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Application of glycyrrhetinic acid in preparing drug for treating pulmonary arterial hypertension

A technology for pulmonary arterial hypertension and glycyrrhetic acid, which is applied in the directions of drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2018-11-02
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether glycyrrhetinic acid has a protective effect on pulmonary hypertension has not been reported

Method used

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  • Application of glycyrrhetinic acid in preparing drug for treating pulmonary arterial hypertension
  • Application of glycyrrhetinic acid in preparing drug for treating pulmonary arterial hypertension
  • Application of glycyrrhetinic acid in preparing drug for treating pulmonary arterial hypertension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The purposes of glycyrrhetinic acid in the preparation treatment pulmonary arterial hypertension medicine, the structural formula of glycyrrhetinic acid is as shown in formula (1):

[0032]

[0033] Among them, the single application dose of glycyrrhetinic acid is limited to the dose that does not cause central nervous system depression, the single application dose of glycyrrhetinic acid is 50 mg / kg for rats, and the dosage form of the drug is a solution dosage form.

Embodiment 2

[0035] The purposes of glycyrrhetinic acid in the preparation treatment pulmonary arterial hypertension medicine, the structural formula of glycyrrhetinic acid is as shown in formula (1):

[0036]

[0037] Among them, the single application dose of glycyrrhetinic acid is limited to the dose that does not cause central nervous system depression, the single application dose of glycyrrhetinic acid is 100 mg / kg for rats, and the dosage form of the drug is injection powder.

Embodiment 3

[0039] The purposes of glycyrrhetinic acid in the preparation treatment pulmonary arterial hypertension medicine, the structural formula of glycyrrhetinic acid is as shown in formula (1):

[0040]

[0041] Among them, the single application dose of glycyrrhetinic acid is limited to the dose that does not cause central nervous system depression, the single application dose of glycyrrhetinic acid is 200 mg / kg for rats, and the dosage form of the drug is injection powder.

[0042] The following animal experiment has further illustrated the effect of above-mentioned embodiment 1 to 3:

[0043] 1. Experimental materials

[0044] 1.1 Animal handling

[0045] Adult male SD rats, 260-300g, were purchased from the Experimental Animal Center of Ningxia Medical University, animal production license number: NCXK (Ning) 2016-0005. Feeding conditions include standard feed, tap water, room temperature maintained at (24±2)°C, humidity 50-60%, and daily light and dark times of 12 hours ea...

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Abstract

The invention discloses application of 18 beta-glycyrrhetinic acid in preparing a drug for treating pulmonary arterial hypertension. An experiment result of the invention shows that when the 18 beta-glycyrrhetinic acid is used in a safe dose range, the 18 beta-glycyrrhetinic acid with the dose of 200mg / kg can remarkably improve the mean pulmonary arterial pressure and the right ventricular systolic pressure of a mouse and lowers the right ventricular and pulmonary small artery remodeling; and the experiment result proves that the 18 beta-glycyrrhetinic acid has the therapeutical effect to thepulmonary arterial hypertension.

Description

technical field [0001] The invention relates to the application of glycyrrhetinic acid, in particular to the application of glycyrrhetinic acid in the preparation of medicines for treating pulmonary hypertension. Background technique [0002] Pulmonary arterial hypertension (PAH) is a group of pulmonary vascular remodeling diseases characterized by continuous increase in pulmonary vascular resistance caused by heterogeneous diseases and different pathogenesis, leading to right ventricular failure and death. rate, high disability rate, and high mortality rate, it is considered a "pseudo-malignant tumor". Vascular smooth muscle cell proliferation, pulmonary vascular remodeling, and pulmonary artery occlusion caused by pulmonary vascular endothelial injury are considered to be the main features of the pathogenesis and pathological changes of pulmonary arterial hypertension. Due to the increase of pulmonary vascular resistance and the increase of right ventricular afterload, ri...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61P9/04A61P11/00A61P9/12
CPCA61K31/56A61P9/04A61P9/12A61P11/00
Inventor 周茹张敏余建强刘宁常智
Owner NINGXIA MEDICAL UNIV
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