The invention relates to a method for establishing a rat
external carotid artery catheter-indwelled cerebral
ischemia reperfusion model. The method includes the following steps that: the direction of an
external carotid artery blood vessel of a rat is drifted, the direction of the
external carotid artery blood vessel of the rat is drifted to a position which is consistent with or parallel to the direction of an
internal carotid artery blood vessel of the rat; the external carotid
artery blood vessel is
cut, a suture is inserted into an incision, so that cerebral
ischemia can be formed in the neck of the rat; and 1 to 2 hours after the suture is inserted into the incision, and cerebral
ischemia is formed, the suture is pulled out, and a
catheter injection bag through which
medicine can be injected repeatedly is arranged into the external carotid
artery blood vessel. According to the method, an external carotid
artery suture method is adopted to manufacture the rat ischemia reperfusion model, and therefore, the normal structures of an operation-side
common carotid artery and an
internal carotid artery can be protected; the
catheter injection bag through which
medicine can be injected repeatedly is indwelled in the external carotid artery,
medicine can be injected into the
internal carotid artery through the artery catheter repeatedly at different time points; nerve functional assessment after the model is established can be realized, and qualified animals could be accepted and subjected to experimental intervention, and therefore, the scientific nature of experiments can be greatly improved.