessel disease) is heart disease that affects the walls and inner lining of tiny coronary artery blood vessels that branch off from the larger coronary arteries.
Thrombus removal system and process
InactiveUS20060224177A1Reducing non-rigid contactReduce contactCannulasDilatorsGrip forceSmall artery
A device captures and assists in the removal of a thrombus in arteries, even in small arteries. The device uses a soft coil mesh to engage the surface of a thrombus, and a guidewire is used to retract the soft coil mesh with the captured thrombus. The soft coil is formed by an elongated microcoil element that forms the helical elements of a macrocoil element. The microcoil element provides a relatively elastic effect to the helical element forming the macrocoil and allows for control of gripping forces on the thrombus while reducing non-rigid contact of the device with arterial walls.
Owner:NEXGEN MEDICAL SYST
Thrombus removal system and process
A device captures and assists in the removal of a thrombus in arteries, even in small arteries. The device uses a soft coil mesh to engage the surface of a thrombus, and a guidewire is used to retract the soft coil mesh with the captured thrombus. The soft coil is formed by an elongated microcoil element that forms the helical elements of a macrocoil element. The microcoil element provides a relatively elastic effect to the helical element forming the macrocoil and allows for control of gripping forces on the thrombus while reducing non-rigid contact of the device with arterial walls.
Owner:NEXGEN MEDICAL SYST
Methods for improving the structure and function of arterioles
ActiveUS20060234908A1Simple structureFunction increaseNervous disorderTetrapeptide ingredientsSmall arteryStructure and function
The present invention relates to the unexpected finding that vessels smaller than even the smallest arteries (i.e. arterioles) thicken, become dysfunctional and cause end organ damage to tissues as diverse as the brain and the kidney. This invention provides a method to improve the structure and function of arterioles and preserve the function of end organs such as the brain and kidney.
Owner:RGT UNIV OF CALIFORNIA
Methods for improving the structure and function of arterioles
ActiveUS7579319B2Simple structureFunction increaseNervous disorderTetrapeptide ingredientsAmphipathic helixSmall artery
The present invention relates to the unexpected finding that vessels smaller than even the smallest arteries (i.e. arterioles) thicken, become dysfunctional and cause end organ damage to tissues as diverse as the brain and the kidney. This invention provides a method to improve the structure and function of arterioles and preserve the function of end organs such as the brain and kidney. In certain embodiments, the methods involve administering to a human having thickened arterioles in brain, kidney or alveoli a peptide that ranges in length up to 30 amino acids, and that comprises a class A amphipathic helix, and bears at least one protecting group.
Owner:RGT UNIV OF CALIFORNIA
Apparatus and methods for dilating vasospasm of small intracranial arteries
A device and method for treatment of intracranial vasospasm is provided. The device is a microcatheter having a steeply tapered end and is thicker walled, and in a preferred embodiment is braided to provide greater pushability. In order to achieve a thicker walled catheter, in one embodiment, the inner lumen diameter can be reduced, leaving the outer diameter the same while in another embodiment the catheter is larger in outer diameter. In one embodiment, the microcatheter is coated with performance enhancing lubricant, such as a hydrophilic coating. Further, the microcatheter can also be coated with drugs and serve as a drug delivery device, drugs being embedded into vessel intima. In the use of the method of treatment, the device is fed into the smaller arterial vessels in the brain simultaneously dilating arteries of various caliber along the path of the catheter to relieve vasospasm; pharmacological agents can then be delivered by the microcatheter to further effect treatment.
Owner:THE BOARD OF TRUSTEES OF THE UNIV OF ILLINOIS
Hair growth inducer
InactiveCN106138058AReduces symptoms associated with shedding diseaseImprove regenerative abilityOrganic active ingredientsCosmetic preparationsDiseaseTofacitinib
The invention discloses a hair growth inducer, which comprises an active ingredient composed of tofacitinib and minoxidil with a mass percentage of 0.1:99.9-99.9:0.1. The hair growth inducing agent provided by the invention, its active ingredient comprises tofacitinib and minoxidil, wherein tofacitinib is a kind of JAK inhibitor, can interact with target cells (such as dermis, epidermis, dermal papilla cells or hair follicles) Cell) specific protein active site selectively binds, inhibits the transmission of cell pathway signals and the synthesis of characteristic cytokines, thereby reducing the symptoms associated with hair loss diseases; Minoxidil is a potassium ion channel opener that can directly relax Vascular smooth muscle has a powerful dilation effect on small arteries, reduces peripheral resistance, promotes the growth of hair follicle cells, and thus regenerates hair; the combination of these two substances synergistically acts on the target protein of target cells and vascular smooth muscle, and inhibits cytokines Synthesis and accelerated blood circulation, in order to achieve a significant effect of promoting hair regeneration.
Owner:颜晓丽
Liquid medicine to be taken orally for curing primary hypertension and the preparing method
InactiveCN101032619AGood curative effectQuick resultsSolution deliveryEmulsion deliveryOral medicineSide effect
The present invention discloses oral medicine liquid for treating primary hypertension and its preparation process. The oral medicine liquid has active components prepared with roasted astragalus root, Dangshen, fried white atractylodes rhizome, dried old orange peel, angelica and other 18 kinds of Chinese medicinal materials, and is prepared through twice decoctions, concentrating decoction, bottling and sterilizing. It can eliminate repeated spasm of body's small arteries, eliminate stasis matter and restore renal blood flow to stabilize blood pressure. It has convenient taking, no recurrence, no toxic side effect and other advantages. The present invention also discloses the new application of the medicine liquid in preparing medicine.
Owner:贾聚宝
1,3-bis-(substituted-phenyl)-2-propen-1-ones and their use to treat VCAM-1 mediated disorders
InactiveUS7078431B2Extended half-lifeReduce solubilityBiocideOrganic chemistryPercent Diameter StenosisArthritis
It has been discovered certain 1,3-bis-(substituted-phenyl)-2-propen-1-ones, including compounds of formula (I) inhibit the expression of VCAM-1, and thus can be used to treat a patient with a disorder mediated by VCAM-1. Examples of inflammatory disorders that are mediated by VCAM-1 include, but are not limited to arthritis, asthma, dermatitis, cystic fibrosis, post transplantation late and chronic solid organ rejection, multiple sclerosis, systemic lupus erythematosis, inflammatory bowel diseases, autoimmune diabetes, diabetic retinopathy, rhinitis, ischemia-reperfusion injury, post-angioplasty restenosis, chronic obstructive pulmonary disease (COPD), glomerulonephritis, Graves disease, gastrointestinal allergies, conjunctivitis, atherosclerosis, coronary artery disease, angina and small artery disease.
Owner:SALUTRIA PHARMACEUTICALS LLC
Application of salvianolic acid A in preparation of drugs for preventing and/or treating pulmonary arterial hypertension
InactiveCN106176703AReduce mortalityPromote hypertrophyOrganic active ingredientsRespiratory disorderPulmonary vasculaturePressure rise
The invention relates to novel pharmacological action of traditional Chinese medicine salvianolic acid A and application thereof in the preparation of products for preventing, relieving and / or treating pulmonary arterial hypertension and its complications. The salvianolic acid A has the advantages that the salvianolic acid A has the pharmacological action of relieving pulmonary circulation pressure rise, the pharmacological actions of relieving right heart failure due to pulmonary arterial hypertension, improving right ventricular hypertrophy and right ventricular enlargement, improving heart injury due to pulmonary arterial hypertension, and restoring from heart failure, and the pharmacological actions of lowering endothelin-1 level in pulmonary tissues, relieving pulmonary arterial remodeling and improving pathologic damage of pulmonary tissues; the salvianolic acid A is a monomer compound extracted from Salvia miltiorrhiza, has low toxicity, has a wide source range of material, has promising application and development prospect, is an ideal novel traditional Chinese medicine monomer for treating pulmonary arterial hypertension and its complications, and may be applied to prepare products for preventing, relieving and treating pulmonary arterial hypertension and its complications, such as chronic obstructive pulmonary emphysema, chronic pulmonary heart disease and heart failure.
Owner:INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
Rapid hemostatic
ActiveCN106492265AIncrease temperatureAvoid painSurgical adhesivesPharmaceutical delivery mechanismSmall arterySkin temperature
The invention relates to a rapid hemostatic. Preparation raw materials of the rapid hemostatic comprise microporous starch, calcium ions or zinc ions, chitosan or chitin. In every 100 g of the microporous starch, the addition amount of the chitosan or chitin is 1 to 50 g, the addition amount of the calcium ions is 10 to 500 micromoles, or the addition amount of the zinc ions is 6 to 80 micromoles. When the rapid hemostatic disclosed by the invention is not used, the temperature of skin at a wound cannot be increased obviously, and sharp temperature rise of the wound during hemostasis can be effectively prevented, so that pains of a patient due to the fact that the temperature of the wound is increased when an existing hemostatic is used are avoided, and the novel hemostatic can be used for hemostasis of internal and external wounds under various middle and small arteries.
Owner:NORTHWEST UNIV(CN)
Blood vessel expansion equipment
The invention relates to the technical field of medical equipment, and discloses blood vessel expansion equipment. The blood vessel expansion equipment comprises an expansion stent, a monitor, a dataprocessor and an electromagnetic suspension driving assembly; the expansion stent has the shrinkage form and the expansion form and is used for excising thromboses and expanding the blood vessels; themonitor is used for detecting the position and the form of the expansion stent, and generating data signals according to the detected position and form; the data processor is in signal connection with the monitor and is used for generating control signals according to the data signals; the electromagnetic suspension driving assembly is in signal connection with the data processor and is used fordriving the expansion stent to move according to the control signals and driving the expansion stent to be switched into the expansion form from the shrinkage form according to the control signals. The diameter of the expansion stent in the blood vessel expansion equipment in the shrinkage form can be made smaller, the blood vessel expansion equipment can be applied to thrombosis treatment of medium and small arteries and veins, and the influence of the initial guiding-in position of the expansion stent on a patient is smaller.
Owner:FUZHOU BOE OPTOELECTRONICS TECH CO LTD +1
Compound medicine for treating various diseases related to heart blood supply
ActiveCN1939331AReduce no-reflowImprove blood supply to the heartHydroxy compound active ingredientsCardiovascular disorderDiseaseVein
A kind of compound medicines for treating the diseases associated with blood supply of heart is a composition of adenosine and nitrate chosen from glycerin nitrate, isosorbitol nitrate and 5-isosorbitol mononitrate.
Owner:GRAND LIFE SCI (LIAONING) CO LTD
High-simulation multi-operation skill training examination model for orthopaedics first-aid
The invention relates to a medical teaching aid, in particular to the manufacture of simulated subcutaneous tissue used for simulating skin of high-simulation human body model and TPE and other thermoplastic elastic bodies for simulating muscles, a skeleton is formed by using hard PVC and a 10% X-ray contrast agent mould and is provided with a simulated bone marrow cavity, and a metaphyseal end isprovided with simulated cancellous bone; the skeleton can be developed on an X-ray film without metal artifacts; the limbs on one side are made into various fractures with fracture lines / sections andare provided with a full-automatic blood circulation simulator for simulating the connection of arterioles; a simulated joint dislocation is made on the other side of the limbs without fracture; thefirst aid of limbs fracture can be fixed by a small splint, external fixation such as small splint and the like can be adopted after the fracture is manually restored, and complicated fracture can betreated by internal fixation of operation, so that the injured artery has lifelike small artery jet bleeding during the operation; the model can be used for carrying out various orthopedic operationssuch as bone traction, reduction of joint dislocation and the like, the model is used for carrying out orthopedic emergency treatment and various orthopedic operation skills training on medical students in the department of bone injuries in medical colleges and hospitals, and the teaching effect is obviously improved.
Owner:营口市贵东医疗器械制造有限公司
Application of glycyrrhetinic acid in preparing drug for treating pulmonary arterial hypertension
InactiveCN108721303APrevent oxidationInhibit expressionOrganic active ingredientsRespiratory disorderSmall arteryBeta-Glycyrrhetinic Acid
The invention discloses application of 18 beta-glycyrrhetinic acid in preparing a drug for treating pulmonary arterial hypertension. An experiment result of the invention shows that when the 18 beta-glycyrrhetinic acid is used in a safe dose range, the 18 beta-glycyrrhetinic acid with the dose of 200mg / kg can remarkably improve the mean pulmonary arterial pressure and the right ventricular systolic pressure of a mouse and lowers the right ventricular and pulmonary small artery remodeling; and the experiment result proves that the 18 beta-glycyrrhetinic acid has the therapeutical effect to thepulmonary arterial hypertension.
Owner:NINGXIA MEDICAL UNIV
Hypotensive composition
InactiveCN104840789ARelieve peripheral arteriolar spasmTo achieve the purpose of reducing blood pressureMetabolism disorderBlood disorderSmall arterySide effect
Owner:ZHANGJIAGANG WUHU NEW MATERIAL TECH DEV
Electrode for continuously stimulating facial nerve root and apparatus for monitoring electromyograms of facial muscles using the electrode thereof
ActiveUS8897882B2Reduced responseStable stimulationSpinal electrodesElectromyographySmall arteryAnterior inferior cerebellar artery
An electrode for continuously stimulating a facial nerve root capable of a stable holding required for an electrode that continuously stimulates a facial nerve root, and an apparatus for monitoring electromyograms of facial muscles using the electrode for continuously stimulating the facial nerve root, are provided. The electrode for continuously stimulating the facial nerve root comprises an electrode unit, a contact unit, a guard unit, an extension unit, and a wire unit. The electrode for continuously stimulating the facial nerve root is held by clamping the extension unit between the facial nerve root and the anterior inferior cerebellar artery or the small artery so that the contact unit closely contacts to the facial nerve root and is fixed.
Owner:NAKATOMI HIROFUMI +1
Application of myosin 1b as target for atherosclerosis diagnosis and treatment
PendingCN111979311AReliable resultsOrganic active ingredientsMicrobiological testing/measurementSmall arteryMrna expression
The invention provides application of myosin 1b as a target for atherosclerosis diagnosis and treatment. Whether a subject suffers from atherosclerosis or not is judged by detecting the expression level of the myosin 1b in blood of the subject, and if a mRNA expression level of the myosin 1b in a blood sample is up-regulated (highly expressed), the owner of the blood sample is an atherosclerotic patient. Detection results are accurate and reliable, and the application value of clinical diagnosis is achieved; besides, atherosclerotic plaque can be reduced by targeting a myosin 1b gene or protein, a foundation is laid for developing novel drugs for treating the atherosclerotic based on the target, and potential application value is achieved.
Owner:NORTHWEST UNIV
Heart rate variability detection method based on smart phone camera
PendingCN114052690AAvoid missing detectionAvoid false detectionCatheterSensorsSmall arteryFrequency spectrum
The invention provides a heart rate variability detection method based on a smart phone camera. According to the method, a finger is attached to a camera of the smart phone, a flash lamp of the smart phone is turned on, the camera is used for shooting a video for a period of time, then a video signal is processed, and a pulse wave signal can be extracted from the video signal. The principle of the method is very similar to that of photoelectric volume pulse waves. When the heart is contracted, the small artery of the fingertip is hyperemia, the light absorption is strong, and the image is dark; when the heart is diastolic, blood of the small artery of the fingertip flows back, light absorption is weak, and the image is bright. Therefore, the brightness change of the image reflects the blood volume change when the heart beats, and a time sequence pulse wave signal can be obtained by calculating a brightness value for each frame of image. And time domain peak detection or spectrum analysis can be carried out on the wave signal to calculate a heart rate value. The feature points of the pulse waves are further analyzed, the time interval of each heartbeat is calculated, and then heart rate variability analysis can be conducted.
Owner:霍欣怡 +1
Endometrial stem cell preparation and preparation method for treating erectile dysfunction
ActiveCN112043726BImprove microcirculationPromote generationCell dissociation methodsInorganic non-active ingredientsSmall arteryTissue repair
Owner:伯仕利生物科技发展(盐城)有限公司
Carboxy-dii compound and its preparation method and application
ActiveCN111747880BGood choiceStrong specificityOrganic chemistryFluorescence/phosphorescenceSmall arteryIntraarterial infusion
Owner:武汉市第四医院
Micro needle-shaped electrode for identifying arteries and veins in operation
PendingCN113509177AReduce Surgical InjuriesImprove postoperative resultsSensorsBlood characterising devicesSmall arteryVenous blood
The invention discloses a micro needle-shaped electrode for identifying arteries and veins in an operation. The micro needle-shaped electrode comprises the following steps: measuring blood sample saturation values of main arteries, middle arteries and small arteries of normal adult monkeys; measuring blood sample saturation values of main veins, middle veins and small veins, respectively measuring two main arteries, two middle arteries and two small arteries; simultaneously measuring two main veins, two middle veins, two small veins, surgically anatomizing spermatocordia veins; measuring each vein and artery, measuring the blood oxygen saturation degree of each artery and vein, and statistically analyzing arterial and venous differences, and counting the difference between the artery average value and the vein average value, and judging whether the measured value has comparability and overlapping. According to the micro needle-shaped electrode designed according to the arteriovenous blood oxygen saturation degree principle, arteries and veins can be effectively distinguished in an operation by noninvasively detecting the blood oxygen saturation degree in a blood vessel, the micro needle-shaped electrode is used for distinguishing arteries and veins in a varicocele operation, operation accidental injuries can be effectively reduced, and the postoperative effect can be effectively improved.
Owner:广东省计划生育科学技术研究所
Carboxy-DiI compound as well as preparation method and application thereof
ActiveCN111747880AGood choiceStrong specificityOrganic chemistryFluorescence/phosphorescenceSmall arteryAqueous solubility
The invention relates to a Carboxy-DiI compound as well as a preparation method and application thereof; the Carboxy-DiI compound is used as a fluorescent dye with higher water solubility, is high influorescence efficiency, can be used for arterial perfusion of a living heart and uniform labeling of micro-artery vascular endothelial cells, and is good in specificity and high in sensitivity.
Owner:武汉市第四医院
Gloves with chilblain preventing function
InactiveCN103211329AAvoid generatingAcceleration cycle functionProtective garmentSmall arterySurface layer
The invention discloses gloves with a chilblain preventing function. Each glove comprises an outer layer, a Chinese herbal medicament-filled layer, an inner surface layer and a massage layer; the Chinese herbal medicament-filled layer is arranged between the outer layer and the inner surface layer; the massage layer is embedded into the inner surface layer; the Chinese herbal medicament-filled layer consists of Chinese herbal ointment, a volatilization preventing layer and an inward-permeable layer; the volatilization preventing layer is adhered to the outer surface of the Chinese herbal ointment for preventing chilblain; and the inward-permeable layer is adhered to the inner surface of the Chinese herbal ointment for preventing the chilblain. The gloves with the chilblain preventing function are provided with the Chinese herbal ointment for preventing the chilblain and the massage layers, have the functions of activating local subcutaneous small artery blood flow stasis and accelerating blood circulation, and can effectively prevent the chilblain from generating and effectively keep hands away from the chilblain.
Owner:王红
Medicine for treating hypertension and improving arteriolar elasticity and preparation method thereof
ActiveCN103845363BLower blood pressureImprove clinical symptomsCardiovascular disorderMolluscs material medical ingredientsSmall arteryQuality of life
The invention provides a pharmaceutical composition for treating hypertension and improving arteriole elasticity and a preparation method thereof. The pharmaceutical composition of the present invention is composed of pure natural plant medicine pearls, etc., which can significantly reduce the blood pressure of patients with essential hypertension, has a significant curative effect, and can improve the elasticity of arterioles, thereby protecting target organs, and significantly improving the clinical symptoms of patients. Improve the quality of life, and good security, worthy of clinical application.
Owner:HEBEI YILING MEDICINE INST
a vasodilator device
Owner:FUZHOU BOE OPTOELECTRONICS TECH CO LTD +1
Compound for treating pulmonary arterial hypertension and application thereof
PendingCN113509467AOrganic active ingredientsSenses disorderArterial smooth muscle cellsSmall artery
The new application of the proton pump inhibitor and the derivative thereof in treating pulmonary arterial hypertension is found for the first time. According to the present invention, a monocrotaline is adopted to induce a rat pulmonary arterial hypertension model, a platelet derivative growth factor-BB (Platelet-Derived Growth Factor, PDGF-BB) is adopted to induce abnormal proliferation of pulmonary arterial smooth muscle cells (PASMC), and it is found that the proton pump inhibitors such as dexlansoprazole and the like and the derivatives thereof can reduce the pulmonary arterial pressure, alleviate the thickening of small arteries in the lung, inhibit the abnormal proliferation of the PASMC, so pulmonary arterial hypertension is treated.
Owner:EAST CHINA UNIV OF SCI & TECH
a rapid hemostatic agent
ActiveCN106492265BIncrease temperatureAvoid painSurgical adhesivesPharmaceutical delivery mechanismSmall arteryZinc ion
The invention relates to a rapid hemostatic agent. The preparation raw materials include microporous starch, calcium ions or zinc ions, chitosan or chitin. For every 100g of microporous starch, the amount of chitosan or chitin added is 1-50g, the amount of calcium ions added is 10-500μmol or the amount of zinc ions added is 6-80μmol. The rapid hemostatic agent of the present invention will not cause the skin temperature at the wound to rise significantly when used, and can effectively prevent the temperature at the wound from rising significantly when hemostasis is used, avoiding the risks to patients caused by the increase in the temperature at the wound when the existing hemostatic agent is used. It can be used to stop bleeding from internal and external trauma under various small and medium-sized arteries.
Owner:NORTHWEST UNIV
Use of isorhamnetin in preparation of drugs for treatment of pulmonary hypertension
PendingCN110652507AReduce refactoringReduce hypertrophy indexOrganic active ingredientsRespiratory disorderSmall arteryBlood flow
The invention discloses use of isorhamnetin in preparation of drugs for treatment of pulmonary hypertension. The isorhamnetin is applicated at a dose of 50-150mg / kg, hemodynamic parameters and echocardiographic parameters of pulmonary hypertension model rats can be significantly improved, and reconstruction of a right ventricle and pulmonary small arteries are reduced.
Owner:NINGXIA MEDICAL UNIV
Liquid medicine to be taken orally for curing primary hypertension and the preparing method
InactiveCN101032619BGood curative effectQuick resultsSolution deliveryEmulsion deliveryOral medicineSmall artery
Owner:贾聚宝
Noninvasive continuous blood pressure measurement device
ActiveCN103110431BEliminate negative effectsMeasure directlyBlood pressure measurement devicesSmall arteryMeasurement device
The invention relates to a noninvasive continuous blood pressure measurement device and a method. By the combination of the technology of ultrasound echo accurate measurement artery volume and the technology of artery volume compensation and precise measurement of ultrasound echo time delay, precise calculation of positions at arterial walls of large arteries can be performed, and accurate artery diameters or cross sectional area numerical values are calculated. Physical quantity with measuring significance of blood volume in a direct characterization artery is obtained. An infrared light intensity signal in an existing blood volume compensation method is replaced by the physical quantity, and negative effects on a measurement result by environmental light and blood volume of peripheral small arteries and veins can be completely removed. In addition, the noninvasive continuous blood pressure measurement device and the method can be directly used on large arteries of superficial layers and matched with an external pressurization air sac and a servo control pressure tracing device, so that the method can be an artery blood vessel volume compensation method in real significance. Continuous blood pressure wavy noninvasive measurement on main arteries can be achieved, and accuracy of the continuous blood pressure wavy measurement is greatly improved.
Owner:SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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