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Compound medicine for treating various diseases related to heart blood supply

A technology of heart and blood supply, applied in the field of medicine, can solve the problems of short dose distance in clinical treatment, achieve the effects of reducing myocardial infarction size, controlling high blood pressure and pulmonary hypertension, and increasing blood supply

Active Publication Date: 2007-04-04
GRAND LIFE SCI (LIAONING) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Both adenosine and nitrates have strong vasodilator effects. Adenosine has a stronger vasodilator effect on small and medium arteries and capillaries, and nitrate drugs have a stronger vasodilator effect on veins and large blood vessels. The clinical application of adenosine The problem is that the dose of clinical treatment and the dose of adverse reactions are relatively close, and the problem faced by nitrate drugs is "nitroglycerin tolerance"

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1 pharmacological experiment

[0030] (1) Materials and methods: healthy Kunming mice, weighing 21-23 g. Randomly divided into adenosine, nitroglycerin, compound adenosine nitroglycerin and normal saline control group.

[0031] Rubidium Chloride 86 (Rb 86 Cl) The half-life is 18.9 days, the radioactivity is 5.5mci / ml, and it is diluted with normal saline when measuring.

[0032]The amount of liquid injected into the abdominal cavity of the experimental animals was 1.0 ml, and the amount of liquid injected into the tail vein was 0.2 ml. The experimental drugs were administered per kilogram of body weight of the mice, respectively: adenosine group 20mg / kg, nitroglycerin group 2mg / kg, compound adenosine nitroglycerin A group adenosine 10mg / kg+nitroglycerin 1mg / kg, compound adenosine nitroglycerin Group B adenosine 20 mg / kg + nitroglycerin 2 mg / kg, compound adenosine nitroglycerin group C adenosine 50 mg / kg + nitroglycerin 5 mg / kg, compound adenosine nitrogly...

example 2

[0037] Example 2: Compound Adenosine Nitroglycerin Injection

[0038] Each bottle of compound adenosine nitroglycerin injection contains adenosine 50mg; nitroglycerin 0.5mg. Dissolve the prescribed amount of adenosine and nitroglycerin in propylene glycol according to the ratio of 100:1, then add the prepared amount of water for injection, stir evenly, absorb with 0.1% (w / v) activated carbon for 15 minutes, filter and decarbonize; % sodium hydroxide to adjust the pH to 7.0-7.5, add water for injection to the full amount, after passing the inspection of the intermediate product, pass through a 0.22 μm filter, fill and seal in a 30ml vial, sterilize at 105°C for 30 minutes, and pack after passing the light inspection . Each bottle contains adenosine 50mg; nitroglycerin 0.5mg.

Embodiment 3

[0039] Embodiment 3: compound adenosine nitroglycerin sodium chloride injection

[0040] Each bottle of compound adenosine nitroglycerin and sodium chloride injection contains 200 mg of adenosine and 3 mg of nitroglycerin. Preparation method: Take adenosine and add it to 50°C water for injection containing citric acid and sodium chloride, blow nitrogen gas, stir slowly while adding until completely dissolved, and obtain solution A. Take another ethanol, add the prescribed amount of nitroglycerin, stir well until it dissolves evenly, and obtain solution B. Slowly add the above-mentioned solution B into the solution A, stir slowly while adding, then add the remaining water for injection, continue stirring for 90 minutes after the addition, and keep flowing nitrogen into the solution during the whole process. Measure the pH value of the intermediate, and adjust the pH value with 1mol / L sodium hydroxide to control it at about 4.0. Filter with 0.45 μm and 0.22 μm microporous memb...

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PUM

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Abstract

A kind of compound medicines for treating the diseases associated with blood supply of heart is a composition of adenosine and nitrate chosen from glycerin nitrate, isosorbitol nitrate and 5-isosorbitol mononitrate.

Description

Technical field: [0001] The present invention relates to the technical field of medicine, specifically the composition, preparation method and preparation method of a compound preparation containing adenosine and nitrate drugs (nitroglycerin, isosorbide dinitrate, 5-isosorbide mononitrate, etc.) indications. Background technique: [0002] At present, cardiovascular system disease is the most common type of disease in human beings, and has become the number one cause of death of the world's population. In my country, with the acceleration of population aging, the improvement of people's living standards, the accelerated pace of life, and the development of eating habits towards high fever and hyperlipidemia, cardiovascular system diseases such as hypertension, hyperlipidemia, and heart failure have become threats to human health and life. one of the serious diseases. Among them, coronary heart disease is a global health problem and a catastrophic disease for human beings tod...

Claims

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Application Information

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IPC IPC(8): A61K31/7076A61K31/34A61K31/047A61P9/10A61P9/12A61P9/04A61P9/00
Inventor 薛百忠杜文斌王宏英
Owner GRAND LIFE SCI (LIAONING) CO LTD
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