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Use of stilbene glycoside in treating dementia

A technology of stilbene glycosides and dementia, which is applied in the field of preparation of drugs for the treatment of dementia, and can solve problems such as unsatisfactory effects

Inactive Publication Date: 2002-05-08
XUANWU HOSPITAL OF CAPITAL UNIV OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The former is mainly treated with cholinergic drugs or cholinesterase inhibitors, while the latter’s treatment principles are to improve cerebral vascular circulation and apply brain protective agents, etc., but the effect is often not satisfactory

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Example 1 Stilbene Glycoside (TSG) Protects Nerve Cells Against β-Amyloid-Induced Cell Damage

[0010] 1. Purpose of the experiment

[0011] The characteristic pathological change of senile dementia (Alzheimer disease, AD) is the appearance of senile plaques in the brain, and the deposition of β-amyloid protein (Aβ) constitutes the core of senile plaques. Recent studies have shown that Aβ is toxic to nerve cells, which may be mediated by increased free radicals and calcium ion overload. The purpose of this experiment is to observe the preventive effect of TSG on nerve cell injury caused by Aβ.

[0012] 2. Experimental method

[0013] The human neuroblastoma SK-N-SH cell line (similar to neurons in shape and function) was used for subculture. TSG was pre-incubated with nerve cells for 12 hours or 24 hours, the medium was changed, and β-amyloid (Aβ) active fragments were added for 25-35 hours to incubate the cells with the cells for 6 hours. The supernatant was taken ...

Embodiment 2

[0035] Example 2 TSG protects nerve cells against hydrogen peroxide-induced cell damage

[0036] 1. Purpose of the experiment

[0037] In the pathogenesis of senile dementia and vascular dementia, free radicals and reactive oxygen species play a considerable role in promoting. Aβ first causes free radicals and active oxygen to increase, and then free radicals and active oxygen attack nerve cells, resulting in cell death. Cerebral ischemia can also cause free radicals and reactive oxygen species to increase, resulting in a series of lesions. Long-term damage may affect cognitive function in animal experiments and clinically, and develop into dementia. The purpose of this experiment is to observe the effect of stilbene glucoside (TSG) on active oxygen hydrogen peroxide (H 2 o 2 ) inducing nerve cell damage.

[0038] 2. Experimental method

[0039] The human neuroblastoma SK-N-SH cell line (similar to neurons in shape and function) was used for subculture. TSG was pre-incub...

Embodiment 3

[0062] Example 3 TSG improves the learning and memory function of scopolamine-induced dementia mouse model

[0063] 1. Purpose of the experiment

[0064] In senile dementia, the loss of cholinergic neurons in the basal forebrain is the most serious, resulting in insufficient secretion of acetylcholine. Scopolamine is an M choline receptor blocker, which can block the stimulatory effect of acetylcholine on M receptors, so it mimics the result of insufficient secretion of acetylcholine, and is one of the animal models of senile dementia.

[0065] 2. Experimental method

[0066] (1) Morris water maze experiment: the mice were fed with different doses of TSG for 7 days and then modeled. One hour after administration on the day of the experiment, 1 mg / kg of scopolamine hydrobromide injection was intraperitoneally injected, and the control group was injected with the same amount of normal saline. After 15 minutes, the Morris water maze test was performed twice a day for three con...

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Abstract

The present invention relates to stilbene glycosie compound and the use of its derivative and medicinal salt in preparing medicine for dementia, especially for Alzheimer disease and vascular dementia. Animal experiment proves that stilbene glycoside compound can resist brain cell damage caused by beta-amyloid protein and hydrogen peroxide, raise the memory capacity of mouse model with scopolaminedementia and A beta dementia and gerbille model with double-sided common carotid artery obstruction caused brain ischemia, inhibit the lipide peroxidation of brain tissue of mouse model with brain ischemia, strengthen the activity of its brain tissue SOD, and reduce the calcium ion density in its brain cells.

Description

technical field [0001] The present invention relates to the use of stilbene glycoside compound, its derivatives and pharmaceutically acceptable salts, specifically the use in the preparation of medicines for treating dementia. Background technique [0002] Dementia (dementia) is an acquired and persistent intellectual disability syndrome caused by brain dysfunction. Intellectual impairment includes varying degrees of memory, language, visual space function, abnormal personality and cognitive decline. Dementia mainly includes Alzheimer's disease, Vascular dementia, etc. The pathological changes of Alzheimer's disease include the formation of senile plaques (mainly composed of Aβ (β-amyloid protein), the loss of cholinergic neurons, and the deposition of Aβ in vascular endothelial cells. Vascular dementia is caused by cerebrovascular disease, mainly ischemia. The pathological changes are multiple lacunar lesions or large infarcts and atherosclerotic lesions (see Neurology, F...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7034A61P25/28
Inventor 李林
Owner XUANWU HOSPITAL OF CAPITAL UNIV OF MEDICAL SCI
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