44 results about "Intracranial Artery" patented technology

A whole-body mathematical model (10) for simulating intracranial pressure dynamics. In one embodiment, model (10) includes 17 interacting compartments, of which nine lie entirely outside of intracranial vault (14). Compartments (F) and (T) are defined to distinguish ventricular from extraventricular CSF. The vasculature of the intracranial system within cranial vault (14) is also subdivided into five compartments (A, C, P, V, and S, respectively) representing the intracranial arteries, capillaries, choroid plexus, veins, and venous sinus. The body's extracranial systemic vasculature is divided into six compartments (I, J, O, Z, D, and X, respectively) representing the arteries, capillaries, and veins of the central body and the lower body. Compartments (G) and (B) include tissue and the associated interstitial fluid in the intracranial and lower regions. Compartment (Y) is a composite involving the tissues, organs, and pulmonary circulation of the central body and compartment (M) represents the external environment.

An anchoring delivery system for use in an intracranial artery is provided including a tethering device having an elongated tether and an anchor coupled to a distal end of the tether. The anchor is deployable from a low profile configuration to a higher profile configuration to fix the distal end of the tether at an anchoring site in an anchoring vessel. The tethering device is configured to be used with a guide-sheath having a lumen configured to receive the tether. Related devices, systems, and methods are also described.

An anchoring delivery system for use in an intracranial artery is provided including a tethering device having an elongated tether and an anchor coupled to a distal end of the tether. The anchor is deployable from a low profile configuration to a higher profile configuration to fix the distal end of the tether at an anchoring site in an anchoring vessel. The tethering device is configured to be used with a guide-sheath having a lumen configured to receive the tether. Related devices, systems, and methods are also described.

A device and method for treatment of intracranial vasospasm is provided. The device is a microcatheter having a steeply tapered end and is thicker walled, and in a preferred embodiment is braided to provide greater pushability. In order to achieve a thicker walled catheter, in one embodiment, the inner lumen diameter can be reduced, leaving the outer diameter the same while in another embodiment the catheter is larger in outer diameter. In one embodiment, the microcatheter is coated with performance enhancing lubricant, such as a hydrophilic coating. Further, the microcatheter can also be coated with drugs and serve as a drug delivery device, drugs being embedded into vessel intima. In the use of the method of treatment, the device is fed into the smaller arterial vessels in the brain simultaneously dilating arteries of various caliber along the path of the catheter to relieve vasospasm; pharmacological agents can then be delivered by the microcatheter to further effect treatment.

The present invention provides a stent for intracranial vascular therapy which can be safely held in the intracranial arteries, induces no biological reaction in the blood vessels due to galvanic corrosion or the like, and has elevated visibility under X-ray radioscopy. A stent of the present invention includes a plurality of main struts and a plurality of link struts as its constituents, wherein the stent is made of a single material having higher radiopacity than that of stainless steel, and the main struts and the link struts each have a width ranging from 100 μm to 200 μm and a thickness ranging from 50 μm to 100 μm.

The invention relates to a stent model matching method and device for intracranial aneurysm and a stent simulation display method. The stent model matching method comprises the following steps of: acquiring image data related to intracranial artery blood vessels, and constructing a three-dimensional blood vessel model by processing the image data; obtaining a target area in the three-dimensional blood vessel model, and extracting a blood vessel center line in the target area and a plurality of pieces of center line data of points on the blood vessel center line; carrying out processing according to the blood vessel center line and the center line data to obtain a nominal diameter and a nominal length of the stent; and according to the nominal diameter and the nominal length of the stent, obtaining a matched stent model in a preset stent database. By adopting the method, the stent model matching efficiency and the blood vessel suitability can be improved.

The embodiment of the invention discloses an intracranial vascular image interception method and system based on a central line. The scheme comprises the steps of segmenting a three-dimensional intracranial artery blood vessel image from a received three-dimensional CTA image; Extracting a skeleton line of the target blood vessel segment from the intracranial blood vessel image to be intercepted,and selecting a starting point and a terminal point of the target blood vessel segment; Calculating the shortest path of the starting point and the ending point of the target blood vessel segment based on the skeleton line of the target blood vessel segment, and determining the center line and the radius of the target blood vessel segment; And based on the center line and the radius of the targetblood vessel segment, intercepting the target blood vessel segment of the intracranial blood vessel image. According to the scheme, the blood vessel segment image in the three-dimensional CTA image islocally captured, so that the intracranial artery blood vessel segment can be materialized, and interventional operation simulation and related teaching appliance manufacturing are facilitated.

A helmet manufactured for one specific person, made from rigid synthetic materials, to specifications determined by data obtained from a previously obtained MRI (magnetic resonance imaging) scan of that person's brain, intracranial arteries, and skull. The helmet and its attached adapters hold in place various Doppler probes directed at specific arteries, both intra-cranial and extra-cranial, to provide continuous readings of the velocity of the blood flow through those arteries.

An endovascular bare stent belongs to the technical field of biomedical engineering. The stent is a tubelike mesh-screen stent 1 which is arranged in the blood vessels along the vessel wall. The invention is characterized in that the cross-section of the mesh-screen of the mesh stent 1 takes the shape of a trapezium. The long edge of the trapezium is the outer side 3 of the mesh-screen stent. The short edge of the trapezium is the inner side 2 of the mesh-screen stent. The ratio of short side of the trapezium to long side of the trapezium is less than 50 percent. The penetrating ratio of the mesh-screen of the mesh-screen stent 1 is 40 percent to 80 percent. After the stent covers the aneurysm, the resistance of the blood flowing into the tumor cavity is large, and the resistance of the blood flowing out of the tumor cavity is small; therefore, the blood flowing in the tumor cavity is inhibited so as to reach the purpose of treatment. The stent has little effect on perforating branches vessel, can easily be sent to tortuous intracranial artery, thereby causing the nerves involved in the treatment of cerebral aneurysms more extensive, saving more patients, and being good Gospel for doctors and patients.

The invention provides an intracranial aneurysm virtual stent diagnosis and treatment system and a method thereof. The system comprises a preoperative vascular model and virtual stent initialization model acquisition module which is used for three-dimensional vascular model reconstruction and model smoothing, automatic centerline extraction, and stent model initialization, a virtual stent algorithm execution module which is used for simplex mesh conversion of a virtual stent and preoperative vascular model, virtual stent deployment, vascular wall contact detection and force balance determination, and a surgical plan evaluation module which uses morphological parameters and hemodynamic function parameters to evaluate the effectiveness of a surgical plan developed by a doctor before a surgery. According to the invention, a virtual stent technology based on Simplex mesh is used to simulate the deployment and placement of a stent in an intracranial artery, which ensures the deployment speed of the virtual stent on the basis of ensuring accuracy; the intracranial aneurysm virtual stent diagnosis and treatment system with timeliness and accuracy is built; and guidance is provided for thepreoperative plan planning of intracranial aneurysms.

Embodiments of the present application disclose a method and system for intracranial artery vascular image segmentation. The scheme includes receiving three-dimensional CTA images; based on three-dimensional CTA images, seed points are selected and the gray scale range is determined. Three-dimensional CTA image is binarized to obtain binary image, and the binary image of intracranial artery regionis enhanced by vascular enhancement filter to obtain enhanced image. If there are seed points in three-dimensional CTA images, three-dimensional intracranial arterial images are segmented by region growing method based on enhancement images. If there are no seed points in the three-dimensional CTA image, the three-dimensional intracranial artery image is segmented by interval binary segmentationbased on the enhancement image. This scheme makes the edge of the segmented 3D intracranial artery image clear and saves the filtering time, thus realizing the accurate segmentation of the 3D CTA image of intracranial artery.

The invention relates to an intracranial drug eluting stent system and a preparation method thereof, in particular to an intracranial drug eluting stent used for treating the intracranial atherosclerotic stenosis disease .The intracranial drug eluting stent is composed of a metal stent body and a coating structure covering the surface of the metal stent body, the coating structure comprises one or more stent substrate coatings and drug coatings, and the drug coatings contain a biodegradable drug carrier and a drug inhibiting excessive proliferation of VSMCs .According to the intracranial drug eluting stent, the diseased artery is expanded with the stent to improve intracranial artery blood perfusion, the drug carried by the stent can prevent excessive proliferation of endangium, and thus the probability of in-stent restenosis is lowered; meanwhile, stent healing in the artery can be rapidly achieved, and thus long-term safety and effectiveness are ensured for patients.

Embodiments of the present application disclose a method and system for intercepting intracranial vascular images based on a centerline. The scheme includes selecting the starting point and the endingpoint of the target vessel segment from the intracranial vessel image to be intercepted; calculating a spherical center of the largest inward ball in the target blood vessel segment according to thestart point and the end point of the target blood vessel segment, connecting the start point and the end point, the spherical center determining a centerline and a radius of the target blood vessel segment; intercepting the target vessel segment of the intracranial vessel image based on the centerline and radius of the target vessel segment. This scheme realizes the local interception of the intracranial vascular image, which is convenient for the physicalization of intracranial artery, the simulation of interventional operation and the manufacture of related teaching equipment.

The invention relates to an intracranial aneurysm neck reconstruction device. The intracranial aneurysm neck reconstruction device comprises a reconstruction device body, a guide wire and an outer sheath tube, wherein the reconstruction device body gradually and outwards expands from the near end to the far end; the far end of the reconstruction device body is provided with a head end developing block; the middle end of the reconstruction device body is provided with a middle end developing block; the near end of the reconstruction device body is folded downwards and is fixedly arranged on the guide wire; the guide wire is positioned in the outer sheath tube; a disconnecting point is arranged at the connected position of the guide wire and the reconstruction device body; the other end of the guide wire is connected with a disconnector. The intracranial aneurysm neck reconstruction device disclosed by the invention has the advantages that by implanting the reconstruction device body, the flowing speed of blood in an intracranial aneurysm is slowed down, the hemodynamics in the intracranial aneurysm is changed, and thus the impact from local blood flowing to an aneurismal wall can be reduced; meanwhile, through the implantation of a parent artery reconstruction device body, a local parent artery can be strengthened and repaired, and the physiological structure of a normal part of the parent artery is enabled to recover.

The invention discloses an intracranial aneurysm detection method based on MRA, and the method comprises the following steps: obtaining to-be-processed original image data, carrying out the correction and normalization processing of the original image data, and obtaining the processed image data; performing mIP reconstruction on the processed image data to obtain MIP images, and generating three kinds of rotating images after the external carotid artery is deleted, wherein each rotating image is composed of projections evenly distributed around a single rotating shaft; automatically segmenting intracranial artery blood vessel voxels; manufacturing a plurality of patches for each voxel in the blood vessel area, calculating the probability that all patches contain the aneurysm, classifying the calculated probabilities according to a preset probability threshold value, wherein the voxels larger than the preset probability threshold value generate a volume shape index image and a curvature image based on a curvature algorithm to display the aneurysm; measuring the maximum diameter of the aneurysm; and outputting an aneurysm detection result. According to the method, the intracranial artery blood vessel can be accurately identified, and the size of the aneurysm can be accurately measured.

The invention relates to an intracranial artery segmentation method and system. The method comprises the following steps: acquiring a three-dimensional time leap magnetic resonance blood vessel image to be segmented; inputting the to-be-segmented three-dimensional time leap magnetic resonance blood vessel image into an intracranial artery segmentation model to obtain an intracranial artery image in the to-be-segmented three-dimensional time leap magnetic resonance blood vessel image; obtaining the intracranial artery segmentation model by training a three-dimensional convolutional neural network model, and the three-dimensional convolutional neural network model comprises a first convolutional block module and a second convolutional block module which are connected in sequence; the first convolution block module comprises a plurality of cavity convolution blocks which are connected in sequence, the second convolution block module comprises a plurality of three-dimensional convolution block units which are connected in sequence, and each three-dimensional convolution block unit comprises a three-dimensional convolution block and a three-dimensional voxel rendering neural network module which are connected in sequence. According to the invention, the accuracy of intracranial artery segmentation can be improved.

A device and method for treatment of intracranial vasospasm is provided. The device is a microcatheter having a steeply tapered end and is thicker walled, and in a preferred embodiment is braided to provide greater pushability. In order to achieve a thicker walled catheter, in one embodiment, the inner lumen diameter can be reduced, leaving the outer diameter the same while in another embodiment the catheter is larger in outer diameter. In one embodiment, the microcatheter is coated with performance enhancing lubricant, such as a hydrophilic coating. Further, the microcatheter can also be coated with drugs and serve as a drug delivery device, drugs being embedded into vessel intima. In the use of the method of treatment, the device is fed into the smaller arterial vessels in the brain simultaneously dilating arteries of various caliber along the path of the catheter to relieve vasospasm; pharmacological agents can then be delivered by the microcatheter to further effect treatment.

The invention discloses a head and neck artery stiffness detecting system which comprises a measuring system, a photoelectric sensor, a signal processing device and a signal display device. The head and neck artery stiffness detecting system has the advantages that photoelectric pulse signals of intracranial arteries and extracranial arteries positioned in the heads and the necks of subjects can be acquired by the photoelectric pulse wave sensor for the first time, a novel idea is provided for the head and neck artery stiffness detecting system which is easy to operate and can make the subjects to feel comfortable, a plurality of different locations (such as the necks, the temple windows, the foreheads and the nose wings) which lead into the skulls of the subjects along the carotid arteries in an ascending manner can be detected by the aid of photoelectric plethysmograms, pulse wave oscillograms of the different segmental arteries can be synchronously recorded in the same cardiac cycle, accordingly, functional statuses of the intracranial arteries and the extracranial arteries can be accurately evaluated, and reliable reference foundations can be provided for warning, early screening and diagnosis for ischemic cerebrovascular diseases such as cerebral apoplexy.

The invention provides a construction method of a mouse ischemic stroke model. According to the construction method, current stimulation is given to a Common carotid artery (CCA) of a mouse to form a thrombus embolus, the thrombus embolus is activated, the thrombus embolus is made to spontaneously enter the cranium through an Internal carotid artery (ICA), the intracranial Middle artery (MCA) is blocked, and then acute brain blood supply blocking and brain dysfunction are caused. The invention also provides an evaluation method of the mouse ischemic stroke model. The evaluation method comprises the following steps: marking the thrombus embolus formed on the CCA by using a near-infrared fluorescent molecular probe, tracking the position of the thrombus embolus in the mouse cranium by using a small animal living imaging instrument, and evaluating the ICA clogging degree by using fluorescence intensity.

The invention relates to a stent expansion simulation display method and device after blood vessel implantation, computer equipment and a storage medium. The method comprises the following steps: acquiring image data related to intracranial artery blood vessels, and constructing a three-dimensional blood vessel model by processing the image data; obtaining a target area in the three-dimensional blood vessel model, and extracting a blood vessel center line in the target area and a plurality of center line data of each point on the blood vessel center line; acquiring the model of the implanted stent, and acquiring stent parameters of the implanted stent from a stent database according to the model; and calculating according to the central line of the blood vessel, the data of each central line and the stent parameters to obtain the length of the implanted stent after being unfolded in the blood vessel and displaying the length. By adopting the method, the efficiency of calculating the length of the stent after being unfolded at each position in the blood vessel can be improved, and the unfolding form of the specified stent in the blood vessel can be quickly simulated and displayed.

The invention relates to a balloon catheter conveying device for intracranial angioplasty. The device comprises a conveying catheter, and the conveying catheter is provided with a conveying catheter inner cavity used for enabling a corresponding guide wire and a stent to pass through; an inflatable balloon is arranged at the far end of the conveying catheter, and a guide pipe with the length of 8-20 mm is arranged at the end, away from the conveying catheter, of the inflatable balloon; the guide pipe is a plastic guide pipe or a pre-plastic guide pipe with a bent section, and the guide pipe isprovided with a guide pipe inner cavity which is communicated with the conveying catheter inner cavity and allows the guide wire and the stent to pass through. The balloon catheter conveying device which is used for intracranial angioplasty and capable of precisely guiding the balloon and the stent to a lesion position is provided.

An interventional catheter for treating an artery includes an elongated body sized and shaped to be transcervically introduced into a common carotid artery at an access location in the neck. The elongated body has an overall length such that the distal most section can be positioned in an intracranial artery and at least a portion of the proximal most section is positioned in the common carotid artery during use.

An endovascular bare stent belongs to the technical field of biomedical engineering. The stent is a tubelike mesh-screen stent 1 which is arranged in the blood vessels along the vessel wall. The invention is characterized in that the cross-section of the mesh-screen of the mesh stent 1 takes the shape of a trapezium. The long edge of the trapezium is the outer side 3 of the mesh-screen stent. Theshort edge of the trapezium is the inner side 2 of the mesh-screen stent. The ratio of short side of the trapezium to long side of the trapezium is less than 50 percent. The penetrating ratio of the mesh-screen of the mesh-screen stent 1 is 40 percent to 80 percent. After the stent covers the aneurysm, the resistance of the blood flowing into the tumor cavity is large, and the resistance of the blood flowing out of the tumor cavity is small; therefore, the blood flowing in the tumor cavity is inhibited so as to reach the purpose of treatment. The stent has little effect on perforating branchesvessel, can easily be sent to tortuous intracranial artery, thereby causing the nerves involved in the treatment of cerebral aneurysms more extensive, saving more patients, and being good Gospel fordoctors and patients.

A system for detecting / quantifying the conductance of a right-to-left cardiac shunt includes a mouthpiece assembly, a solenoid-driven vacuum / pressurization assembly; a controller for operating the solenoid-driven vacuum / pressurization assembly; and a monitor for displaying the instructions from the controller. A microbubble counting cell and digital image sensor are combined with software-based image analysis to determine a number of microbubbles contained in a microbubble counting zone. A monitor enables operator specification of total volume of contrast agent to be injected into the patient. One or more first Doppler ultrasound transducer arrays are positioned adjacent to targeted intracranial arteries at one side of the skull or a pair of first Doppler ultrasound transducer arrays positioned adjacent to targeted intracranial arteries at both sides of the skull. A second Doppler ultrasound transducer is positioned on the precordium of the patient to detect the arrival of microbubble-containing contrast agent in the right atrium of the patient.

The invention discloses an intracranial artery plaque recovery cutting stent, and relates to the technical field of medical instruments. The intracranial artery plaque recovery cutting stent comprisesa stent body, an adjusting pull tube, an adjusting pull wire, an expanding and supporting assembly and a plaque cutting assembly, wherein the stent body is internally provided with an adjusting cavity; the front end of the stent body is provided with a mounting step; the adjusting cavity is internally provided with a driving assembly; a connector is arranged at the front end of the adjusting pullwire; the plaque cutting assembly comprises a cutting net, an expanding and supporting air bag and two expanding and supporting nets; two ends of the cutting net are fixedly connected with the adjusting pull tube and a connecting block respectively; the other ends of the two expanding and supporting nets are fixedly connected with the adjusting pull wire; the expanding and supporting air bag is annular and is mounted in the middle of the adjusting pull wire; and the expanding and supporting air bag is located between the two expanding and supporting nets. Radial cutting force of the cutting net on thrombus plaques is guaranteed and control is facilitated, so that the thrombus plaque cleaning effect is improved; and the stent body can be effectively fixed through the expanding and supporting assembly, so that secondary injury to a patient is avoided.

The invention discloses a stent with longitudinal variable width struts. Stents generally can include multiple longitudinal elements each extending over a majority of the length of the stent and eachhaving alternating flexible and rigid segments. The stents can include nodes positioned between the flexible and rigid segments on the longitudinal elements and interconnecting members extending circumferentially to connect adjacent longitudinal elements at the nodes. The longitudinal elements can have a wave pattern and the interconnecting members can have a branch structure connecting peaks fromone longitudinal element to troughs of an adjacent longitudinal element. The resulting stent structure can have lateral and longitudinal flexibility needed to navigate and conform to intracranial arteries with the benefits of recapturability and structural integrity of a closed cell design.

An expandable stent (1) to enhance the supply of blood to downstream tissue which is being supplied with blood through a diseased intracranial artery (100) with a stenosis (102) formed therein by plaque with a bore (103) therethrough. The expandable stent (1) comprises first and second end portions (3,4) joined by a central portion (5). The central portion (5) is configured in the expanded state of the stent (1) to be 10 located in the bore (103) of the stenosis (102) with the first and second end portions (3,4) abutting non- diseased parts (104,106) of the artery (100) adjacent the proximal and distal ends (105,107) of the stenosis (102) for anchoring the stent (1) in the artery (100). The central portion (5) with the stent (1) in the expanded state is configured to apply a radial outwardpressure to the stenosis (102) such that the diameter of the bore (103) of the stenosis (102) is maintained at its current diameter or increased to 15 approximately 50% of the non-diseased parts (104,106) of the artery (100).

The embodiment of the present application discloses a method and system for segmenting an intracranial artery image. The scheme includes: selecting seed points and determining the gray scale range in the three-dimensional DSA image; based on the selected seed points and determining the gray scale range, segmenting the intracranial artery image by using the region growing method. This scheme provides a segmentation method of intracranial arterial blood vessel image with less interference of segmentation noise and higher efficiency of segmentation operation.